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Miklošičeva knjižnica - FPNM, Maribor (PEFMB)
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Miklošičeva knjižnica - FPNM bo od 17. 6. 2024 do 30. 9. 2024 odprta vsak dan od ponedljka do petka od 8.00 do 14.00.

Srečno.
Kolektiv Miklošičeve knjižnice - FPNM
  • What do stimulated beta cells have in common with cancer cells?
    Marhl, Marko
    This study investigates the metabolic parallels between stimulated pancreatic beta cells and cancer cells, focusing on glucose and glutamine metabolism. Addressing the significant public health ... challenges of Type 2 Diabetes (T2D) and cancer, we aim to deepen our understanding of the mechanisms driving insulin secretion and cellular proliferation. Our analysis of anaplerotic cycles and the role of NADPH in biosynthesis elucidates their vital functions in both processes. Additionally, we point out that both cell types share an antioxidative response mediated by the Nrf2 signaling pathway, glutathione synthesis, and UCP2 upregulation. Notably, UCP2 facilitates the transfer of C4 metabolites, enhancing reductive TCA cycle metabolism. Furthermore, we observe that hypoxic responses are transient in beta cells post-stimulation but persistent in cancer cells. By synthesizing these insights, the research may suggest novel therapeutic targets for T2D, highlighting the shared metabolic strategies of stimulated beta cells and cancer cells. This comparative analysis not only illuminates the metabolic complexity of these conditions but also emphasizes the crucial role of metabolic pathways in cell function and survival, offering fresh perspectives for tackling T2D and cancer challenges.
    Vir: Biosystems. - ISSN 0303-2647 (Vol. 242, [article no.] 105257, Aug. 2024, 11 str.)
    Vrsta gradiva - članek, sestavni del
    Leto - 2024
    Jezik - angleški
    COBISS.SI-ID - 200576771

vir: Biosystems. - ISSN 0303-2647 (Vol. 242, [article no.] 105257, Aug. 2024, 11 str.)

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