•A strong home-school collaboration is affecting the quality of inclusive preschool education.•An effective home-preschool collaboration improves learning of children with special ...needs.•Home-preschool collaboration is a dynamic and complex process.•Many challenges still await solutions for a quality collaboration.•Bioecological systems theory can guide the collaborative practice of many professionals.
The aim of the current study was to explore and describe preschool teachers’ experiences regarding home-school collaboration with a focus on children with special needs and their parents in inclusive education. We depended on descriptive phenomenological qualitative research and conducted focus group discussions with 24 preschool teachers. Theoretical thematic analyses have yielded five themes: (1) the components of home-school collaboration, (2) the vital role of parent and teacher involvement, (3) the contributions of collaboration, (4) the challenges from microsystem to macrosystem, and (5) suggestions and solutions. An effective home-school collaboration contributes significantly to the development and learning of children with special needs. However, many challenges still await solutions for a quality collaboration which has complex nature. The bioecological systems theory is a well-known theory that can guide the collaborative practice of many professionals and policy makers.
•Mixed particles performs better than corresponding individual particles in paint.•The most attractive mineral for NaPAA is TiO2 followed by calcite and calcined kaolin•TiO2 and C.Kaolin exhibit the ...maximum yield stress at their iep, calcite shows a minimum at the iep
Different types of minerals in varying amounts are used in paint formulations depending on the paint characteristic. While titanium dioxide (TiO2) is used as a main pigment to improve the paint properties, some minerals such as calcite and calcined kaolin are used as a filler to decrease the cost of the paint, and in some cases as a substitute for TiO2. An important criterion for developing paint formula, especially for architectural ones, is to load maximum amounts of mineral pigments or fillers as much as possible to satisfy the rheology of the paint. Appropriate type and amount of dispersants is crucial at this stage to get the proper flowability at high amount of pigment and fillers.
Polyacrylic acid sodium salt (NaPAA), a well-known dispersant, is generally used as a commercial dispersant in various paint formulations. Interaction of NaPAA with a group of minerals as single or mixture will be rather different. In the case of paint, as a variety of minerals and reagents are available in a mixture, in order to improve the paint formulation, this complex system should be revealed step by step. In the present study, the interaction of single minerals, titanium dioxide (TiO2), calcined kaolin (C.Kaolin), ground calcite (GCC) and their mixtures as TiO2 + GCC, TiO2 + C.Kaolin and TiO2 + GCC + C.Kaolin in the presence of NaPAA was investigated in terms of adsorption, rheology, and electrokinetic phenomena. The results showed that adsorption plateau, zeta potential and viscosity values of the mixtures were very close to the arithmetic mean of the individual minerals of the mixtures. The most attractive mineral ingredient for NaPAA was TiO2, followed by GCC and C.Kaolin. The mixture of minerals behaved differently at the same dosage of NaPAA compared to the single minerals. It is thus important to adjust the minerals mixtures and dispersant type and dosage to closely tune the paint properties. This study clearly revealed that it is more viable to adjust the desired paint properties using a mixture of minerals of different surface properties than a single mineral.
In recent years, biocementation has emerged as a promising technology for soil improvement research. This eco-friendly and sustainable approach involves a range of biochemical treatments, and its ...effectiveness is influenced by various factors. In this study, the effects of soil grain sizes, treatment duration (3, 6, and 11 days) and cementation solution flow rate (0.266, 0.400, and 0.666 ml/sec) on the engineering properties of treated soil were investigated by using the biocementation technique. The strength, calcite percentages, permeability, morphological appearance and structures of the treated sand soils were examined. According to the results, for each soil, different results were obtained with the same flow rates and treatment times. The highest strength value determined as 2406 kPa in the 11 day treatment at 0.400 ml/sec flow rate for smaller particle size of soil whereas the highest strength value obtained as 1504 kPa in the 11 day treatment at 0.266 ml/sec flow rate for larger particle size of soil. Higher strength results were obtained at lower flow rates (0.266 ml/sec) in samples with large grain diameter while strength results could not be obtained from it after treatment at higher flow rates (0.400, 0.666 ml/sec). In addition, strength results were obtained with a smaller grain diameter at a high flow rate (0.666 ml/sec), but decreased from 1599 to 1190 kPa when raising the treatment duration from 3 to 11 days. The flow rate and treatment duration in studies should therefore be chosen according to the particle size distribution of the soil.
Phytochemicals such as curcumin have great potential in cancer prevention and treatment. However, instability and low aqueous solubility of free curcumin weaken its anticancer potential. These ...undesirable problems can be avoided upon loading curcumin into nanoparticles containing biocompatible and biodegradable polymers such as poly lactic-
co
-glycolic acid (PLGA), liposomes or micelles. The interaction of drugs and release control can be further enhanced upon inclusion of clay minerals into the PLGA containing nanoparticles. Such nanoparticles offer a new way for cancer drug delivery systems. However, the role of the clay mineral in the resulting composite is not fully understood. Therefore, in this study, we carried out systematic adsorption studies of curcumin anticancer drug on montmorillonite (MMT) nanoparticles in the presence of amphiphilic polymer (PLGA) and in an aqueous environment to understand the contribution of the layered clay structure using cluster (B97-D), periodic DFT and molecular dynamics (MD) simulations in acidic and natural pH media. It has been found that MMT has high affinity towards either polymer or drug molecules especially due to vdW interactions. Furthermore, it has been observed that MMT facilitates the release of curcumin. Current findings suggest that a composite consisting of MMT and PLGA might be used to deliver the anticancer agent curcumin.
Curcumin as an anticancer agent can be delivered with a composite including poly(lactic-
co
-glycolic acid) and montmorillonite.
New cis - ( 4–6 ) and trans -dispirocyclic ferrocenylphosphazene derivatives ( 7–9 ) were obtained by reactions of hexachlorocyclotriphosphazene (N 3 P 3 Cl 6 ) with N -alkyl- N ...-monoferrocenyldiamines of the formula FcCH 2 NH(CH 2 ) n NHR n = 2, R = CH 3 ( 1 ); n = 2, R = C 2 H 5 ( 2 ) and n = 3, R = CH 3 ( 3 ). Characterizations of the products were performed using MS, FTIR, 1 H, 13 C and 31 P NMR techniques. The crystal structures of 5 (with 8 ), 6 , 7 and 9 were determined by X-ray crystallography. The most important result of this study was that the trans chiral phosphazenes crystallized as only one enantiomer. Studies of the antibacterial and antifungal activity of the phosphazenes ( 4–9 ) showed that compounds 6 and 7 were effective against P. vulgaris and K. pneumoniae . The cytotoxic activities of 4–9 against L929 fibroblasts and DLD-1 colon cancer cells were investigated. The necrotic effects of 4 and 7 were greater in the DLD-1 cell line than those in the L929 cell line. DFT calculations were carried out using the B3LYP functional with the LANL2DZ basis set to determine the energies, the orientations of the molecular orbitals (HOMOs and LUMOs) and the molecular electrostatic potential (MEP) surfaces of the partly substituted cyclotriphosphazenes ( 6 , 7 and 9 ). The results for 6 , 7 and 9 revealed that these bonded to the active sites of A-DNA and B-DNA by weak non-covalent interactions, which was also supported by molecular docking investigations.
•The program could be carried out in a home environment.•The program increased the interactional behaviors of parents and children.•The program decreased the number of difficult routines.•The program ...was considered as “educational, instructive and a band-aid” by parents.•Issues such as developing systematic psycho-social support systems that increase the full participation and motivation of parents in distance education programs during periods such as pandemics, overcoming difficulties in online data collection, using coaching and counseling systems for the maintenance of information, individualizing the program, making it more interactive and preparing applied training programs on different subjects need to be resolved.
During the COVID-19 pandemic, the development of emergency remote training programs for young children with Down syndrome, learning difficulties, and severe health problems and their parents became a requirement. The present study aimed to evaluate the impact of the “applied emergency remote training program”, prepared to address the needs of parents with children with Down syndrome and to offer them at-home support. It is an evaluative case study conducted with 11 parents of 11-35 months old children with Down syndrome. The findings demonstrated that the program could be conducted in a home environment, it improved the interactional behavior of both parents and children, reduced the number of difficult routines, and was considered as an educational, instructive, and band-aid solution. Issues such as the development of systematic psycho-social support systems that increase full participation and motivation of parents in distance education programs are important during extreme times such as the pandemic. Difficulties in online data collection, the employment of coaching and counseling systems in information maintenance, individualization of the program, the improvement of the interactivity in the program, and the development of applied training programs on different topics still wait for a solution.
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► A new, rapid and sensitive on-line HPLC assay for biothiols was proposed. ► Postcolumn derivatization was performed with methyl-β-cyclodextrin-containing DTNB. ► Biothiols were ...selectively determined individually among other antioxidants. ► The oligosaccharide helped to improve the sensitivity.
A novel on-line HPLC-DTNB method was developed for the selective determination of biologically important thiols (biothiols) such as l-cysteine (Cys), glutathione (GSH), homocysteine (HCys), N-acetylcysteine (NAC), and 1,4-dithioerythritol (DTE) in pharmaceuticals and tissue homogenates. The biothiols were separated on C18 column using gradient elution, reacted with the postcolumn reagent, DTNB in 0.5% M-β-CD (w/v) solution at pH 8, to form yellow-colored 5-thio-2-nitrobenzoic acid (TNB), and monitored with a PDA detector (λ=410nm). With the optimized conditions for chromatography and the post-column derivatization, 40nM of NAC, 40nM of Cys, and 50nM of GSH can be determined. The relative standard deviations of the recommended method were in the range of 3.2–5.4% for 50μM biothiols. The negative peaks of biothiol constituents were monitored by measuring the increase in absorbance due to TNB chromophore. The detection limits of biothiols at 410nm (in the range of 0.04–0.58μM) after post-column derivatization with DTNB+M-β-CD were much lower than those at 205nm UV-detection without derivatization, and were distinctly lower than those with post-column DTNB alone. The method is rapid, inexpensive, versatile, nonlaborious, uses stable reagents, and enables the on-line qualitative and quantitative estimation of biothiol constituents of biological fluids and pharmaceuticals.
An isolate of
Streptomyces decoyicus
M* (code of the isolate) was identified by the sequencing of 16S rRNA gene. It was grown on solid media and secondary metabolites were extracted with
n
-butanol. ...The extract was dried and run in a sodium dodecyl sulphate–polyacrylamide gel (SDS–PAGE, 10%). Two main bands obtained were sliced and the metabolites were regained in
n
-butanol. These two samples were then identified by gas-chromatography–mass spectrometry (GC–MS), and Fourier-transform infrared spectroscopy (FT-IR). The results demonstrated that tromethamine- and 1-dodecanol were the main constituents (band 1: 61% and 17.7%; band 2: 41% and 54%, respectively). This finding maintained that the isolate of
Streptomyces decoyicus
produced high amounts tromethamine- and 1-dodecanol under the conditions investigated.
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