The study aimed to make comparison between the resilience, life satisfaction, care burden and social support of mothers with a child with acute lymphoblastic leukaemia (ALL) and those with a healthy ...child. The study was carried out using the comparative and descriptive methods, and the study group included mothers with ALL children hospitalised in the Paediatric Haematology Clinic of a university hospital (n = 51) and those with healthy children who applied to a family health centre (n = 53). While collecting the data, Personal Information Form, Resilience Scale for Adults, Life Satisfaction Scale, Zarit Care Burden Scale and Multidimensional Scale of Perceived Social Support Scale were used. The data were statistically analysed using the SPSS program, percentages, mean scores, standard deviations, Mann–Whitney U test and pearson correlation. For the comparison of the personal information about the mothers with ALL children and about those with healthy children, chi‐square or student t test for independent groups depending on the data set was used. When the mothers with ALL children were compared with those with healthy children, it was found that the methods with ALL children had statistically lower mean scores for life satisfaction (13.92 ± 6.26, p < 0.001) and resilience (17.90 ± 7.09, p < 0.001) and statistically higher mean scores for care burden (42.23 ± 16.54, p < 0.05). In this study, when the mothers of ALL children were compared with those of healthy children, it was found that the former had lower levels of resilience and life satisfaction and higher levels of care burden.
Centipede bites have been reported rarely in humans. The mechanism of centipede toxin is not fully understood. Skin reactions develop more in centipede bites. In this text, we will present a case ...that developed thrombocytopenia after a centipede bite. An 18-month old female infant was bitten on the back of the right hand and the right side of the forehead. She applied to the emergency department with the complaint of redness and swelling that started in the morning hours after the bite. The vital signs of the patient were stable. The patient had no systemic complaints. The patient's laboratory tests, PLT was 28,000 K/UL were determined. During follow-up of the patient, bleeding symptoms developed associated with thrombocytopenia. The follow-up examination 10 days later, thrombocyte count was determined as 302,000 in the full blood count. Centipede bites are not greatly reported and the actual incidence is undoubtedly higher than assumed. Although the majority spontaneously recover with only simple local reactions that have formed, they can lead to serious complications such as acute myocardial infarcts, acute coronary ischemia, acute renal damage, anaphylaxis, or thrombocytopenia. Therefore, following a centipede bite, patients must be evaluated carefully and attention must be paid in respect of complications.
Background:
Thalassemia major (TM) is an inherited anaemia caused by faulty haemoglobin synthesis. Reducing serum iron levels using iron chelating agents is an important step in the treatment of TM, ...and the effects on the eye of both the disease and these agents can be determined by regular eye examination.
Objectives:
We evaluated macular and optic nerve vascular densities in children with TM and compared the results with healthy controls using optical coherence tomography angiography (OCTA).
Design:
This is a prospective study.
Methods:
A total of 30 children with TM and 30 healthy controls were included in the study. The area of the foveal avascular zone (FAZ) and the vascular densities (VD) of the optic nerve head (ONH), radial peripapillary capillary (RPC) and deep and superficial retinal vascular networks were measured using OCTA.
Results:
A statistically significant decrease in VD was observed in the whole image and the parafovea, superior hemi, superior and inferior parts of the superficial capillary plexus and in the whole image and the superior regions of the deep capillary plexus in the TM patient group compared with the control group (p < 0.05). A significant decrease in VD was also observed in the whole image and the inside disc, peripapillary, nasal, inferonasal and temporal regions of the ONH and in the whole image and the inside disc, peripapillary and inferonasal regions of the RPC network in patients with TM (p < 0.05). A significant positive correlation was observed between both serum ferritin levels and deferasirox dosage, on one hand, and both the superficial (p = 0.023 and p = 0.002, respectively) and deep FAZs (p = 0.015 and p = 0.045, respectively), on the other hand. A negative correlation was also found between the deferasirox dosage and the VDs of the superficial (p = 0.010) and deep (p = 0.001) foveal plexuses.
Conclusion:
Retinal VD and FAZ are affected in patients with TM. OCTA, which can noninvasively measure retinal VD in patients with TM, may be a useful tool for the early detection of retinal microvascular changes that may occur during the course of the disease.
Abstract
Objectives
Hemoglobin disorders are quite heterogeneous in the Turkish population. Up to now, more than forty different beta thalassemia mutations and 60 hemoglobin variants have been ...characterized in the country. The aim of this study was to investigate genetic heterogeneity of HBB gene mutations in patients and their parents at Southeastern Anatolia in Turkey.
Methods
Genomic DNA was isolated from 145 thalassemic patients’ blood samples and their parents in this study. Ten different HBB gene mutations HBB:c.-80T>A, HBB:c.17_18delCT, HBB:c.25_26delAA, HBB:c.92+1G>A, HBB:c.92+5G>C, HBB:c.92+6T>C, HBB:c.93-21G>A, HBB:c.135delC, HBB:c.315+1G>A, HBB:c.316-106C>G were screened by amplification refractory mutation system. Four Hb variants and some rare beta thalassemia mutation were characterized by DNA sequencing.
Results
In this study, 97 homozygous and 48 compound heterozygous thalassemic patients were diagnosed by molecular genetic analyses. As a results, 18 β-thalassemia mutations and four abnormal hemoglobins; HBB:c.20A>T, HBB:c.364G>C, HBB:c.34G>A and HBB:c.208G>A were detected at Dicle University Hospital.
Conclusions
In the results, HBB:c.93-21G>A is the most common mutation in the region. Three mutations (HBB:c.93-21G>A), (HBB:c.25_26delAA) and (HBB:c.135delC) account for about 58 per cent of all the point mutations. Except HBB:c.20A>T and HBB:c.364G>C, two silent Hb variants (HBB:c.34G>A and HBB:c.208G>A) were detected in this study. Hb Hamilton β11 (GTT>ATT) Val>Ile was seen first time in Turkey.
Although many pediatric studies on children infected with coronavirus disease 2019 (COVID-19) have been published, the diagnosis, clinical symptoms, laboratory findings, and treatment of COVID-19 in ...children are still unclear.
This study was conducted with an aim to examine the hematological findings of symptomatic pediatric patients diagnosed with COVID-19 in May 2020 at the Pandemic Hospital in Dicle University. Patient records were evaluated retrospectively. This study involved 59 symptomatic pediatric patients with a definite diagnosis of COVID-19 who had positive SARS-CoV-2 RT-PCR test results on nasopharyngeal swab between March 15, 2020 and May 31, 2020.
The records of a total of 10 (16.9%) patients under the age of 1; 21 (35.6%) patients aged 1-10 years, and, 28 (47.5%) patients aged 10-18 years, who had been diagnosed with COVID-19 were evaluated. Based on severity, 35 (59.3%) patients were in the mild group (group 1) and 24 (40.7%) patients were in the moderate-severe group (group 2). The blood parameters of WBC, neutrophil, lymphocyte, monocyte, and thrombocyte counts, the hemoglobin (Hgb) level, and NLR, PLR, MPV, fibrinogen, ferritin, and D-dimer levels were compared between groups, the difference was not statistically significant (P > .05). LDH was higher in group 2 (P = .014).
Since children infected with COVID-19 show mild clinical symptoms or are asymptomatic, fewer pediatric patients may be detected than adults. Therefore, it should be known that the laboratory findings typical for adults may not accompany the disease in pediatric cases. More studies are needed to determine the most appropriate COVID-19 treatment approach for children, as hospitalization history and testing rates are less reported among children.
Cancer was a common noncommunicable disease in Syria before the present conflict and is now a major disease burden among 3.6 million Syrian refugees in Turkey. Data to inform health care practice are ...needed.
To explore sociodemographic characteristics, clinical characteristics, and treatment outcomes of Syrian patients with cancer residing in the southern border provinces of Turkey hosting more than 50% of refugees.
This was a retrospective hospital-based cross-sectional study. The study sample consisted of all adult and children Syrian refugees diagnosed and/or treated for cancer between January 1, 2011, and December 31, 2020, in hematology-oncology departments of 8 university hospitals in the Southern province of Turkey. Data were analyzed from May 1, 2022, to September 30, 2022.
Demographic characteristics (date of birth, sex, and residence), date of first cancer-related symptom, date and place of diagnosis, disease status at first presentation, treatment modalities, date and status at last hospital visit, and date of death. The International Statistical Classification of Diseases and Related Health Problems, Tenth Revision and International Classification of Childhood Cancers, Third Edition, were used for the classification of cancer. The Surveillance, Epidemiology, and End Results system was applied for staging. The diagnostic interval was defined as the number of days from first symptoms until the diagnosis. Treatment abandonment was documented if the patient did not attend the clinic within 4 weeks of a prescribed appointment throughout the treatment.
A total of 1114 Syrian adult and 421 Syrian children with cancer were included. The median age at diagnosis was 48.2 (IQR, 34.2-59.4) years for adults and 5.7 (IQR, 3.1-10.7) years for children. The median diagnostic interval was 66 (IQR, 26.5-114.3) days for adults and 28 (IQR, 14.0-69.0) days for children. Breast cancer (154 13.8%), leukemia and multiple myeloma (147 13.2%), and lymphoma (141 12.7%) were common among adults, and leukemias (180 42.8%), lymphomas (66 15.7%), and central nervous system neoplasms (40 9.5%) were common among children. The median follow-up time was 37.5 (IQR, 32.6-42.3) months for adults and 25.4 (IQR, 20.9-29.9) months for children. The 5-year survival rate was 17.5% in adults and 29.7% in children.
Despite universal health coverage and investment in the health care system, low survival rates were reported in this study for both adults and children with cancer. These findings suggest that cancer care in refugees requires novel planning within national cancer control programs with global cooperation.
Article Note: Rejin Kebudi, Nilgun Kurucu, and Deniz TuAcu have contributed equally. On behalf of the Turkish Pediatric Oncology Group (TPOG) and Turkish Pediatric Hematology Society (TPHD). Byline: ...Rejin Kebudi, Nilgun Kurucu, Deniz TuAcu, Aadan HacA+ or -salihoAlu, Tunc FA+ or -AgA+ or -n, Suheyla Ocak, Gulnur Tokuc, Gul Nihal Ozdemir, Ceyhun Bozkurt, Dilek Adegreesnce, Seda Aras, Ali Aycicek, BaAak AdaklA+ or - Aksoy, Nihal KaradaA, Gulyuz Ozturk, Mehmet Fatih Orhan, Eda Ataseven, Sinan Akbayram, Ebru YA+ or -lmaz, Ozlem Tufekci, Sema Vural, Arzu Akyay, Aylin Canbolat Ayhan, Suar KA+ or -lA+ or -c, Veysiye Hulya Uzel, Yeter Duzenli, Elif Guler KazancA+ or -, Can AcA+ or -payam, Murat Elli, Atilla Tanyeli, Zeynep Karakas, Ayper Somer, AteA Kara
Amaç: Adrenalin oto-enjektörü, anafilaksi tedavisinde ana ilaçtır. Polikliniklerin yoğunluğu ve eğitim süresinin kısalığı nedeniyle ebeveynler yetersiz oto-enjektör eğitimi alabilmektedir. Adrenalin ...oto enjektörü konusunda yüz yüze eğitimden sonra alternatif yöntemlere ihtiyaç duyulmaktadır. Bu nedenle, bir yapboz oyununun annelerin bu açıdan becerilerini geliştirebileceği hipotezini araştırdık.
Gereç ve Yöntemler: Grup 1’de anafilaksili hastaların annelerine sadece yüz yüze eğitim verildi. Grup 2’de katılımcılara yüz yüze eğitimin ardından bir puzzle oyunu verildi. Toplam süre ve puanlama gruplar arasında karşılaştırıldı. Kategorik değişkenler için ki-kare (χ2) testi ve gruplar arası sayısal değişkenleri karşılaştırmak için Mann-Whitney U testi (parametrik olmayan) veya Student t testi (parametrik) kullanıldı.
Bulgular: Çalışmaya toplam 80 katılımcı dahil edildi. Grup 2’de doğru oto-enjektör kullananların oranı (%85), grup 1’den (%67.5) daha yüksekti (p=0.020). Grup 2’de (14±2 saniye) doğru kullanıcılar, adrenalin oto-enjektörünün tüm adımlarını grup 1’den (19±2 saniye) önemli ölçüde daha hızlı gerçekleştirdi (p<0.001).
Sonuç: Bir yapboz oyunu ile adrenalin oto-enjektörleri üzerine eğitim, bakıcı becerilerinin eksikliğini gidermek için görsel ve pratik bir yöntem olarak faydalı olabilir. Rutin adrenalin oto-enjektör eğitiminin bir parçası olarak bir yapboz oyunu kullanılmalıdır.
Objective: Adrenaline auto-injector is the main drug for treating anaphylaxis. Parents may receive insufficient auto-injector training due to the intensiveness of outpatient clinics and shortness of duration of the training period. Therefore, we explored the hypothesis that a puzzle game as an alternative method may improve mothers’ skills in this aspect.
Material and Methods: The mothers of patients with anaphylaxis were given only face-to-face training in group 1. In group 2, a puzzle game was given to participants after the face-to-face training. The chi‐squared (χ2) test was used for categorical variables and the Mann–Whitney U test or Student’s t test were employed to compare the numerical variables between the groups.
Results: A total of 80 participants were included in the study. The rate of correct auto-injector users in group 2 (85%) were higher than group 1 (67.5%) (p=0.020). Correct users in group 2 (14±2 second) performed all steps of adrenaline auto-injector significantly faster than group 1 (19±2 second) (p<0.001).
Conclusion: Training on adrenaline auto injectors with a puzzle game can be useful as a visual and practical method to overcome the lack of caregiver skills. A puzzle game should be used as part of routine adrenaline auto-injector training.
Background
The novel coronavirus disease (Covid‐19) can progress with mild to moderate or self‐limiting clinical findings in children. The aim of this study was to investigate the disease features of ...Covid‐19 in Turkish children.
Methods
Children diagnosed by the method of real‐time reverse transcription‐polymerase chain reaction for Covid‐19 at the Dicle University Department of Pediatric, between April and June 2020, were evaluated. Hospital records were investigated retrospectively.
Results
One hundred and five patients children with the mean age of 108.64 ± 65.61 months were enrolled in this study. The most common cause of transmission in pediatric patients was in contact with a family member diagnosed with COVID‐19 (n = 91, 86.7%). The most common admission complaints were dry cough (n = 17, 16.2%), fever (n = 16, 15.2%), lassitude and fatigue (n = 14, 13.3%) respectively. More than 95% of all children with Covid‐19 were asymptomatic, mild, or moderate cases. CRP was identified only independent factor associated with long duration of hospitalization.
Conclusion
The results of this study show the effect of Covid‐19 on Turkish children. A clear understanding of the local epidemiology of corona virus infections and identification of risk factors are critical for the successful implementation of the prevention and control program.
PDF
