Od svibnja do listopada 2011. godine na području sjevernoistočne Slovenije (Rakičan, 46°65‘21‘‘ s.g.š., 16°19‘13‘‘ v.g.d., 188 m n.v.) izveli smo pokus u kojem smo istraživali značajke tri vrste ...trava i četiri mješavine trava na srednje intenzivno uzgojenom travnjaku poslije dvije godine rasta. Pokus je bio postavljen u rujnu 2009. godine po metodi slučajnog redosljeda pokusnih jedinica u četiri ponavljanja. Veličina osnovne pokusne jedinice bila je 10 m2. Količina sjemena za sjetvu bila je 250 kg na hektar. Pokus smo gnojili s 200 kg N na ha (u 7 prihrana), 60 kg P2O5 na ha i 120 kg K2O na ha. U pokusu smo ocjenjivali i određivali: boju travnjaka, brzinu rasta, prazna mjesta, gustoću trave, zakorovljenost, otpornost na sušu, otpornost na bolesti, utjacaj vremenskih uvjeta i prinos suhe tvari na ha pojedine mješavine. Analiza rezultata pokusa je pokazala da se mješavina trava 3, sastavljena od trstikaste vlasulje(Festuca arundinacea) – sorta ‚Arid 3‘ (50 %) i dvije sorte engleskog ljulja (Lolium perenne L.) – sorte ‚Panderosa‘ (25 %) i sorte ‚Mondial‘ (25 %) značajno isticala, po ocijenjenim parametrima od ostalih vrsta trava i mješavina trava iz pokusa
From May to October 2011, a field experiment was conducted in the north eastern Slovenia (Rakičan, 46°65’21’’ N, 16°19’13’’ E, 188 m s.l.), where we studied the properties of three grasses and four grass mixtures appropriate to create a medium- intensive ornamental lawn after the second year of growth. The experiment was designed in September 2009 as randomized blocks with four repetitions. The size of the basic plot was 10 square metres. For sowing 250 kg of seeds per hectare were used. The treatments were fertilized with 200 kg N ha -1 (in seven fertilizations), 60 kg P2O5 ha -1 and 120 kg K2O ha -1.In the experiment, we assessed and evaluated turf colour, growth rate, bare spots, turf density, weeds, drought resistance, and turf resistance to disease, the impact of weather conditions and dry matter yield of each mixture. The results obtained in the experiment indicated that the grass mixture No. 3, composed of tall fescue (Festuca arundinacea) – cv. ‘Arid 3 (50%) and perennial ryegrass (Lolium perenne L.) – cv. ‘Panderosa’ (25%) and cv. Mondial’ (25%), significantly differed from the remaining grasses and grass mixtures according to the observed parameters.
Coat color of gray horses is associated with a 4.6-kb duplication, which can be determined using PCR amplification of about 5-kb DNA fragment. In practice, this means that amplification might fail ...frequently. Therefore, a novel genetic screening method based on amplification of the 246 bp DNA fragment has been developed.
Background: Chronic myeloid leukemia (CML) is a malignant myeloproliferative disorder of hematopoietic stem cells. It is the first malignancy with a known specific chromosomal abnormality, the ...Philadelphia (Ph) chromosome t(9;22) (q34;q11), which has become a model in the research and treatment of malignant diseases. With the development of targeted drugs, tyrosine kinase inhibitors (TKI) in the 21st century, the strategy of CML treatment has changed completely , and thus also the quality of life and survival. In Slovenia, the use of TKI started in 2002. We show the treatment results in the Slovenian population. Methods: The retrospective analysis included patients with CML treated in all Slovenian hematology centres. We reviewed the period from 2002 to the end of 2011. Patients were divided into three groups: (A) newly diagnosed patients treated between 2002 and 2006, (B) newly diagnosed patients from January 2007 until the end of November 2011, and (C) all patients together. As the guidelines for the treatment of CML werepublished in 2006, we decided for this distribution of patients in order to find out whether our treatment results were any better because of that. Results: From early 2002 until the end of 2011, 164 new patients with CML were detected in Slovenia (group A-74, Group B-92). In group A, 56 (76 %) patients are still alive, 18 (24 %) have died , and 46 (62 %) reached major molecular response. Overall survival of patients after nine years of treatment is 80 %. Out of 12 patients with HSCT, 6 are alive. In group B, 85 patients are alive (91 %), major molecular response was achieved in 49 patients (52 %), 25 have been treated for less than 18 months and the result is not relevant. In this period none of the patients had HSCT. Fouryear survival is 81 %. In the total group of patient (C), major molecular response was achieved in 64 % of patients, in 75 % with imatinib. Because of intolerance or no response to imatinib, 25 % of patients are receiving second-generation tyrosine- kinase inhibitors, dasatinib in 20 % and nilotinib in 80 %. Conclusions: Treatment results of the Slovenian CML patients' population are comparable with those published in the literature. Since this is an entirely retrospective study, many data are lacking, which is disturbing. From this point, it is important to revive the Slovenian registry of CML patients' population.
BACKGROUND Chronic myeloid leukaemia (CML) is a rare clonal neoplastic disease of hematopoieticstem cells. Epidemiology data of CML patients in Slovenia are presented. METHODS Data about all new ...patients with CML in the period from 2002 to 2007 were obtained fromall Slovenian hospitals with haematological department. RESULTS 90 patients were studied during the period of 6 years. The incidence was 0.75/100,000 onaverage. 14 patients (15 %) died. Incidence in male population was 4 % higher as infemale population. The patient population (average age 50.6 in males and 59.1 in femalesat the diagnosis of CML, respectively) was distributed also according to Slovenian statistical regions. The majority of patients was identified in the chronic phase of disease (83 %),being treated in recent years with imatinib (up to 85 % in 2007). CONCLUSIONS The incidence, as well as the average age of the patients with CML in Slovenia is lowercompared with data from the literature. The majority of patients are identified in earlystage of the disease and are treated in accordance with current guidelines
BACKGROUND Chronic myeloid leukaemia (CML) is a rare clonal neoplastic disease of hematopoieticstem cells. Epidemiology data of CML patients in Slovenia are presented. METHODS Data about all new ...patients with CML in the period from 2002 to 2007 were obtained fromall Slovenian hospitals with haematological department. RESULTS 90 patients were studied during the period of 6 years. The incidence was 0.75/100,000 onaverage. 14 patients (15 %) died. Incidence in male population was 4 % higher as infemale population. The patient population (average age 50.6 in males and 59.1 in femalesat the diagnosis of CML, respectively) was distributed also according to Slovenian statistical regions. The majority of patients was identified in the chronic phase of disease (83 %),being treated in recent years with imatinib (up to 85 % in 2007). CONCLUSIONS The incidence, as well as the average age of the patients with CML in Slovenia is lowercompared with data from the literature. The majority of patients are identified in earlystage of the disease and are treated in accordance with current guidelines
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