We present a patient with uncommon metastases of lung cancer. The patient has been followed-up for early stage laryngeal carcinoma in the remission and has had dyspeptic complaints as well. A ...62-year-old male patient had epigastric complaints for three months. In the upper endoscopy, a biopsy specimen taken from the polyp in the second region of the duodenum was reported as squamous cell cancer. Immunohistochemical staining of tumor cells were positive for CK5/6, p40, and p63. A mass in the right lung was detected on thorax tomography. The result of the transthoracic needle biopsy indicated squamous cell cancer. Duodenal metastasis of lung cancer is highly unlikely. Lesions below 1 cm can be safely removed endoscopically. Duodenal metastasis of primary lung cancer can be considered in the differential diagnosis of resistant dyspepsia.
Short-term survival rates are reported in the patients undergoing percutaneous transhepatic biliary drainage (PTBD). The purpose of this study was to determine the factors predicting survival ...following percutaneous biliary drainage.
The data of 90 patients undergoing PTBD due to malignant biliary obstruction were analyzed retrospectively between January 2009 and November 2014.
The median age of the patients were 64 years. Fifty-one (57%) of the patients were male. Median survival following PTBD was 44 days. Survival rates at 1 month, 3 months, and 6 months following PTBD were 58%, 33%, and 8.9%, respectively. Multivariate Cox's regression analysis showed that platelet (PLT) count is significantly associated with predictors of survival; the other factors affecting survival were receiving chemotherapy following PTBD, liver metastasis, and serum albumin levels.
Lower serum PLT level following PTBD is associated with the short-term survival. Survival of patients who are not able to receive chemotherapy after PTBD, having a low level of serum albumin, and patients with liver metastasis were shorter.
Hypocalcemia with stridor is a well-known condition in the pediatric age group but has rarely been reported in the elderly. We report an elderly patient who presented with dyspnea and laryngeal ...stridor attack caused by hypocalcemia. The patient had been suffering from stridor and dyspnea episodes for 2 years, and the etiology had not been determined until the evaluation in our department. The cause of stridor was hypocalcemia secondary to thyroidectomy. Complete resolution of stridor was achieved by calcium replacement therapy.
The role of the systemic inflammatory response in cancer has been shown in many studies. The present study aims to investigate the prognostic significance of a new hematologic index obtained by the ...combination of platelet, neutrophil, and lymphocyte counts in patients undergoing curative gastrectomy for gastric cancer.
We retrospectively analyzed 95 consecutive patients who underwent curative gastrectomy for gastric cancer between January 2013 and December 2018. Receiver operating characteristics curve analysis was used to determine the optimal cutoff values for hematologic inflammatory index (HII). The optimal cutoff value for HII was 2.69. Baseline parameters categorized into two groups were compared with the Chi-square test. Variables were evaluated by the univariate analysis were further assessed by the multivariate analysis using Cox's proportional-hazards regression model.
According to HII, 44 patients (46.3%) had values lower than 2.69 and 51 patients (53.7%) had values higher than 2.69. HII was significantly correlated with depth of tumor invasion (P = 0.009), tumor histologic type (P = 0.048), and need for adjuvant therapy (P = 0.04). Median disease-free survival (DFS) (P = 0.003, hazard ratio (HR), 0.423; 95% confidence interval CI, 0.234-0.762) and median overall survival (OS) (P = 0.002, HR, 0.385; 95% CI, 0.207-0.716) were found to be significantly shorter in the patient group where HII was higher than 2.69 compared to the patient group whose HII was lower than 2.69. When the multivariate analysis was performed, both DFS (P = 0.025, HR, 0.484; 95% CI, 0.257-0.912) and OS (P = 0.04, HR, 0.497; 95% CI, 0.255-0.970) were found to be independent prognostic factors.
In this retrospective study, HII is independently associated with both DFS and OS in gastric cancer. HII is an inexpensive, powerful, and easily accessible prognostic marker.
Aim: In metastatic renal cell carcinoma (RCC), prognosis relies on various factors. Tumor lateralization's role is still debated. Our study examined how tumor localization affects survival in ...metastatic RCC patients.Materials and Methods: The study retrospectively analyzed 80 patients with metastatic renal cell carcinoma, diagnosed between January 1999 and December 2021. Results: Eighty patients were evaluated. The median age at diagnosis was 60 (range 37-86). Tumors were in the right kidney for 39 patients (48.8%) and in the left kidney for 41 patients (51.2%). Of these patients, 58 (72.5%) had de novo metastatic disease, while 22 (27.5%) had recurrences during follow-up. Tumor localization showed no significant association with age (p=0.684), gender (p=0.761), ECOG performance status (p=0.326), primary tumor surgery (p=0.697), or lung metastasis (p=0.495). However, a significant association was found with liver metastasis (p=0.032). There was no significant difference in median survival between right and left-sided tumors (p=0.266). Conclusion: In our study, survival showed no correlation with tumor lateralization in metastatic RCC.
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