Prometryne is a methylthio-s-triazine herbicide used to control annual broadleaf and grass weeds in many cultivated plants. Significant traces are documented in environment, mainly water, soil and ...plants used for human and domestic animal nutrition. Data on the toxic effects of prometryne and other methylthio-s-triazine have scorcely been published. The goal of this study was to investigate if prometryne, applied orally, could induce DNA damage in mouse leukocytes, in subchronical
in vivo
experimental design. Three different doses of prometryne were applied
per os
repeatedly every 48 hours. After the 7th dose (day 14) and the 14th dose (day 28) blood leucocytes were analyzed by alkaline Single Cell Gel Electrophoresis (Comet) assay. The results of three different comet parameters showed general increase in Olive tail moment, tail length and tail intensity values in treated groups of animals. The increase in measured values was almost proportional to the dose received and the time of exposure. We conclude that prometryne or its metabolic residues have the potential to induce processes that cause genotoxic effects on leukocytes on mice in
in vivo
repeated exposure.
Summarized text of Croatian Consensus Conference on Viral Hepatitis of 2009 comprises the following chapters: 1) Epidemiology, 2) Clinical Picture, 3) Diagnostic Procedure, 4) Aims of Treatment of ...Viral Hepatitis, 5) Terminology, 6) Medicaments (6.1. Interferon, 6.2. Analogues of Nucleozides and Nucleotides), 7) Hepatitis B (7.1. Serologic and Molecular HBV Diagnostics, 7.2. Terminology, 7.3.Whom to Treat? 7.4. Therapy), 8) Hepatitis C (8.1. Serologic and Molecular HCV Diagnostics, 8.2. Terminology, 8.3. Whom to Treat? 8.4. Therapy). Clinical, laboratory and histologic assessment of patients with chronic viral hepatitis (algorythm of pretherapeutic treatment; histologic evaluation) and notions related to therapy of viral hepatitis (category of the patient and category of the response to treatment) are presented in related tables.
Toxoplasma gondii jedan je od glavnih oportunistički patogena u bolesnika zaraženih HIV-om. Prevalencija zaraze parazitom T. gondii u HIV-bolesnika u Hrvatskoj do sada nije poznata. Cilj rada bio je ...utvrditi seroprevalenciju toksoplazmoze u HIV-bolesnika u Hrvatskoj. Uključeno je 166 HIV-bolesnika i 219 dobrovoljnih davatelja krvi (DDK) kao zdrava kontrola. Enzimskim imunotestom određena su protutijela IgM, IgG i IgA na T. gondii. Seroprevalencija toksoplazmoze u HIV-bolesnika iznosi 51,8 %, a u DDK 52,5 %. Protutijela IgM bila su reaktivna samo u 2 HIV-bolesnika i 2 DDK, a IgA u 2 HIV-bolesnika i 1 DDK. Prema rizičnom ponašanju za HIV-infekciju utvrđeno je da muškarci koji imaju spolne odnose s drugim muškarcima imaju statistički značajno višu prevalenciju (66,7 %) i 2,4 puta veću šansu za toksoplazmozu nego drugi HIV-bolesnici (OR 2,37; 95 % IP 1,12–5,13). Rezultati su analizirani prema dobi, spolu, geografskom podrijetlu i za HIV-bolesnike broju CD4+ limfocita T i nisu nađene statistički značajne razlike ni za jedan parametar. Ovo je prvo istraživanje u kojem je utvrđena seroprevalencija toksoplazmoze u HIV-bolesnika u Hrvatskoj.
Hrvatske konsenzus konferencije o virusnim hepatitisima održane su 2005. i 2009. g. (1). S obzirom na brojne nove spoznaje o epidemiologiji, dijagnostici i liječenju virusnih hepatitisa (poglavito ...kroničnog hepatitisa C genotipa 1) u protekle četiri godine, 28. veljače 2013. g. održana je nova Hrvatska konsensus konferencija o virusnim hepatitisima u Zagrebu. Sažeti tekst ove Hrvatske konsenzus konferencije o virusnim hepatitisima sadrži prikaz novih spoznaja o epidemiologiji virusnih hepatitisa, serološkoj i mo¬lekularnoj dijagnostici virusnih hepatitisa, određivanju polimorfizma promotora gena za IL-28, procjeni stadija fibroze, algoritmu dijagnostičkog praćenja bolesnika, liječenju kroničnog hepatitisa C (genotipovi 1-6) i hepatitisa B, liječenju specijalnih populacija (djeca, bolesnici na dijalizi, bolesnici liječeni transplantacijom, osobe s HIV/HCV koinfekcijom) i nuspojavama liječenja.
