We report the case of a 54-year-old man with asymptomatic isolated dissection of the superior mesenteric artery (SMA) found in CT. Three-dimensional reconstructed CT showed that the true lumen was ...not compressed by the false lumen but no aneurysm had formed. Conservative therapy with an anti platelet agent was chosen, because the patient was asymptomatic for intestinal ischemia. CT 1 year later showed a regressed, completely thrombosed false lumen and a normally dilated true lumen at the origin of the SMA. Solitary SMA dissection is rare. In some cases massive small intestine resection is required, but some cases reported well to anti platelet or anti coagulant therapy, as in our case.
Phase I study on BRL 25000, a 2 to 1 ratio of amoxicillin (AMPC) and clavulanic acid (CVA) was carried out in healthy male volunteers and the following results were obtained. After oral ...administration of BRL 25000, the serum concentration of AMPC and CVA was distributed according to the dose volume and the half lives were almost 1 hr. Urinary recovery rate was about 60% in AMPC, about 30% in CVA. On consecutive administration of BRL 25000 375 mg tablets t. i. d. for 7 days, no accumulation was detected in serum and urine. One volunteer after 2 tablets, 3 volunteers after 3 tablets of BRL 25000 oral administration complained of a slight nausea which disappeared immediately. In one volunteer the BUN was slightly elevated after consecutive administration for 7 days, but returned to a normal value at re-study 1 week later.
The microbial quality control of 41 solutions or suspensions for internal use and of 8 radiopaque media was investigated by the test method described in PAB Notification No.297 (valid on April 1, ...1976). All of the 49 pharmaceutical products tested met the standard requirements provided in the Notification, so that they are considered to be under good microbial quality control. Most of the sample solutions of radiopaque media were turbid and were difficult to be put to the test for microbial count. In this point, the test method for the microbial count is desired to be improved. A test method of estimating the possible antimicrobial activity of products is also desired to be standardized, because the antimicrobial activity may affect the final results of the tests in the Notification.
Twenty one pharmaceutical products which had shown a positive reaction of microbial contamination in all of the 5 culture media in the previous sterility test were selected for this test. This paper ...compares the levels of microbial contamination in the latest test with those in the previous test conducted 3 years before, and also analyzes the tendency of the recent quality control of pharmaceutical products in relation to microbial contamination. In the latest study, total aerobic microbial count of more than 10000/g was observed in 3 of the 21 products, showing the same incidence as in the previous test. Total aerobic microbial count of less than 1, 000/g was observed in 15 products, as compared to 10in the previous test. Coliform organisms were detected in 2 products, compered to 6 in the preceding study.
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