New series of 5-(morpholinosulfonyl) isatin derivatives were designed and synthesized. The new compounds were characterized on the basis of spectral and elemental analyses. They were examined for ...their cytotoxic effects using SRB assay on four cancer cell lines HepG2, HCT116, CACO and MCF-7 in addition to the non-cancerous human cell line. They were non cytotoxic towards the normal derived cell line (IC50 value > 130 μM). Compounds 3, 6, 10 and 11 showed IC50 values less than 10 μM on three of the tested cell lines HepG2, HCT116 and CACO. Compounds 2h, 5, and 7b showed IC50 values less than or nearly equal 10 μM on HepG2, CACO and HCT116 respectively. Compounds 3 and 6 revelaed IC50 values less than 12 μM on MCF7. These obtained IC50 values are comparable with that of doxrubicin as it has showed IC50 range from 4.5 to 8.28 μM on the tested cell lines. All these promising derivatives showed inhibitory activity against EGFR with IC50 values less than 2 μM. The most potent EGFR inhibitors 7b (IC50 = 46 nM) and 10 (IC50 = 23 nM) showed to cause cell cycle arrest at G2/M phase and induce apoptosis. Molecular docking studies also were simulated to put insight and make better understanding to their structural features.
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•A novel series of (morpholinosulfonyl)isatins were designed and synthesized.•Anticancer activity evaluation of the new compounds was performed against MCF7, HepG2, CACO and HCT116 cancer cells.•Seven new compounds 2h, 3, 5, 6, 10 and 11 showed to be the best active anticancer agents.•Compounds 7b and 10 showed the most potent inhibitory activities against EGFR.•Cell cycle analysis revealed apoptosis induction ability of 7b and 10.
•Effect of fiber dosage and length in UHPC was explored.•Chloride ions penetration and corrosion degradation in UHPC were quantified.•Superior flexural behavior and toughness of UHPC were ...assessed.•Fiber-reinforced UHPC exhibits great potential in civil infrastructure applications.
Ultra-high performance concrete (UHPC) is a new generation of steel fiber-reinforced concrete with superior mechanical and durability properties. However, limited data is available on the influence of the steel fiber length and dosage on UHPC mechanical and durability performance. Therefore, in this study, a number of UHPC mixtures with varying steel fiber lengths (8mm (0.31in), 12mm (0.47in) and 16mm (0.62in)) and dosages (1%, 3% and 6%) by mixture volume were tested. Mechanical properties of UHPC including compressive, splitting tensile and flexural strengths were assessed. Moreover, its resistance to chloride ions penetration and mechanical degradation under various chloride exposures (i.e. 3.5% and 10%) were evaluated. Results showed an increase in mechanical properties as the fiber dosage increased. UHPC mixtures incorporating short steel fibers exhibited enhanced flexural properties compared to that of mixtures with similar volume of longer steel fibers. At higher fiber dosage, UHPC mixtures exhibited relatively improved durability. Moreover, no degradation in UHPC mechanical properties was observed after exposure to various chloride ions solutions.
Hemorrhage is the major hindrance over the wound healing, which triggers microbial infections and might provoke traumatic death. Herein, new hemostatic and antibacterial PVA/Kaolin composite sponges ...were crosslinked using a freeze-thawing approach and boosted by penicillin-streptomycin (Pen-Strep). Physicochemical characteristics of developed membranes were analyzed adopting Fourier transformed infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), a thermal gravimetric analyzer (TGA), and differential scanning calorimetry (DSC). Furthermore, the impacts of kaolin concentrations on porosity, swelling behavior, gel fraction, and degradation of the membranes were investigated. SEM analyses revealed a spongy-like structure of hydrogels associated with high dispersion of kaolin inside PVA matrix. The thermal characteristics of PVA/Kaolin were significantly ameliorated compared to the prime PVA. Moreover, the results exhibited significant variations of swelling performance, surface roughness and pore capacity due to the alterations of kaolin contents. Besides, the adhesive strength ability was manifestly enhanced for PVA-K0.1 sponge. Biomedical evaluations including antibacterial activity, blood clotting index and thrombogenicity of the membranes were studied. The contact of PVA/Kaolin to blood revealed notable augmentation in blood clotting. Furthermore, the incorporation of kaolin into PVA presented mild diminution in antibacterial activities. Moreover, PVA/Kaolin composites illustrated no cellular toxicity towards fibroblast cells. These remarkable features substantiate that the PVA-K0.1 sponge could be applied as a multifunctional wound dressing.
Polymers are often used in medical applications, therefore, some novel polymers and their interactions with photons have been studied. The gamma-ray shielding parameters for Polymethylpentene (PMP), ...Polybutylene terephthalate (PBT), Polyoxymethylene (POM), Polyvinylidenefluoride (PVDF), and Polychlorotrifluoroethylene (PCTFE) polymers were determined using the Geant4 simulation and discussed in the current work. The mass attenuation coefficients (μ/ρ) were simulated at low and high energies between 0.059 and 1.408 MeV using different radionuclides. The accuracy of the Geant4 simulated results were checked with the XCOM software. The two different methods had good agreement with each other. Exposure buildup factor (EBF) was calculated and discussed in terms of polymers under study and photon energy. Effective atomic number (Zeff) and electron density (Neff) were calculated and analyzed at different energies. Additionally, the half-value layer (HVL) of the polymers was evaluated, and the results of this parameter showed that PCTFE had the highest probability of interaction with gamma photons compared to those of the other tested polymers.
A new series of pyrazole
⁻
and pyrazolo1,5-
pyrimidine
⁻
were synthesized by using a simple, efficient procedure, and screened for their in-vitro antimicrobial and antitumor activities. Symmetrical ...and asymmetrical 3,6-diarylazo-2,5,7-triaminopyrazolo1,5-
pyrimidine were synthesized by the conventional method and also subjected to microwave irradiation and under ultrasound conditions. The biological results revealed that most of the tested compounds proved to be active as antibacterial and antifungal agents. The antitumor activity of the synthesized compounds was evaluated against human cancer cell lines, MCF-7, HCT-116, and HepG-2, as compared with Doxorubicin as a control.
In the present work, high density polyethylene (HDPE) matrix mixed with micro-sized and nano-sized Cadmium oxide (CdO) particles of different concentrations were prepared by compression molding ...technique. The aim of the study is to investigate the effect of particle size and weight percentage of CdO particles on the gamma radiation shielding ability of CdO/HDPE composites. The mass attenuation coefficients of pure HDPE, micro-CdO/HDPE and nano-CdO/HDPE composites were evaluated at photon energies ranging from 59.53 keV to 1408.01 keV using standard radioactive point sources
Am,
Ba,
Cs,
Co and
Eu. Adding micro and nano CdO particles to the HDPE matrix clearly increases the mass attenuation coefficients of the composites and the improvement is more significant at low γ-ray energies. The effect of particle size of CdO filler has an important role on the shielding ability of the composite. The experimental results reveal that, the composites filled with nano-CdO have better γ-radiation shielding ability compared to that filled with micro-CdO at the same weight fraction. A relative increase rate of about 16% is obtained with nano-CdO content of 40 wt% at 59.53 keV, which attributed to the higher probability of interaction between γ-rays and nanoparticles. From this study, it can be concluded that nano-CdO has a good performance shielding characteristic than micro-CdO in HDPE based radiation shielding material.
This paper presents a numerical investigation of the flow of a non-Newtonian tangent hyperbolic nanofluid over a nonlinearly stretched surface, taking into account factors such as thermal radiation, ...prescribed surface temperature, and a chemical reaction mechanism. Furthermore, the analysis includes the consideration of both viscous dissipation and the influence of a magnetic field within a Darcy porous medium. A mathematical framework for addressing the issue, rooted in the principles of conserving momentum, energy, and mass. The MATHEMATICA tools were employed to apply the shooting technique in order to solve the modeled equations describing the temperature, velocity, and concentration fields of the proposed physical system. Graphs are used to illustrate how certain key parameters affect the profiles of concentration, velocity, and temperature. Data tables are utilized to display information pertaining to the local Nusselt number, local Sherwood number, and local skin friction coefficient. The present results have been confirmed through a comparison with previously published findings. This research holds significant importance as it focuses on the extensive utilization of tangent hyperbolic nanofluids in cooling electronic components that produce substantial heat during their operation. The observed pattern indicates that as the local Weisbsenberg number, magnetic number, local porous parameter, and power law index increase, there is a reduction in the boundary layer thickness. Conversely, in the instances of concentration and temperature distributions, an escalation in these parameters leads to an expansion of the boundary layer thickness.
The objective of this paper is to examine the flow of a non-Newtonian Maxwell fluid induced by a permeable stretching sheet in motion within a porous medium. The research incorporates the ...Cattaneo-Christov heat flux model to study the heat transfer process. The utilization of the Cattaneo-Christov heat flux approach becomes relevant in scenarios involving materials with high thermal conductivity or during short time intervals. Consequently, the current investigation holds significant importance. It is assumed that the viscosity of the Maxwell fluid changes exponentially as the temperature changes. The modeling of the physical phenomena being investigated takes into account the effects of a magnetic field, thermal radiation, velocity, and thermal slip conditions. In this study, the viscous dissipation phenomenon is taken into account because it can have notable impacts on the temperature and viscosity of the fluid, and is known to play a crucial role in fluid flow phenomena. The equations developed to model fluid flow are transformed into nonlinear ordinary differential equations through the use of appropriate similarity transformations. The focus of the research revolves around investigating the numerical solution of ordinary differential equations accompanied by boundary conditions using the shooting technique. The findings are then showcased via tables and graphs and scrutinized in order to arrive at conclusions. Furthermore, the precision of the present findings was evaluated by contrasting the heat transfer rate with outcomes that were previously published. Based on the obtained outcomes, it can be concluded that both the Eckert number and thermal radiation have a comparable enhancing influence, whereas the thermal relaxation parameter and thermal slip parameter exhibit opposing effects.
A comprehensive study encompassing a general development and a presentation of results for the influence of the chemical reaction on the laminar Cross fluid flow and heat mass transfer is made here. ...The motion of the fluid is assumed due to the stratified stretching sheet which embedded in a porous medium. Some of important characteristics of the fluid such as the variable thermal conductivity and its dependence on the temperature field are mentioned. Accordingly, some account of the possible effects of heat generation on heat mass transfer in fluid flows is given. Numerical treatments have been introduced for the resulting coupled ordinary differential equations. Then, the results of the variation in the velocity profile, the temperature profile and the concentration profile due to porous parameter, thermal conductivity parameter, heat generation parameter, thermal stratification parameter and chemical reaction parameter are presented graphically. At the proposed physical conditions for the problem, the Sherwood number, the Nusselt number or the temperature gradient and the local skin friction coefficient were measured. It is interesting to observe that, both the solutal and the thermal stratification phenomena plays a dominant role in the mechanism of heat and mass transfer. Also, regarding the warming factors within the thermal boundary layer, both Darcy parameter and heat generation parameter have been proposed which are of special interest in heat transfer problems. Finally, the results pointed out the efficiency of the proposed numerical method, where it gives a good representation describing the mechanism of the flow, heat and mass transfer.
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