Introduction
Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in ...young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS).
Design
NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14.
Setting/participants
98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD.
Intervention
The intervention strategy was the assignment of a LGIMD or a control diet.
Outcome measures
The main outcome measure was NAFLD score, defined by LUS.
Results
After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (-4.14, 95% CI -6.78,-1.49) was observed, and became more evident at the sixth month (-4.43, 95%CI -7.15, -1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed.
Conclusions
LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.
Cognitive frailty is a condition recently defined by operationalized criteria describing the simultaneous presence of physical frailty and mild cognitive impairment (MCI). Two subtypes for this ...clinical construct have been proposed: "potentially reversible" cognitive frailty (physical frailty plus MCI) and "reversible" cognitive frailty (physical frailty plus pre-MCI subjective cognitive decline). Here the prevalence of a potentially reversible cognitive frailty model was estimated. It was also evaluated if introducing a diagnosis of MCI in older subjects with physical frailty could have an additive role on the risk of dementia, disability, and all-cause mortality in comparison with frailty state or MCI condition alone, with analyses separately performed for inflammatory state.
In 2,373 individuals from the population-based Italian Longitudinal Study on Aging with a 3.5-year-follow-up, we operationally categorized older individuals without dementia into four groups: non-frail/non-MCI, non-frail/MCI, frail/non-MCI, and frail/MCI.
The prevalence of potentially reversible cognitive frailty was 1%, increasing with age and more represented in women than in men, and all groups were associated with significant increased incident rate ratios of dementia, disability, and mortality. A significant difference in rates of disability has been found between the MCI and non-MCI groups (contrasts of adjusted predictions: 0.461; 95% confidence interval: 0.187-0.735) in frail individuals with high inflammatory states (fibrinogen >339 mg/dL).
In older individuals without dementia and with elevated inflammation, a potentially reversible cognitive frailty model could have a significant additional predictive effect on the risk of disability than the single conditions of frailty or MCI.
Results obtained by the RPC ECOgas@GIF++ Collaboration, using Resistive Plate Chambers operated with new, eco-friendly gas mixtures, based on tetrafluoropropene and carbon dioxide, are shown and ...discussed in this paper. Tests aimed to assess the performance of this kind of detectors in high-irradiation conditions, analogous to the ones foreseen for the coming years at the Large Hadron Collider experiments, were performed, and demonstrate a performance basically similar to the one obtained with the gas mixtures currently in use, based on tetrafluoroethane, which is being progressively phased out for its possible contribution to the greenhouse effect. Long term aging tests are also being carried out, with the goal to demonstrate the possibility of using these eco-friendly gas mixtures during the whole High Luminosity phase of the Large Hadron Collider.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Resistive Plate Chamber detectors are largely used in current High Energy Physics experiments, typically operated in avalanche mode with large fractions of Tetrafluoroethane (C2H2F4), a gas recently ...banned by the European Union due to its high Global Warming Potential (GWP). An intense R&D activity is ongoing to improve RPC technology in view of future HEP applications. In the last few years the RPC EcoGas@GIF++ Collaboration has been putting in place a joint effort between the ALICE, ATLAS, CMS, LHCb/SHiP and EP-DT Communities to investigate the performance of present and future RPC generations with eco-friendly gas mixtures. Detectors with different layout and electronics have been operated with ecological gas mixtures, with and without irradiation at the CERN Gamma Irradiation Facility (GIF++). Results of these performance studies together with plans for an aging test campaign are discussed in this article.
FCC-hh: The Hadron Collider Altmannshofer, W.; Arsenyev, S. A.; Azatov, A. ...
The European physical journal. ST, Special topics,
07/2019, Letnik:
228, Številka:
4
Journal Article, Publication
Recenzirano
Odprti dostop
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. ...The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries.
In the last few years, an intense R &D activity on particle detectors for future HEP applications has been carried on with the aim of developing new techniques as well as studying the performance of ...already existing detectors when operated in a high rate environment. As for Resistive Plate Chamber detectors, the main challenges to face are the improvement of their detection capabilities and longevity at very high-rates, and the search for new eco-friendly gasmixtures free from greenhouse components. Results obtained in the framework of the RPC ECOGas@GIF++ Collaboration on a thin-Resistive Plate Chamber exposed at the CERN Gamma Irradiation Facility and operated with eco-friendly gas mixtures based on Tetrafluoropropene and Carbon dioxide will be discussed in this paper.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We have developed an artificial neural network prediction model for end-stage kidney disease (ESKD) in patients with primary immunoglobulin A nephropathy (IgAN) using a retrospective cohort of 948 ...patients with IgAN. Our tool is based on a two-step procedure of a classifier model that predicts ESKD, and a regression model that predicts development of ESKD over time. The classifier model showed a performance value of 0.82 (area under the receiver operating characteristic curve) in patients with a follow-up of five years, which improved to 0.89 at the ten-year follow-up. Both models had a higher recall rate, which indicated the practicality of the tool. The regression model showed a mean absolute error of 1.78 years and a root mean square error of 2.15 years. Testing in an independent cohort of 167patients with IgAN found successful results for 91% of the patients. Comparison of our system with other mathematical models showed the highest discriminant Harrell C index at five- and ten-years follow-up (81% and 86%, respectively), paralleling the lowest Akaike information criterion values (355.01 and 269.56, respectively). Moreover, our system was the best calibrated model indicating that the predicted and observed outcome probabilities did not significantly differ. Finally, the dynamic discrimination indexes of our artificial neural network, expressed as the weighted average of time-dependent areas under the curve calculated at one and two years, were 0.80 and 0.79, respectively. Similar results were observed over a 25-year follow-up period. Thus, our tool identified individuals who were at a high risk of developing ESKD due to IgAN and predicted the time-to-event endpoint. Accurate prediction is an important step toward introduction of a therapeutic strategy for improving clinical outcomes.
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Due to the recent restrictions deriving from the application of the Kyoto protocol, the main components of the gas mixtures presently used in the Resistive Plate Chambers systems of the LHC ...experiments will be most probably phased out of production in the coming years. Identifying possible replacements with the adequate characteristics requires an intense R&D activity, which was recently started, in collaborations with various experiments. Possible new gases have been proposed and are thoroughly investigated. Some tests on one of the most promising candidate?HFO-1234ze, an allotropic form of tetrafluoropropane?have already been reported. Here an innovative approach, based on the use of Helium, to solve the problem related to the high operating voltage needed to operate the chambers with HFO-1234ze based gas mixtures, is discussed and the first results are shown.
The series of upgrades to the Large Hadron Collider, culminating in the High Luminosity Large Hadron Collider, will enable a significant expansion of the physics program of the CMS experiment. ...However, the accelerator upgrades will also make the experimental conditions more challenging, with implications for detector operations, triggering, and data analysis. The luminosity of the proton–proton collisions is expected to exceed 2–3×1034 cm−2s−1 for Run 3 (starting in 2022), and it will be at least 5×1034 cm−2s−1 when the High Luminosity Large Hadron Collider is completed for Run 4. These conditions will affect muon triggering, identification, and measurement, which are critical capabilities of the experiment. To address these challenges, additional muon detectors are being installed in the CMS endcaps, based on Gas Electron Multiplier technology. For this purpose, 161 large triple-Gas Electron Multiplier detectors have been constructed and tested. Installation of these devices began in 2019 with the GE1/1 station and will be followed by two additional stations, GE2/1 and ME0, to be installed in 2023 and 2026, respectively. The assembly and quality control of the GE1/1 detectors were distributed across several production sites around the world. We motivate and discuss the quality control procedures that were developed to standardize the performance of the detectors, and we present the final results of the production. Out of 161 detectors produced, 156 detectors passed all tests, and 144 detectors are now installed in the CMS experiment. The various visual inspections, gas tightness tests, intrinsic noise rate characterizations, and effective gas gain and response uniformity tests allowed the project to achieve this high success rate.
ALICE (A Large Ion Collider Experiment) studies the Quark-Gluon Plasma (QGP): a deconfined state of nuclear matter obtained in ultra-relativistic heavy-ion collisions. One of the key probes for QGP ...characterization is the study of quarkonia and open heavy flavour production, of which ALICE exploits the muonic decay. In particular, a set of Resistive Plate Chambers (RPCs), placed in the forward rapidity region of the ALICE detector, is used for muon identification purposes.
The correct operation of these detectors is ensured by the choice of the proper gas mixture. Currently they are operated with a mixture of C2H2F4, i-C4H10 and SF6 but, starting from 2017, new EU regulations have enforced a progressive phase-out of C2H2F4 because of its large Global Warming Potential (GWP), which is making it difficult and costly to purchase. Moreover, CERN asked LHC experiments to reduce greenhouse gases emissions, to which RPC operation contributes significantly.
A possible candidate for C2H2F4 replacement is the C3H2F4 (diluted with other gases, such as CO2), which has been extensively tested using cosmic muons. Promising gas mixtures have been devised; the next crucial steps are the detailed in-beam characterization of such mixtures as well as the study of their performance under increasing irradiation levels.
This contribution will describe the methodology and results of beam tests carried out at the CERN Gamma Irradiation Facility (equipped with a high activity 137Cs source and muon beam) with an ALICE-like RPC prototype, operated with several mixtures with varying proportions of CO2, C3H2F4, i-C4H10 and SF6 . Absorbed currents, efficiencies, prompt charges, cluster sizes, time resolutions and rate capabilities will be presented, both from digitized (for detailed shape and charge analysis) and discriminated (using the same front-end electronics as employed in ALICE) signals.
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