Que la rougeur des hommes paraisse beaucoup moins repérable que celle des femmes ne saurait étonner : cette dernière est en effet, dans l’imaginaire du siècle des Lumières, inséparable d’une “nature” ...féminine que les médecins du 18 e n’ont eu de cesse de définir. Les romans et les discours du siècle réservent cependant une place et spécifient un empourprement masculin que le cas du ministre Turgot permet par ailleurs de documenter.
Several matrix metalloproteinases (MMPs) are overexpressed in lung cancer and may serve as potential targets for the development of bioactivable probes for molecular imaging.
To characterize and ...monitor the activity of MMPs during the progression of lung adenocarcinoma.
K-rasLSL-G12D mice were imaged serially during the development of adenocarcinomas using fluorescence molecular tomography (FMT) and a probe specific for MMP-2, -3, -9 and -13. Lung tumors were identified using FMT and MRI co-registration, and the probe concentration in each tumor was assessed at each time-point. The expression of Mmp2, -3, -9, -13 was quantified by qRT-PCR using RNA isolated from microdissected tumor cells. Immunohistochemical staining of overexpressed MMPs in animals was assessed on human lung tumors.
In mice, 7 adenomas and 5 adenocarcinomas showed an increase in fluorescent signal on successive FMT scans, starting between weeks 4 and 8. qRT-PCR assays revealed significant overexpression of only Mmp-13 in mice lung tumors. In human tumors, a high MMP-13 immunostaining index was found in tumor cells from invasive lesions (24/27), but in none of the non-invasive (0/4) (p=0.001).
MMP-13 is detected in early pulmonary invasive adenocarcinomas and may be a potential target for molecular imaging of lung cancer.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Le roman de Gervaise de Latouche connut plusieurs suites : les Mémoires de Suzon (1776) et l’ Histoire de Marguerite (1784), deux textes qui laissent au lecteur un curieux goût d’appauvrissement ...littéraire par rapport à leur modèle original. Mais qu’est-ce qu’un texte pornographique « réussi » ? Comment dans le mauvais genre juger de la valeur ?
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