Abstract Hematopoietic stem cell transplantation (HSCT) has improved outcomes for severe hematologic, malignant, and immune disorders, yet poses an increased risk of subsequent malignancies. This ...study aimed to examine the risk of skin cancer following HSCT and identify potential risk factors. The search was conducted in MEDLINE, EMBASE, and CINAHL databases until December 2023. Cohort studies reporting standardized incidence ratios (SIRs) for post‐HSCT skin cancer or investigating risk factors were included. SIRs, or hazard ratios (HRs) with 95% confidence interval (CI), were calculated using random‐effects inverse‐variance models. Outcome endpoints were SIRs of skin cancer post‐HSCT and risk factors, including gender, chronic graft‐versus‐host disease (cGVHD), voriconazole exposure, and total body irradiation (TBI). Twenty‐six studies involving 164,944 HSCT recipients (allogeneic HSCT, n = 68,637; autologous HSCT, n = 95,435; mean age: 38.5 ± 13.8 years; 71,354 females 43.3%) were analyzed. Overall, SIR for skin cancer post‐HSCT was 7.21 (95% CI 3.98–13.08), with SIRs of 2.25 (95% CI: 1.37–3.68) for autologous HSCT, and 10.18 (95% CI 5.07–20.43) for allogeneic HSCT. Risk factors for skin cancer risk included cGVHD (HR = 2.86 95% CI: 2.01–4.07), specifically for basal cell and squamous cell carcinoma (SCC) (HR = 1.80 95% CI: 1.31–2.46 and HR = 3.68 95% CI: 2.39–5.68, respectively), male gender (HR = 1.56 95% CI: 1.15–2.13), especially for SCC (HR = 1.70 95% CI: 1.03–2.80), and voriconazole exposure (HR = 2.01 95% CI: 1.12–3.61). TBI showed no statistically significant association with subsequent skin cancer (HR = 1.12 95% CI: 0.73–1.71). These findings highlight the importance of rigorous skin cancer surveillance and preventive strategies in HSCT recipients, particularly in male individuals undergoing allogeneic transplants and those with identifiable risk factors, to enable early detection and intervention.
IMPORTANCE: A novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently been identified as the cause of a pandemic called coronavirus disease 2019 (COVID-19). ...In this context, some associated skin diseases have been described. Cutaneous lesions referred to as acute acro-ischemia have been reported as a possible sign of COVID-19 in adolescents and children. OBJECTIVE: To evaluate the pathogenesis of these newly described acute acral lesions. DESIGN, SETTING, AND PARTICIPANTS: This prospective case series was conducted at La Fe University Hospital, a tertiary referral hospital in Valencia, Spain, between April 9 and April 15, 2020. Among 32 referred patients, 20 children and adolescents with new-onset inflammatory lesions did not have a diagnosis. EXPOSURES: Patients were not exposed to any drug or other intervention. MAIN OUTCOMES AND MEASURES: We performed reverse transcriptase–polymerase chain reaction for SARS-CoV-2 and a range of blood tests for possible origins of the lesions. Skin biopsies were performed in 6 patients. RESULTS: Of the 20 patients enrolled, 7 were female and 13 were male, with an age range of 1 to 18 years. Clinical findings fit into the following patterns: acral erythema (6 patients), dactylitis (4 patients), purpuric maculopapules (7 patients), and a mixed pattern (3 patients). None of the patients had remarkable hematologic or serologic abnormalities, including negative antibodies to SARS-CoV-2. Biopsies performed in 6 patients showed histologic findings characteristic of perniosis. CONCLUSIONS AND RELEVANCE: The clinical, histologic, and laboratory test results were compatible with a diagnosis of perniosis, and no evidence was found to support the implication of SARS-CoV-2 infection.
The management of actinic keratoses and field cancerization is a therapeutic challenge. Tirbanibulin 1% ointment is a promising new drug for use on specific parts of the body or in patients who are ...refractory or reluctant to use other more aggressive treatments.
Zoon’s vulvitis in association with severe vulvodynia Abril-Pérez, Carlos; Palacios-Diaz, Rodolfo David; Torres-Navarro, Ignacio ...
American journal of obstetrics and gynecology,
09/2022, Letnik:
227, Številka:
3
Journal Article
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