Daratumumab was associated with impressive antitumor responses, including complete and very good partial responses, in heavily pretreated patients with myeloma. Infusion reactions were the main ...adverse effect.
Current therapies, including proteasome inhibitors and immunomodulatory agents, have improved outcomes substantially in patients with multiple myeloma.
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Unfortunately, the majority of these patients have a relapse and have limited treatment options after exposure to these classes of agents.
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Patients with disease that is refractory to both proteasome inhibitors and immunomodulatory drugs have poor prognoses; the estimated median overall survival is 9 months, and the estimated event-free survival is 5 months at best.
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CD38 is a 45-kD, type II transmembrane glycoprotein that associates with cell-surface receptors in lipid rafts, regulates cytoplasmic Ca
2+
flux, and mediates signal transduction in lymphoid . . .
Abstract
We present 2D global MHD simulation results of the optimized start-up scenarios for the spherical tokamak to maximize the ion heating energy determined by the value of the poloidal private ...flux during the merging start-ups. The series of simulations has successfully revealed the dependence of the poloidal private flux on the in-vessel poloidal coils’ separation length under the fixed amount of coils’ magnetic energy. The radial and azimuthal locations of the internal coils need to be optimized to maximize high private flux and consequently high ion heating energy. In the case of a two poloidal field (PF) coils system, the private flux and ion heating energy increase with the coils’ separation length. Installing two additional PF coils improves the private flux significantly, even if the coils’ separation length is short.
In order to investigate the stability of qualitative and quantitative traits and choose the most appropriate cultivation method and irrigation regime in rice plants, the experiment was conducted in ...the form of a split-plot design based on a randomized complete block design in three replications and in two cropping years. The results of compound analysis indicated that the effect of year × irrigation regimes in terms of traits, grain yield, rainfall, productivity 2, number of full grains, number of hollow grains, harvest index, percentage of crushed grains and yield of white rice, the effect of year × Cultivation method characteristics in terms of water consumption, rainfall, productivity 1, number of tillers, plant height, spike length, number of hollow grains, thousand seed weight, small grain percentage and white rice yield and the effect of irrigation regime × cultivation methods in terms of all Traits except traits productivity 2 were significant. The results of the mean comparison of the interaction effect of irrigation regimes and cultivation methods also showed that treatments T1W1, T2W1 and T1W3 are favorable for all evaluated traits. Based on the table of correlation coefficients, correlation diagram and map of the intensity of the correlation in the years of the experiment, it is possible to report the correlation of the grain yield trait with the traits of water consumption, rainfall, plant height, 100- seed weight, full grain number and white rice yield. Also, traits productivity 1, productivity 2 and small grain percentage showed a positive correlation and a negative correlation of these three traits with most of the traits evaluated in the experiment was observed. Based on the analysis of the main components, the first four main components explained the most data variance, and T2W2 and T2W3 treatments were identified as suitable treatments for rice cultivation in terms of the first and second main components.
Abstract A split-plot experiment was conducted in a randomized complete block design with three replications in two cropping years at Mazandaran Rice Research Institute to study cultivation and ...irrigation regimes. The main factor is three-level irrigation regimes, permanent irrigation throughout the day (T1), irrigation two days after water disappears from the soil (T2) and permanent soil saturation (T3) the second factor is three-level cultivation methods., Plowless cultivation (W1), stack 60 cm (W2), and stack 80 cm (W3). Based on the results obtained from the combined analysis, the effect of the year was significant in terms of rainfall, productivity 2, number of tillers, number of empty grains, 1000-grain weight, percentage of the crushed grain, and white rice yield. The effect of the main factor was significant for all traits except productivity 1 and plant height. Based on the results of comparing the mean effect of year × treatment, four treatments, without plowing with permanent irrigation throughout the day in the first and second year of the experiment, cultivation without plowing with irrigation two days after water disappears from the soil in the second year of experiment and cultivation without Plowing with permanent saturated irrigation in the first and second years of the experiment was identified in terms of grain yield as suitable planting methods with appropriate irrigation regimes. Based on the results obtained from the polygon view in different years of the experiment, T3W1, T3W2, and T1W1 treatments can be suggested as desirable treatments in terms of irrigation regimes and cultivation methods in this rice cultivar. According to the ranking diagram of treatments based on traits in the years of experimentation, T1W1, T2W2 and T1W3 were introduced as the most desirable treatments for cultivating this rice cultivar.
Resumo Um experimento de parcelas subdivididas foi conduzido em um delineamento de blocos completos casualizados com três repetições em dois anos de cultivo no Mazandaran Rice Research Institute para estudar os regimes de cultivo e irrigação. O principal fator são os regimes de irrigação em três níveis, irrigação permanente ao longo do dia (T1), irrigação dois dias após o desaparecimento da água do solo (T2) e saturação permanente do solo (T3); o segundo fator são os métodos de cultivo em três níveis: cultivo sem arado (W1), empilhar 60 cm (W2) e empilhar 80 cm (W3). Com base nos resultados obtidos na análise combinada, o efeito do ano foi significativo em termos de precipitação pluviométrica, produtividade 2, número de perfilhos, número de grãos vazios, peso de 1.000 grãos, porcentagem de grãos triturados e rendimento de arroz branco. O efeito do fator principal foi significativo para todas as características, exceto produtividade 1 e altura de planta. Com base nos resultados da comparação do efeito médio ano x tratamento, quatro tratamentos, sem aração com irrigação permanente ao longo do dia no primeiro e segundo ano do experimento, cultivo sem aração com irrigação dois dias após o desaparecimento da água do solo no segundo ano de experimento e cultivo sem aração com irrigação saturada permanente no primeiro e segundo ano do experimento, foi identificado em termos de produtividade de grãos como métodos de plantio adequados com regimes de irrigação adequados. Com base nos resultados obtidos na visão poligonal em diferentes anos do experimento, os tratamentos T3W1, T3W2 e T1W1 podem ser sugeridos como tratamentos desejáveis em termos de regimes de irrigação e métodos de cultivo nessa cultivar de arroz. De acordo com o diagrama de classificação dos tratamentos baseados em características nos anos de experimentação, T1W1, T2W2 e T1W3 foram introduzidos como os tratamentos mais desejáveis para o cultivo dessa cultivar de arroz.
Microelectromechanical system (MEMS)-based mass sensors are proposed as potential candidates for highly sensitive chemical and gas detection applications owing to their miniaturized structure, low ...power consumption, and ease of integration with readout circuits. This paper presents a new approach in developing micromachined mass sensors based on capacitive and piezoelectric transducer configurations for use in low concentration level gas detection in a complex environment. These micromachined sensors operate based on a shift in their center resonant frequencies. This shift is caused by a change in the sensor's effective mass when exposed to the target gas molecules, which is then correlated to the gas concentration level. In this work, capacitive and piezoelectric-based micromachined sensors are investigated and their principle of operation, device structures and configurations, critical design parameters and their candidate fabrication techniques are discussed in detail.
Abstract
Nata de coco is a fermented product made from coconut water.
Acetobacter xylinum
is used in coconut water fermentation to produce very fine cellulose fibers. This study aims to observe the ...bacterial cellulose (BC) formation with various carbon sources using the Real-Time Image Processing approach. Fermentation is stopped when the BC reaches a certain thickness. A set of tools have been modified to perform fermentation, such as using Raspberry Pi, Arduino sensors, USB Web Camera, and building a BC growth monitoring database that is integrated with PHP. The results showed the highest correlation between time and thickness for glucose, sucrose and mannitol mediums. Cluster analysis showed that glucose had three clusters, while sucrose and mannitol had two groups. The kinetic observations of BC growth on glucose, sucrose, and mannitol mediums follow the Gompertz model equation. The conclusions obtained are that glucose had the fastest adaptation phase, followed by sucrose, and mannitol. Mannitol was referred to as the carbon sources that had the longest BC formation.
System identification is an emerging field of structural engineering which plays a key role in structures of great importance such as concrete gravity dams. In this study, an artificial neural ...network (ANN) procedure is proposed for the identification of concrete gravity dams, in conjunction with a hybrid finite element–boundary element (FE–BE) analysis for the prediction of dynamic characteristics of an existing concrete gravity dam with an empty reservoir. First, a dam–reservoir interaction analysis is carried out by the hybrid FE–BE approach in the frequency domain. A two-dimensional (2D) FE model (FEM) is used for linear-elastic analysis of the gravity dam on a rigid foundation, while the unbounded reservoir with inviscid, compressible, and frictionless fluid is discretized by BEs. Various analyses are performed for different height to base width ratios of dams in terms of different wave reflection coefficient of the reservoir bottom. The use of ANNs is motivated by the approximate concepts inherent in system identification approaches, and the time-consuming repeated analyses required for dam–reservoir interacting systems. The conjugate gradient algorithm (CGA) and the Levenberg–Marquardt algorithm (LMA) are implemented for training the ANNs, using available data generated from the results of coupled dam–reservoir system analyses. The trained ANNs are then employed to compute the dynamic amplification of dam crest displacement and natural frequencies of existing concrete gravity dams through forced vibration tests. The results obtained by solving the present inverse problem are compared with existing FEM solutions to demonstrate the accuracy and efficiency of the proposed method.
New therapeutic strategies are urgently needed to improve clinical outcomes in patients with multiple myeloma (MM). Daratumumab is a first‐in‐class, CD38 human immunoglobulin G1κ monoclonal antibody ...approved for treatment of relapsed or refractory MM. Identification of an appropriate dose regimen for daratumumab is challenging due to its target‐mediated drug disposition, leading to time‐ and concentration‐dependent pharmacokinetics. We describe a thorough evaluation of the recommended dose regimen for daratumumab in patients with relapsed or refractory MM.
Abstract
Here we report global ion heating/transport characteristics of magnetic reconnection during merging spherical tokamak formation experiment on TS-6 (TS-3U). Using the 96CH/320CH ultra high ...resolution ion Doppler tomography diagnostics, the
full-
2
D
imaging measurement clearly revealed that magnetic reconnection initially forms localized hot spots in the downstream region of outflow jet with inboard/outboard asymmetry (more deposition in the high field side) but the continuous accumulation of the heating coupled with transport process expands the high temperature region globally and forms characteristic poloidally ring-like structure aligned with field lines. The dynamic ion heating/transport process is also affected by the polarity of toroidal field and poloidally tilted/rotating global structure has experimentally been found both during and after merging. The characteristic poloidal asymmetry gets flipped when toroidal field direction is reversed and it was found that higher temperature appears in the positive potential side, which is opposite to the conventional understanding/prediction of guide field reconnection. Through the parallel acceleration process coupled with global heat transport, poloidally asymmetric non-classical feature has experimentally been found for the first time.
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