Soybean is one of the major oil seed crops,which is usually intercropped with other crops to increase soybean production area and yield.However,soybean is highly sensitive to shading.It is unclear if ...soybean morphology responds to shading（i.e.,shade tolerance or avoidance）and which features may be suitable as screening materials in relay strip intercropping.Therefore,in this study,various agronomic characteristics of different soybean genotypes were analyzed under relay intercropping conditions.The soybean materials used in this study exhibited genetic diversity,and the coefficient of variations of the agronomic parameters ranged from 13.84 to 72.08%during the shade period and from 6.44 to 52.49%during the maturity period.The ratios of shading to full irradiance in stem mass fraction（SMF）were almost greater than 1,whereas opposite results were found in the leaves.Compared with full irradiance,the average stem length（SL）,leaf area ratio（LAR）and specific leaf area（SLA）for the two years（2013 and 2014）increased by 0.78,0.47 and 0.65 under shady conditions,respectively.However,the stem diameter（SD）,total biomass（TB）,leaf area（LA）,number of nodes（NN）on the main stem,and number of branches（BN）all decreased.During the shady period,the SL and SMF exhibited a significant negative correlation with yield,and the SD exhibited a significant positive correlation with yield.The correlation between the soybean yield and agronomic parameters during the mature period,except for SL,the first pod height（FPH）,100-seed weight（100-SW）,and reproductive growth period（RGP）,were significant（P〈0.01）,especially for seed weight per branch（SWB）,pods per plant（PP）,BN,and vegetative growth period（VGP）.These results provide an insight into screening the shade tolerance of soybean varieties and can be useful in targeted breeding programs of relay intercropped soybeans.
Soil organic carbon (SOC) and nitrogen (N) mineralization are important biogeochemical processes associated with soil fertility. These processes are influenced by physically, chemically, and ...biologically stabilized SOC fractions, the mechanisms of which are not well known. The present study was conducted to evaluate the combined effect of manure and mineral fertilizers on the contents of SOC fractions to promote the mineralization of SOC and N. Treatments included: i) no fertilizer control (CK); ii) a combination of mineral N, phosphorus, and potassium fertilizers (NPK); iii) manure alone (M); iv) manure combined with NPK (MNPK); and v) a high dose of manure combined with NPK (hMNPK). The combined uses of manure and mineral fertilizers (MNPK and hMNPK) enhanced the accumulation of the unprotected coarse particulate organic carbon (C) fraction (cPOC) by 44%–72% compared to CK. Manure applications (M, MNPK and hMNPK) enhanced physically microaggregate-protected organic C (µagg), physicochemically protected organic C within the microaggregate-derived silt (µsilt) fraction (H-µsilt), and physicobiochemically protected organic C within the µsilt fraction (NH-µsilt) by 30%–56%, 62%–150%, and 27%–51%, respectively. In contrast, all chemically and biochemically protected SOC fractions showed a minor response to manure application. Accumulation of cPOC, µagg, H-µsilt, and physicochemically protected organic C within the microaggregate-derived clay fraction (H-µclay) significantly contributed to the mineralization of SOC and N, resulting in a significant increase in rice grain yield with long-term manure application. In summary, long-term combined use of manure and mineral fertilizers improved SOC accumulation in unprotected and physically protected fractions, which enhanced SOC and N mineralization and benefited soil productivity in a rice-wheat cropping system.
Objective
A quarter of all cardiac tumors are malignant, and most (~ 95%) are sarcomas. It is the most aggressive malignant cardiac tumor carrying the worst prognosis. Tumor involvement with the ...vital intracardiac structures makes it difficult for complete surgical resection. We aimed to study the role of complete surgical resection and its importance in long-term outcomes.
Methods
We analyzed published literature from 2002 to 2022 using PubMed. Cases reported adult, intracardiac sarcomas, and received surgical resections were included. We reviewed 132 published case reports, including and analyzed the following variables: demographics, clinical presentations, diagnostic imaging modality, the extent of surgical resection, pathological diagnosis, tumor location, postoperative chemo-radiation therapy, and follow-up (including re-operation, local and distant recurrence).
Results
A total of 135 patients are included from 132 articles. The mean age was 46.69 (18–86) and 76 patients were females. The main complaints were dyspnea (70%) and chest pain (32%). Performed investigations were transthoracic echocardiography (TTE) in 114/135 (84%), computer tomography (CT) scan 89/135 (66%), trans-esophageal echocardiography (TOE) 22%, and cardiac magnetic resonance imaging (MRI) 29%. The most common location was the atrium (left 46%, right 30%). Complete surgical resection was performed in 91 cases (67%), and frozen section was performed in 62 patients (43 positives). Incomplete resections were in 42 cases. Patients who underwent complete surgical resection had mean survival of 14.58 months and median of 10.5 months, compared to incomplete resection patients with 9.12 months and 6.5 months respectively.
Conclusion
Our review shows complete surgical resection results in better short- and long-term outcomes in intracardiac sarcoma patients. Furthermore, combining chemo-radiotherapy has additional benefits towards long-term survival.
Abstract Recent experimental and numerical evidence has shown that the cumulative wake generated from the overlapping of multiple wakes within a wind farm could reduce power performance and enhance ...fatigue loads of wind turbines installed in neighboring downstream wind farms and may also extend up to distances one order of magnitude larger than those typically considered for intra-farm wake interactions. Similar to individual wind turbine wakes, wind farm wakes have a velocity deficit and added turbulence intensity, both affected by the turbine rotor thrust forces and the incoming turbulence intensity. Therefore, the evolution of wind farm wakes will vary for different operational and atmospheric conditions. In this paper, lidar measurements collected during the American WAKE experimeNt (AWAKEN) and wind tunnel tests of wind farms reproduced by porous disks are leveraged to investigate wind farm wakes.
Alternative splicing (AS) is the direct cause of different transcripts in eukaryotes and plays a vital role in biological processes such as plant growth and signal transduction. Reproductive ...development is the key process for rice production. Although numerous studies on AS in plants have been identified, AS of reproductive development stage between
japonica
and
indica
rice has not been conducted. In this research, we identified 6994 genes (19.2% of the total number of genes) corresponding to 14,517 AS events from the rice genome using the transcriptome data of 58 representative panicles of
japonica
rice and
indica
rice. Among the different types of AS, the frequency of exon skipping (SE) is the highest, accounting for more than 87%; the frequency of the alternative 3′ splice site (A3SS) type is about twice that of the alternative 5′ splice site (A5SS) type. GO enrichment analysis results showed that AS genes were mainly enriched in cellular and metabolic processes in the biological process classification. Moreover, 68 differentially AS events involved 56 genes. The expression of these five genes (
OscTPI
,
OsLOL1
,
RBS1
,
PTB1
and
OsPDIL1;1
) was significantly different between the two subspecies. The analysis of AS events in panicles of
japonica
and
indica
rice provide new information regarding AS occurrence and function during these two subspecies differentiation in rice domestication and provide a theoretical basis for subsequent variety improvement.
We have observed that conditioning for hematopoietic transplantation by lethal irradiation induces a proteolytic microenvironment in the bone marrow (BM) that activates the complement cascade (CC). ...As a result, BM is enriched for proteolytic enzymes and the soluble form of the terminal product of CC activation, the membrane attack complex C5b-C9 (MAC). At the same time, proteolytic enzymes induced in irradiated BM impair the chemotactic activity of α-chemokine stromal-derived factor-1 (SDF-1). As SDF-1 is considered a crucial BM chemoattractant for transplanted hematopoietic stem/progenitor cells (HSPCs), we sought to determine whether other factors that are resistant to proteolytic enzymes have a role in this process, focusing on proteolysis-resistant bioactive lipids. We found that the concentrations of sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) increase in the BM after conditioning for transplantation and that both S1P and, as we show here for the first time, C1P are potent chemoattractants for HSPCs. Next, we observed that C5-deficient mice that do not generate MAC show impaired engraftment of HSPCs. In support of a role for MAC in homing and engraftment, we found that soluble MAC enhances in a CR3 (CD11b/CD18)-dependent manner the adhesion of HSPCs to BM stromal cells and increases the secretion of SDF-1 by BM stroma. We conclude that an increase in BM levels of proteolytic enzyme-resistant S1P and C1P and activation of CC, which leads to the generation of MAC, has an important and previously underappreciated role in the homing of transplanted HSPCs.
This study proposes a stochastic optimisation model for the day-ahead scheduling in power systems, which incorporates the hourly demand response (DR) for managing the variability of renewable energy ...sources (RES). DR considers physical and operating constraints of the hourly demand for economic and reliability responses. The proposed stochastic day-ahead scheduling algorithm considers random outages of system components and forecast errors for hourly loads and RES. The Monte Carlo simulation is applied to create stochastic security-constrained unit commitment (SCUC) scenarios for the day-ahead scheduling. A general-purpose mixed-integer linear problem software is employed to solve the stochastic SCUC problem. The numerical results demonstrate the benefits of applying DR to the proposed day-ahead scheduling with variable RES.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in a variety of tumor cells by engaging the death receptors 4 (DR4) and 5 (DR5). We investigated the effect of ...chemotherapeutic drugs on DR4-mediated apoptosis in human bladder cancer cells, using a human monoclonal agonistic antibody specific for DR4, mapatumumab. Cytotoxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Synergy was assessed by isobolographic analysis. Treatment of human bladder cancer T24 cells with mapatumumab in combination with mitomycin C, vinblastine or gemcitabine did not overcome resistance to these agents. However, treatment with mapatumumab in combination with epirubicin (EPI) had a synergistic cytotoxic effect. Synergy was also obtained in KU7 and RT112 human bladder cancer cells. A synergistic effect was also observed with mapatumumab in combination with pirarubicin. The synergy obtained in cytotoxicity with mapatumumab and EPI was also achieved in apoptosis. EPI markedly increased DR4 expression in the bladder cancer cells at both the mRNA and protein levels. Furthermore, the combination-induced cytotoxicity was significantly suppressed by the DR4:Fc chimeric protein. The combination of EPI and mapatumumab significantly activated the caspase cascade, including caspase-8, -9 and -3, which are the downstream molecules of death receptors. These findings indicate that EPI sensitizes bladder cancer cells to DR4-mediated apoptosis through induction of DR4 and activation of caspases, suggesting that the combination therapy of EPI and mapatumumab may be effective for bladder cancer therapy.
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