The effects of an anti-P-selectin monoclonal antibody (MAb, PB1.3; Cytel Corporation) on neoendothelialization; neoendothelial function, as evidenced by acetylcholine-induced relaxation (nitric oxide ...formation); and intimal hyperplasia following embolectomy catheter-induced injury to the rabbit thoracic aorta were investigated. Catheter injury was induced in two groups of New Zealand White rabbits. One group received no treatment, while the second group received short-term treatment with the MAb (i.p., immediately before and 12 h after induction of catheter injury). A third group underwent a sham operation and served as uninjured controls. Following sacrifice at 2 weeks after injury, aortic rings were assessed for degree of intimal hyperplasia, neoendothelial morphology (scanning electron microscopy), and acetylcholine-induced relaxation. Aortic tissue from catheter-injured animals that received treatment exhibited improved neoendothelial morphology, as compared with tissue from untreated but catheterized animals; however, no statistically significant attenuation of the hyperplastic response or improvement in the attenuated neoendothelial-dependent acetylcholine-induced relaxant response that is characteristic of neoendothelium that forms after catheter denudation was observed. These data suggest that short-term attenuation of P-selectin-mediated polymorphonuclear leukocyte (PMN)/endothelium, PMN/platelet interactions, and/or thrombin formation beneficially affects neoendothelialization of the vascular wall following balloon catheter-induced injury.
This study applied an early screening approach to determine the risk status of children in 5 urban schools and monitor their patterns of reading growth over 3 years. A majority of students were from ...culturally diverse and low-SES backgrounds. Two validated instruments were used for determining (a) academic risk (the Dynamic Indicators of Basic Early Literacy Skills DIBELS; Good, Simmons, & Smith, 1998) and (b) behavioral risk (Systematic Screening for Behavior Disorders SSBD; Walker & Severson, 1992, or Early Screening Project; Walker, Severson, & Feil, 1995). DIBELS data for 383 students were used to determine the characteristics and effectiveness of reading curriculum reforms for students in kindergarten through 2nd grade. Results indicated that students with a single risk factor (academic or behavioral) progressed more slowly than the general population in the participating schools. The students with behavioral risks, however, made better progress, becoming more fluent readers than the students with academic risks. Students with both academic and behavioral risks made the least progress. "The Reading Mastery" curriculum (Reading Mastery, 1995) produced better growth in reading fluency than did "Success for All" (Success for All, 1999) or the literature-based curriculum. It also produced better growth for students with academic, behavioral, or both risk factors. The "Success for All" curriculum produced less growth compared to the "Reading Mastery" curriculum but was superior to the literature-based curriculum. Implications are discussed. (Contains 4 tables and 3 figures.)
Reviews: Books, Films, Music Barbre, Claude; Akers, Ann M; Hirschman, Lynne ...
Journal of religion and health,
12/1999, Letnik:
38, Številka:
4
Journal Article
PDF
