Remote monitoring of motor functions is a powerful approach for health assessment, especially among the elderly population or among subjects affected by pathologies that negatively impact their ...walking capabilities. This is further supported by the continuous development of wearable sensor devices, which are getting progressively smaller, cheaper, and more energy efficient. The external environment and mobility context have an impact on walking performance, hence one of the biggest challenges when remotely analysing gait episodes is the ability to detect the context within which those episodes occurred. The primary goal of this paper is the investigation of context detection for remote monitoring of daily motor functions. We aim to understand whether inertial signals sampled with wearable accelerometers, provide reliable information to classify gait-related activities as either indoor or outdoor. We explore two different approaches to this task: (1) using gait descriptors and features extracted from the input inertial signals sampled during walking episodes, together with classic machine learning algorithms, and (2) treating the input inertial signals as time series data and leveraging end-to-end state-of-the-art time series classifiers. We directly compare the two approaches through a set of experiments based on data collected from 9 healthy individuals. Our results indicate that the indoor/outdoor context can be successfully derived from inertial data streams. We also observe that time series classification models achieve better accuracy than any other feature-based models, while preserving efficiency and ease of use.
The urinary excretion of leucine aminopeptidase (LAP), N‐acetyl‐β‐glucosaminidase (NAG), and β2‐microglobulin was measured in 12 cancer patients receiving cis‐platinum to evaluate the sensitivity of ...these indices for renal tubular damage. NAG and LAP excretion rose markedly in all patients, and β2‐microglobutin rose in 11. Seven of the 9 patients who had received cis‐platinum 6 wk before the study had prestudy dose elevations of one or more of these indices. We conclude that these urinary proteins are sensitive indicators of proximal renal tubular injury and may provide greater sensitivity for comparison of the nephrotoxic potential of future platinum analogs or for assessing the efficacy of regimens designed to protect the kidney from platinum nephrotoxicity than other measurements. The persistence of high excretion values for these indices 6 wk after a dose demonstrates the persistent renal injury by cis‐platinum.
Clinical Pharmacology and Therapeutics (1980) 27, 557–562; doi:10.1038/clpt.1980.79
Purpose - The purpose of this paper is to provide a number of examples of how Web 2.0 technologies and approaches (Library 2.0) are being used within the library sector. The paper acknowledges that ...there are a variety of risks associated with such approaches. The paper describes the different types of risks and outlines a risk assessment and risk management approach which is being developed to minimise the dangers while allowing the benefits of Library 2.0 to be realised.Design methodology approach - The paper outlines various risks and barriers which have been identified at a series of workshops run by UKOLN (a national centre of expertise in digital information management based in the UK) for the cultural heritage sector. A risk assessment and risk management approach, which was initially developed to support use of Web 2.0 technologies at events organised by UKOLN, is described and its potential for use within the wider library community, in conjunction with related approaches for addressing areas such as accessibility and protection of young people, is described.Findings - Use of Library 2.0 approaches is becoming embedded across many libraries which seek to exploit the benefits which such technologies can provide. The need to ensure that the associated risks are identified and appropriate mechanisms implemented to minimise such risks is beginning to be appreciated.Practical implications - The areas described here should be of relevance to many library organisations which are making use of Library 2.0 services.Originality value - The paper should prove valuable to policy makers and web practitioners within libraries who may be aware of the potential benefits of Library 2.0 but have not considered the associated risks.
We conducted a search for occultations of bright stars by Kuiper Belt Objects (KBOs) to estimate the density of sub-km KBOs in the sky. We report here the first results of this occultation survey of ...the outer solar system conducted in June 2007 and June/July 2008 at the MMT Observatory using Megacam, the large MMT optical imager. We used Megacam in a novel shutterless continuous--readout mode to achieve high precision photometry at 200 Hz. We present an analysis of 220 star hours at signal-to-noise ratio of 25 or greater. The survey efficiency is greater than 10% for occultations by KBOs of diameter d>=0.7 km, and we report no detections in our dataset. We set a new 95% confidence level upper limit for the surface density \Sigma_N(d) of KBOs larger than 1 km: \Sigma_N(d>=1 km) <= 2.0e8 deg^-2, and for KBOs larger than 0.7 km \Sigma_N(d>= 0.7 km) <= 4.8e8 deg^-2.
We present preliminary results of the analysis of the first 500 squaredegrees of the Southern Edgeworth-Kuiper belt Survey, a large sky survey whichran from January 2000 to January 2003 and comprises ...2900° in total. Early testspredict that we should discover ∼10 bright TNOs in our data, doubling the currentknown population.
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