In this article, I draw on feminist and new social movement literature to analyse contemporary Mexico's Women's Collective Action (WCA) through a framework of prefiguration. I challenge traditional ...epistemological analysis of social movement theory by engaging with Icaza's (2019) body-mind-spirit framework and Ahmed's (2004) cultural politics of emotions in my analysis of the cultural outcomes of the women's movements. By analysing emotions as cultural practices rather than psychological states, we can understand the intricate and at times contradictory reciprocal emotions at the inside of the women's movements. Similarly, analysing direct action through the body-mind-spirit framework, allows for a complex reading of direct action that transverses the body/mind cartesian dichotomy, instead understanding the body as the primary territory of defence in the healing, re-imagining and (re)building process of new relationships of doing and being. By engaging with an analysis of the contemporary Mexican feminist movement, I argue the WCA in Mexico is part of a new wave of hope movements which engage in a process of prefiguration through the construction of alternative, anti-patriarchal worlds in the present. Rather than one united front with a series of political goals, the only strategy this movement embodies is its desire to build (an)other worlds.
Objective
The objective of this study was to assess the SARS‐CoV‐2–specific humoral and T cell response after a two‐dose regimen of SARS‐CoV‐2 vaccine in patients with rheumatoid arthritis (RA).
...Methods
In this observational study, patients with RA who are ≥18 years of age and vaccinated for SARS‐CoV‐2 according to the Argentine National Health Ministry's vaccination strategy were included. Anti–SARS‐CoV‐2 immunoglobulin G (IgG) antibodies (ELISA‐COVIDAR test), neutralizing activity (cytotoxicity in VERO cells), and specific T cell response (IFN‐γ ELISpot Assay) were assessed after the first and second dose.
Results
A total of 120 patients with RA were included. Mostly, homologous regimens were used, including Gam‐COVID‐Vac (27.5%), ChAdOx1 (24.2%), and BBIBP‐CorV (22.5%). The most frequent combination was Gam‐COVID‐Vac/mRNA‐1273 (21.7%). After the second dose, 81.7% presented with anti–SARS‐CoV‐2 antibodies, 70.0% presented with neutralizing activity, and 65.3% presented with specific T cell response. The use of BBIBP‐CorV and treatment with abatacept (ABA) and rituximab (RTX) were associated with undetectable antibodies and no neutralizing activity after two doses. BBIBP‐CorV was also associated with the absence of T cell response. The total incidence of adverse events was 357.1 events per 1,000 doses, significantly lower with BBIBP‐CorV (166.7 events per 1,000 doses, P < 0.02).
Conclusion
In this RA cohort vaccinated with homologous and heterologous regimens against COVID‐19, 2 out of 10 patients did not develop anti‐SARS‐CoV‐2 IgG, 70% presented with neutralizing activity, and 65% presented with specific T cell response. The use of BBIBP‐CorV was associated with deficient humoral and cellular response, whereas treatment with ABA and RTX resulted in an impaired anti‐SARS‐CoV‐2 IgG formation and neutralizing activity.
Background: Peru is one of the most biodiverse countries in the world, which is reflected in its wealth of knowledge about medicinal plants. However, there is a lack of information regarding ...intestinal absorption and the permeability of natural products. The human colon adenocarcinoma cell line (Caco-2) is an in vitro assay used to measure apparent permeability. This study aims to develop a quantitative structure–property relationship (QSPR) model using machine learning algorithms to predict the apparent permeability of the Caco-2 cell in natural products from Peru. Methods: A dataset of 1817 compounds, including experimental log Papp values and molecular descriptors, was utilized. Six QSPR models were constructed: a multiple linear regression (MLR) model, a partial least squares regression (PLS) model, a support vector machine regression (SVM) model, a random forest (RF) model, a gradient boosting machine (GBM) model, and an SVM–RF–GBM model. Results: An evaluation of the testing set revealed that the MLR and PLS models exhibited an RMSE = 0.47 and R2 = 0.63. In contrast, the SVM, RF, and GBM models showcased an RMSE = 0.39–0.40 and R2 = 0.73–0.74. Notably, the SVM–RF–GBM model demonstrated superior performance, with an RMSE = 0.38 and R2 = 0.76. The model predicted log Papp values for 502 natural products falling within the applicability domain, with 68.9% (n = 346) showing high permeability, suggesting the potential for intestinal absorption. Additionally, we categorized the natural products into six metabolic pathways and assessed their drug-likeness. Conclusions: Our results provide insights into the potential intestinal absorption of natural products in Peru, thus facilitating drug development and pharmaceutical discovery efforts.
Nanoemulgels are novel formulations of great interest for their use as dual-release systems and as fat substitutes in foods. Lemon essential oil, with a large number of benefits due to its ...antimicrobial, antifungal, and medicinal properties, and low methoxyl pectin, a natural polysaccharide capable of gelling by adding divalent ions such as calcium, are very appropriate ingredients to produce nanoemulgels with potential applications in industries such as cosmetics, agrochemistry, pharmaceuticals, or food. In this work, lemon-essential-oil-in-water nanoemulgels containing low methoxyl pectin derived from citrus peels were prepared following a three-step process that involves the preparation of a nanoemulsion, a pectin gel, and the mixture of both. In the first stage, the stirring time and the rotational rate employed during the mixing step were assessed. Once the preparation protocol was established, the pectin gel/nanoemulsion mass ratio was investigated. Different techniques were combined to evaluate the influence of the processing and the composition variables on the particle size distribution, mean diameters, flow curves, and physical stability of different emulgels obtained. It was found that the processing variables studied, stirring time, and rotational rate, do not influence the mean particle size of the emulgel, with values matching those of the starting nanoemulsion. However, 3 min and 200 rpm were selected for exhibiting the lowest TSI values. Regarding the composition, a higher content of pectin gel caused a higher viscosity, and therefore a higher physical stability, with the 75P/25E emulgel being the most stable. Aggregation of gel particles, because the pectin gel was really a sheared gel, was the main responsible contributor to the results obtained. This work highlights the importance of the preparation and formulation variables to develop stable, innovative formulations based on nanoemulgels.
An emulgel-based delivery system formulated with sweet fennel essential oil was developed for the encapsulation of β-carotene. Emulgels were stabilized by using a mixed emulsifier system consisting ...of fumed silica particles (Aerosil 200) and a green surfactant (Amidet-N). The influence of the microfluidization conditions on mean droplet sizes and the effect of the fumed silica concentration on the physical stability and rheological properties of emulgels were investigated. The emulgel that presented better physical stability was that formulated with 5 g/100 g fumed silica due to the role of Aerosil 200 as Pickering stabilizer and its enhanced rheological properties. The resulting β-carotene-loaded emulgels successfully protected the encapsulated bioactive ingredient throughout the storage period.
•Stable sweet fennel oil emulgels delivery systems were formulated.•Emulgels in the nanometer scale were developed by microfluidization technique.•A fumed silica improved the emulgels physical stability and rheological properties.•Aerosil 200 is utilized as a thickening agent and Pickering stabilizer.•A β-carotene encapsulation efficiency of 88.3% was obtained.
State-of-the-art Optical Music Recognition (OMR) techniques follow an end-to-end or holistic approach, i.e., a sole stage for completely processing a single-staff section image and for retrieving the ...symbols that appear therein. Such recognition systems are characterized by not requiring an exact alignment between each staff and their corresponding labels, hence facilitating the creation and retrieval of labeled corpora. Most commonly, these approaches consider an agnostic music representation, which characterizes music symbols by their shape and height (vertical position in the staff). However, this double nature is ignored since, in the learning process, these two features are treated as a single symbol. This work aims to exploit this trademark that differentiates music notation from other similar domains, such as text, by introducing a novel end-to-end approach to solve the OMR task at a staff-line level. We consider two Convolutional Recurrent Neural Network (CRNN) schemes trained to simultaneously extract the shape and height information and to propose different policies for eventually merging them at the actual neural level. The results obtained for two corpora of monophonic early music manuscripts prove that our proposal significantly decreases the recognition error in figures ranging between 14.4% and 25.6% in the best-case scenarios when compared to the baseline considered.
In the search for solution-processable TADF materials as a light emitting layer for OLED devices, polymers have attracted considerable attention due to their better thermal and morphological ...properties in the film state with respect to small molecules. In this work, a new polymer (
-TPS-DMAC-TRZ) with thermally activated delayed fluorescence (TADF) light-emitting characteristics was prepared from a conjugation-break unit (TPS) and a well-known TADF core (DAMC-TRZ). This material was designed to preserve the photophysical properties of DAMC-TRZ, while improving other properties, such as thermal stability, promoted by its polymerization with a TPS core. Along with excellent solubility in common organic solvents such as toluene, chloroform and THF, the polymer (M
= 9500; M
= 15200) showed high thermal stability (TDT
= 481 °C), and a T
value of 265 °C, parameters higher than the reference small molecule DMAC-TRZ (TDT
= 305 °C; T
= 91 °C). The photoluminescence maximum of the polymer was centered at 508 nm in the solid state, showing a low redshift compared to DMAC-TRZ (500 nm), while also showing a redshift in solution with solvents of increasing polarity. Time-resolved photoluminescence of
-TPS-DMAC-TRZ at 298 K, showed considerable delayed emission in solid state, with two relatively long lifetimes, 0.290 s (0.14) and 2.06 s (0.50), and a short lifetime of 23.6 ns, while at 77 K, the delayed emission was considerably quenched, and two lifetimes in total were observed, 24.6 ns (0.80) and 180 ns (0.20), which was expected from the slower RISC process at lower temperatures, decreasing the efficiency of the delayed emission and demonstrating that
-TPS-DMAC-TRZ has a TADF emission. This is in agreement with room temperature TRPL measurements in solution, where a decrease in both lifetime and delayed contribution to total photoluminescence was observed when oxygen was present. The PLQY of the mCP blend films with 1%
-TPS-DMAC-DMAC-TRZ as a dopant was determined to be equal to 0.62, while in the pure film, it was equal to 0.29, which is lower than that observed for DMAC-TRZ (0.81). Cyclic voltammetry experiments showed similarities between
-TPS-DMAC-TRZ and DAMC-TRZ with HOMO and LUMO energies of -5.14 eV and -2.76 eV, respectively, establishing an electrochemical bandgap value of 2.38 eV. The thin film morphology of
-TPS-DMAC-TRZ and DMAC-TRZ was compared by AFM and FE-SEM, and the results showed that p-TPS-DMAC-TRZ has a smoother surface with fewer defects, such as aggregations. These results show that the design strategy succeeded in improving the thermal and morphological properties in the polymeric material compared to the reference small molecule, while the photophysical properties were mostly maintained, except for the PLQY determined in the pure films. Still, these results show that p-TPS-DMAC-TRZ is a good candidate for use as a light-emitting layer in OLED devices, especially when used as a host-guest mixture in suitable materials such as mCP.
The current national influenza vaccination schedule in Mexico does not recommend vaccination in the school-aged population (5-11 years). Currently, there are limited data from middle-income countries ...analysing the cost-effectiveness of influenza vaccination in this population. We explored the clinical effects and economic benefits of expanding the current national influenza vaccination schedule in Mexico to include the school-aged population.
A static 1-year model incorporating herd effect was used to assess the cost-effectiveness of expanding the current national influenza vaccination schedule of Mexico to include the school-aged population. We performed a cross-sectional epidemiological study using influenza records (2009-2018), death records (2010-2015), and discharge and hospitalisation records (2010-2016), from the databases of Mexico's Influenza Surveillance System (SISVEFLU), the National Mortality Epidemiological and Statistical System (SEED), and the Automated Hospital Discharge System (SAEH), respectively. Cost estimates for influenza cases were based on 7 scenarios using data analysed from SISVEFLU; assumptions for clinical management of cases were defined according to Mexico's national clinical guidelines. The primary health outcome for this study was the number of influenza cases avoided. A sensitivity analysis was performed using conservative and optimistic parameters (vaccination coverage: 30% / 70%, Vaccine effectiveness: 19% / 68%).
It was estimated that expanding the influenza immunisation programme to cover school-aged population in Mexico over the 2018-2019 influenza season would result in 671,461 cases of influenza avoided (50% coverage and 50% effectiveness assumed). Associated with this were 262,800 fewer outpatient consultations; 154,100 fewer emergency room consultations; 97,600 fewer hospitalisations, and 15 fewer deaths. Analysis of cases avoided by age-group showed that 55.4% of them were in the school-aged population, and the decrease in outpatient consultations was largest in this population. There was an overall decrease in the economic burden for the Mexican health care system of 111.9 million US dollars; the immunization programme was determined to be cost-saving in the base, conservative and optimistic scenarios.
Vaccinating school-aged population in Mexico would be cost-effective; expansion of the current national vaccination schedule to this age group is supported.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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