U članku se nastoji predstaviti predmetna obrada djela područja filmske umjetnosti i kinematografije u praksi Nacionalne i sveučilišne knjižnice (NSK), te različiti problemi i nedoumice u obradi ove ...građe. Navode se opće značajke i struktura sustava predmetnog označivanja, razlozi i argumentacija za pojedina izabrana rješenja, usklađivanje s općim usvojenim načelima sadržajne obrade u sadašnjoj praksi knjižnice. Premda svaki knjižnični predmetni sustav mora imati pravila koja vrijede za sva područja, discipline i struke, pokazuju se nastojanja da se ne zanemare i određene specifične značajke sadržaja ovoga područja. Osobit naglasak stavljen je na problematiku filmološkoga nazivlja i odabir nazivlja u strukturiranju predmetnih odrednica. Komparativno se prikazuju neka od rješenja NSK predmetnog sustava (NSKPS) i Predmetnog sustava Kongresne knjižnice Library of Congress Subject Headings (LCSH).
U članku se objašnjavaju osnovna načela i praktična rješenja klasifikacije filozofije u sustavu Univerzalne decimalne klasifikacije (UDK) u Nacionalnoj i sveučilišnoj knjižnici u Zagrebu. U ...sadržajnoj obradi filozofske literature možemo razlikovati nekoliko skupina: izvorna filozofska djela, studije, kritike i interpretacije pojedinih filozofa ili filozofskih sustava, povijest filozofije te referentnu filozofsku građu. Klasifikacijska shema filozofije prema UDK razvrstava građu u tri osnovne skupine: priroda filozofije i filozofiranja, filozofske discipline, filozofski sustavi i gledišta. Po nekim karakteristikama koje proizlaze iz same prirode filozofskog mišljenja, kao specifičnoga intelektualnog fenomena zapadne civilizacije, skupina filozofije razlikuje se od skupina svih drugih znanstvenih područja i disciplina. Mnoge od tih znanosti nastaju u okrilju filozofije, što i u suvremenosti uvjetuje specifičan odnos među njima. Ističe se potreba dosljednog okupljanja filozofskih djela u skladu s njihovim predmetom i oblikom kako bi se osiguralo njihovo pronalaženje i uporaba.
U članku su prikazani načini i osnovna načela klasifikacije dijela građe iz područja psihologije i psihijatrije, unutar sheme Univerzalne decimalne klasifikacije. U Nacionalnoj i sveučilišnoj ...knjižnici u Zagrebu dio se takve građe pri klasificiranju svrstava u samo jednu skupinu, psihologiju ili psihijatriju, ali je česta praksa svrstavanja u obje skupine, i dodjeljivanja dviju, pa i više UDK oznaka jednom dokumentu. O prvoj UDK oznaci, s obzirom na sadržaj jedinice te znanstveni i metodološki pristup autora pojedinoj temi, prosuđuje klasifikator.
Spontaneous coronary artery dissection (SCAD) was underdiagnosed and poorly understood for decades. It is increasingly recognized as an important cause of myocardial infarction (MI) in women. We ...aimed to assess the natural history of SCAD, which has not been adequately explored.
We performed a multicentre, prospective, observational study of patients with non-atherosclerotic SCAD presenting acutely from 22 centres in North America. Institutional ethics approval and patient consents were obtained. We recorded baseline demographics, in-hospital characteristics, precipitating/predisposing conditions, angiographic features (assessed by core laboratory), in-hospital major adverse events (MAE), and 30-day major adverse cardiovascular events (MACE). We prospectively enrolled 750 SCAD patients from June 2014 to June 2018. Mean age was 51.8 ± 10.2 years, 88.5% were women (55.0% postmenopausal), 87.7% were Caucasian, and 33.9% had no cardiac risk factors. Emotional stress was reported in 50.3%, and physical stress in 28.9% (9.8% lifting >50 pounds). Predisposing conditions included fibromuscular dysplasia 31.1% (45.2% had no/incomplete screening), systemic inflammatory diseases 4.7%, peripartum 4.5%, and connective tissue disorders 3.6%. Most were treated conservatively (84.3%), but 14.1% underwent percutaneous coronary intervention and 0.7% coronary artery bypass surgery. In-hospital composite MAE was 8.8%; peripartum SCAD patients had higher in-hospital MAE (20.6% vs. 8.2%, P = 0.023). Overall 30-day MACE was 8.8%. Peripartum SCAD and connective tissue disease were independent predictors of 30-day MACE.
Spontaneous coronary artery dissection predominantly affects women and presents with MI. Despite majority of patients being treated conservatively, survival was good. However, significant cardiovascular complications occurred within 30 days. Long-term follow-up and further investigations on management are warranted.
Chronic obstructive pulmonary disease (COPD) is a complex condition, whose diagnosis requires spirometric assessment. However, considering its heterogeneity, subjects with similar spirometric ...parameters do not necessarily have the same functional status. To overcome this limitation novel biomarkers for COPD have been investigated. Therefore, we aimed to explore the potential value of N-glycans as COPD biomarkers and to examine the individual variation of plasma protein and immunoglobulin G (IgG) glycosylation profiles in subjects with COPD and healthy controls.
Both the total plasma protein and IgG N-glycome have been profiled in the total of 137 patients with COPD and 95 matching controls from Croatia. Replication cohort consisted of 61 subjects with COPD and 148 controls recruited at another Croatian medical centre.
Plasma protein N-glycome in COPD subjects exhibited significant decrease in low branched and conversely, an increase in more complex glycan structures (tetragalactosylated, trisialylated, tetrasialylated and antennary fucosylated glycoforms). We also observed a significant decline in plasma monogalactosylated species, and the same change replicated in IgG glycome. N-glycans also showed value in distinguishing subjects in different COPD GOLD stages, where the relative abundance of more complex glycan structures increased as the disease progressed. Glycans also showed statistically significant associations with the frequency of exacerbations and demonstrated to be affected by smoking, which is the major risk factor for COPD development.
This study showed that complexity of glycans associates with COPD, mirroring also the disease severity. Moreover, changes in N-glycome associate with exacerbation frequency and are affected by smoking. In general, this study provided new insights into plasma protein and IgG N-glycome changes occurring in COPD and pointed out potential novel markers of the disease progression and severity.
Hematodinium is a parasitic dinoflagellate and emerging pathogen of crustaceans. It preferably manifests in haemolymph of marine decapod crustaceans, killing a large variety of genera with ...significant impacts on fisheries worldwide. There is, however, evidence that some crustacean stocks harbor high prevalence, low intensity infections that may not result in widespread host mortality and are therefore hard to detect. The most widely used methods for detection of Hematodinium are conventional blood smears and polymerase chain reaction (PCR) against ribosomal RNAs. Blood smears demand a trained investigator, are labor intensive and not readily scalable for high-throughput sampling. PCRs only detect parasite DNA and can also suffer from false negatives and positives. In order to develop alternative detection tools for Hematodinium cells in decapod crustaceans we employed an immunological approach against a newly identified, abundant dinoflagellate-specific nuclear protein--Dinoflagellate/Viral NucleoProtein (DVNP). Both immunofluorescence assay (IFA) and Western blot methods against DVNP showed high sensitivity of detection. The Western blot detects Hematodinium parasites to levels of 25 parasites per milliliter of crustacean haemolymph, with the potential for sample pooling and screening of large samples. Using both PCR and these new tools, we have identified Hematodinium cells present in three new host crab taxa, at high prevalence but with no sign of pathogenesis. This extends the known range of Hematodinium to southern Australia.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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