The antigenic phenotype of cartilage and synovial cells from six cases of primary synovial chondromatosis (PSC) was determined. This was compared with profiles similarly obtained for adult and fetal ...cartilage cells. The Ki-67 (proliferation-associated) antigen was present on 40-50 per cent of chondrocytes in the proliferative zone of fetal epiphyseal cartilage but absent in chondrocytes of adult articular cartilage and PSC cartilage nodules. The absence of Ki-67 antigen suggests that there were no proliferating cells in the synovium or cartilage in these cases of PSC. In PSC alone, some chondrocytes in the cartilage nodules and mononuclear subintimal cells around the nodules also reacted for CD68, suggesting that growth of the cartilage nodules may occur by a metaplastic process. All synoviocytes in PSC were positive for leucocyte common antigen, HLA-DR, and CD68, a pattern typical of reactive rather than normal synovium.
Adam9, Adam15 and
Adam21, genes encoding members of the ADAM or MDC family of metalloproteases, have been mapped to mouse chromosomes 8, 1, and 12, respectively, using an interspecific cross. The ...mapping of these mouse loci and the extrapolated loci for their human orthologs may facilitate the mapping of diseases involving these genes.
The membrane-type matrix metalloproteinases (MT-MMPs) constitute a newly discovered family of four enzymes within the matrix metalloproteinase (MMP) superfamily. We have mapped the genes for MT1-MMP ...(MMP14), MT2-MMP (MMP15), and MT3-MMP (MMP16) usingin situhybridization to human metaphase chromosomes. In contrast to the genes for many MMPs that are clustered on chromosome 11, the genes MMP14, MMP15, and MMP16 all map to distinct chromosomes. MMP14 maps to human chromosome 14, MMP15 to human chromosome 16, and MMP16 to human chromosome 8.
PDF
