We performed caries treatment of 10 deciduous anterior teeth with class V carious cavity using CarisolvTMth at can remove dentine caries infected with bacteria related dental caries, the ...questionnaire investigation and their prognosis. The removals of the infected dentine was confirmed by a culture test of the bacteria at each step before, during and after applying CarisolvTM. The results were obtained as follows. 1. Before CarisolvTMw as applied, bacteria related dental caries was found in 10 teeth of all subjects with the average 6.1×105 CFU at the surface and the average 1.5×105 CFU at subsurface of the caries dentine, respectively. 2. When CarisolvTM was applied, bacteria related dental caries were found in 7 out of 10 teeth with an average 6.4×104 CFU at the surface and in 8 out of 10 teeth with an average 7.7×103 CFU at the subsurface of the caries dentine, respectively. 3. After CarisolvTM was applied, the bacteria related dental caries were found in 4 out of 10 teeth with the average 1.3×102 CFU at the surface showing decrease rate of 99.989% and of 5 out of 10 teeth with an average 1.4×10 CFU at subsurface of the caries dentine, showing a decreased rate of 99.989% and 99.995%, respectively. 4. We gave some questionnaire counseling caries treatment by CarisolvTMto the patients, and all of the subjects liked this method better than conventional methods such as the air turbine and engine instruments including local anesthesia. 5. Clinical prognosis at an average of 329 days was a fine based on no spontaneous and evoked pain, no gingival swelling and no pathologic findings by inspection and radiograph in all 10 treated by CarisolvTM. From above results, CarisolvTMap plication to caries treatment at anterior primary teeth was available.
To evaluate the usefulness of new hydroxyapatite (HAP) as a pulp capping agent, comparisons with a calcium hydroxide agent (calvital®) and formocresol, which are generally used for pulpotomy, were ...performed. Serial changes in pH in these materials were investigated. Furthermore, after pulpotomy in rat molars using each material, the degree of the formation of dentine-like hard tissue and inflammatory changes in the pulp tissue were micro CT radiographically and patho-histologically examined. It has been reported that calvital® was a strong alkali (≥pH 12) causes a high level of pulp irritation, which were same as our result. The new sintered hydroxyapatite was almost neutral in pH, with a low level of pulp irritation. Furthermore, as a result of micro CT radiographical and histopathological evaluation, dentin-like hard tissue formation underneath the sectioned pulp surface was most marked in the calvital® group, and no dentin-like hard tissue formation underneath the sectioned pulp surface was noted in the HAP group. However, the HAP group developed no necrotic layers, and inflammation improved at an earlier stage. Our experiments suggested that HAP can be a good pulp capping agent, since pulp irritation was lower with HAP than with calvital® and formocresol.
We treated a crown malformation of the lower left permanent central incisor teeth in a girl aged 10 years 8 months. The malformation derived from traumatic injuries to a primary tooth at 2 years old. ...We determined the treatment plan using 3DXTM. The crown of the lower left permanent central incisor tooth had bent at 90 degrees against the root. The labial enamel entered to the dentin of the crown, and part of the enamel reached to near the pulp. We treated the tooth using indirect capping with calcium hydroxide paste for four times at intervals of two months to induce reparative dentin formation. The occlusion and esthetic appearance were adjusted by composite resin restoration. 3DXTM was useful for diagnosis and treatment of a tooth with crown malformation derived from traumatic injuries.
Abstract Background. Antibodies to thyroid-stimulating hormone (TSH) receptors that stimulate the thyroid gland cause hyperthyroidism in patients with Graves' disease, and their production during ...antithyroid drug treatment is an important determinant of the course of the disease. One factor that might contribute to the persistent production of antibodies to TSH receptors is stimulation of the release of thyroid antigens by TSH during antithyroid drug therapy. We therefore studied the effect of the suppression of TSH secretion by thyroxine on the levels of antibodies to TSH receptors after thyroid hormone secretion had been normalized by methimazole. Methods and Results. The levels of antibodies to TSH receptors were measured during treatment with methimazole, either alone or in combination with thyroxine, in 109 patients with hyperthyroidism due to Graves' disease. The patients first received 30 mg of methimazole daily for six months. All were euthyroid after six months, and their mean (±SD) level of antibodies to TSH receptors decreased from 64±9 percent to 25±15 percent (P<0.01; normal, 2.9±1.4 percent). Sixty patients then received 100 μg of thyroxine and 10 mg of methimazole and 49 received placebo and 10 mg of methimazole daily for one year. In the thyroxine-treated group, the mean serum thyroxine concentration increased from 108±16 nmol per liter to 145±11 nmol per liter (P<0.01), and the level of antibodies to TSH receptors decreased from 28±10 percent to 10±3 percent after one month of combination therapy. In the patients who received placebo and methimazole, the mean serum thyroxine concentration decreased and the level of antibodies to TSH receptors did not change. Methimazole, but not thyroxine or placebo, was discontinued in each group 1 1/2 years after the beginning of treatment. The level of antibodies to TSH receptors further decreased (from 6.6±3.2 percent at the time methimazole was discontinued to 2.1±1.2 percent one year later) in the patients who continued to receive thyroxine, but it increased (from 9.1±4.8 percent to 17.3±5.8 percent during the same period) in the patients who received placebo. One patient in the thyroxine-treated group (1.7 percent) and 17 patients in the placebo group (34.7 percent) had recurrences of hyperthyroidism within three years after the discontinuation of methimazole. Conclusions. The administration of thyroxine during antithyroid drug treatment decreases both the production of antibodies to TSH receptors and the frequency of recurrence of hyperthyroidism. (N Engl J Med 1991; 324: 947-53.)
To the Editor:
I was surprised that no reference was made in the paper by Hashizume et al.
1
(April 4 issue) to the size of the thyroid glands in the two groups of patients randomly given 100 μg of ...thyroxine or placebo. Among patients with Graves' hyperthyroidism treated with an antithyroid drug, the rate of recurrence of hyperthyroidism ranges from 25 to 75 percent.
2
A small goiter at the start of therapy has been widely considered to be a favorable prognostic indicator of remission. Furthermore, a considerable decrease in the size of the goiter during treatment has also been considered . . .
A container ship suffered serious structural damage in her fore body due to slamming in heavy seas in the North Pacific Ocean in January, 1977. She was in the fully laden condition and voyaged to ...Kobe from Oakland, California, U. S. A. A long brittle crack propagated in the fore and aft direction in shell plating of the flare part on the starbord side. The inner structures, such as longitudinals, web frames and side stringers, on the side shell of the same side were collapsed, and deck and shell plating on the port side was buckled. Furthermore, No. 2 Hatch was distorted in a parallelepiped. In the present paper, the damages are investigated from the view point of ship hydroelasticity with the aid of fracture mechanics. The results obtained suggest the importance of ship handling as well as structural design for preventing serious damages in large container ships.
PDF
