Taking a temporal perspective, we examined how employees' mood (i.e., wakefulness‐tiredness, calmness‐tenseness, and pleasantness‐unpleasantness) develops during the workday and tested employees' ...daily recovery from work as a predictor of these mood trajectories. Specifically, we analysed a serial mediation model with evening recovery experiences (i.e., psychological detachment, relaxation, mastery experiences, and control) being indirectly related to the development of next‐day mood (i.e., linear slopes) via sleep quality and start‐of‐work mood. We collected data from 124 employees who completed up to 5 daily surveys over two workweeks. Multilevel growth curve models showed that, in general, wakefulness followed a negative quadratic, calmness a positive quadratic, and pleasantness no systematic trajectory during the workday. At the day level, path analyses showed that psychological detachment indirectly and relaxation directly predicted the three start‐of‐work mood states. Moreover, mastery experiences and control directly predicted start‐of‐work calmness. Additionally, psychological detachment and relaxation indirectly predicted the development of wakefulness and psychological detachment, relaxation, and mastery experiences indirectly predicted the development of calmness. Results suggest that some benefits of daily psychological detachment, relaxation (i.e., high start‐of‐work wakefulness and calmness), and mastery experiences (i.e., high start‐of‐work calmness) tend to subside during the workday.
Focusing on the definition of recovery as a process, we examined how the four core recovery experiences (i.e., psychological detachment, relaxation, control, and mastery) develop during the evening. ...We tested whether the specific developments of recovery experiences are important for next-day favorable mood states-beyond the mean levels of recovery experiences. We collected data from 92 employees who completed daily morning and afternoon surveys over 10 workdays. In the morning surveys, we implemented the day-reconstruction method to assess detailed information about employees' recovery experiences during several episodes of the previous evening. Our final data set included 477 morning surveys with a total of 1,998 episodes and 383 afternoon surveys. Multilevel growth curve analyses showed that, in general, psychological detachment, relaxation, and control follow a positive linear trend and mastery a negative quadratic trend during the evening. Moreover, path analyses showed that the day-level increase of psychological detachment is important for next-day mood. Specifically, we found that after evenings during which employees experienced a higher increase in psychological detachment than they usually did, they had higher favorable mood states in the subsequent afternoon. Further, our results did not support associations between day-level slopes of relaxation, control, and mastery as well as next-day mood. Hence, our study demonstrates that recovery experiences systematically change during an evening and that this change is partially relevant for next-afternoon mood.
Algorithms have risen to become one, if not the central technology for producing, circulating, and evaluating knowledge in multiple societal arenas. In this book, scholars from the social sciences, ...humanities, and computer science argue that this shift has, and will continue to have, profound implications for how knowledge is produced and what and whose knowledge is valued and deemed valid. To attend to this fundamental change, the authors propose the concept of algorithmic regimes and demonstrate how they transform the epistemological, methodological, and political foundations of knowledge production, sensemaking, and decision-making in contemporary societies. Across sixteen chapters, the volume offers a diverse collection of contributions along three perspectives on algorithmic regimes: the methods necessary to research and design algorithmic regimes, the ways in which algorithmic regimes reconfigure sociotechnical interactions, and the politics engrained in algorithmic regimes.
Eating healthily in terms of fruit and vegetable consumption has beneficial effects for employees and their organisations. Yet, we know little about how employees' eating behaviour develops over ...longer periods of time (trajectories) as well as about how subgroups of employees in these trajectories differ (trajectory classes). Gaining such insights is critical to understand how employees address healthy eating recommendations over time as well as to develop individualised interventions that also consider the development of healthy eating (i.e. improvement versus impairment beyond mean levels). We analysed panel data (Longitudinal Internet Studies for the Social Sciences) from 1054 employees by means of growth mixture modelling. Our analyses revealed three relevant classes of healthy‐eating trajectories: a favourable trajectory class, an unfavourable trajectory class and a strongly improving trajectory class. Furthermore, unfavourable healthy‐eating trajectories were especially critical with respect to impaired psychological well‐being. Specifically, we found robust results for impaired positive and negative affects, but not for self‐esteem, in the unfavourable trajectory class. We discuss limitations and implications of these findings, thereby encouraging research and practice to further consider such fine‐grained approaches (i.e. focusing on subgroups within a larger population) when addressing healthy‐eating promotion over time.
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing-remitting disease course at early stages, distinct lesion characteristics in cortical grey versus subcortical white matter and ...neurodegeneration at chronic stages. Here we used single-nucleus RNA sequencing to assess changes in expression in multiple cell lineages in MS lesions and validated the results using multiplex in situ hybridization. We found selective vulnerability and loss of excitatory CUX2-expressing projection neurons in upper-cortical layers underlying meningeal inflammation; such MS neuron populations exhibited upregulation of stress pathway genes and long non-coding RNAs. Signatures of stressed oligodendrocytes, reactive astrocytes and activated microglia mapped most strongly to the rim of MS plaques. Notably, single-nucleus RNA sequencing identified phagocytosing microglia and/or macrophages by their ingestion and perinuclear import of myelin transcripts, confirmed by functional mouse and human culture assays. Our findings indicate lineage- and region-specific transcriptomic changes associated with selective cortical neuron damage and glial activation contributing to progression of MS lesions.
Adjuvant chemotherapy for colon cancer (UICC stage II and III) has been under investigation over the last 30 years, regarding treatment duration and regimens. In this review, choice of regimen, its ...duration, possible limitations and future perspectives are discussed. Monotherapy with 5-fluorouracil was followed by addition of oxaliplatin, resulting in improved 3-yr disease free survival (DFS) and overall survival (OS) rates, but also increased peripheral sensory neurotoxicity (PSN). The International Duration Evaluation of Adjuvant therapy (IDEA) collaboration demonstrated less toxicity, especially PSN, when shortening treatment duration to 3 months. However, formally, the anticipated non-inferiority of 3 months with fluoropyrimidine (FP)/oxaliplatin over 6 months (at 3-yr DFS) was not met for all patients groups, although subgroup analyses showed non-inferiority with capecitabine/oxaliplatin (CAPOX) rather than with FOLFOX, and also in relation to the prognostic information (e.g., clinical low-risk group, pT1-3 N0). In addition, first data of newer parameters like Immunoscore
and ctDNA show promising results as stratification parameters. Further investigations to better define clinical risk groups and prognostic factors are mandatory. Besides this, individual decision-making of treatment intensity (FP or FP/oxaliplatin) and duration should always consider patient characteristics and preferences, also given the absolute relatively small differences and their clinical relevance.
PDF
