Glucagon family of peptide hormones is a group of structurally related brain-gut peptides that exert their pleiotropic actions through interactions with unique members of class B1 G protein-coupled ...receptors (GPCRs). They are key regulators of hormonal homeostasis and are important drug targets for metabolic disorders such as type-2 diabetes mellitus (T2DM), obesity, and dysregulations of the nervous systems such as migraine, anxiety, depression, neurodegeneration, psychiatric disorders, and cardiovascular diseases. The current review aims to provide a detailed overview of the current understanding of the pharmacological actions and therapeutic advances of three members within this family including glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon.
In this present work, it is envisaged to enhance seed germination using Mo doped WO
3
nanoparticles. Mo as a micro nutrient plays a vital role in germination and growth in plant biology. The pristine ...and Mo doped WO
3
(Mo:WO
3
) nanoparticles are synthesized using acid assisted precipitation technique. Both pristine and doped samples were characterized by XRD, SEM/EDS, FTIR, Raman, UV-DRS, PL and XPS spectral techniques. The XRD pattern corroborates the monoclinic phase of synthesised products. The SEM and EDS analysis shows effective doping of Mo into host lattices of WO
3
. The structural aspects were confirmed using FTIR and Raman spectral studies. The doping of Mo lead to a decrease in band gap energy assisted with increase in Urbach energy. The defect states in energy levels were studied using PL analysis and the chemical composition using XPS. The WO
3
nanoparticles show robust antibacterial activities against the
Pseudomonas aeruginosa
and
Xanthomonas oryzae pv
bacterial strains. The seed germination properties on kodo millet seeds were evaluated showing a more pronounced effect for Mo doped than pristine WO
3
nanoparticles. Hence this material can be used in such a way that the dopant Mo aids in seed germination while WO
3
acts as a good antibacterial agent that retards plant growth.
The nuclei below lead but with more than 126 neutrons are crucial to an understanding of the astrophysical r process in producing nuclei heavier than A∼190. Despite their importance, the structure ...and properties of these nuclei remain experimentally untested as they are difficult to produce in nuclear reactions with stable beams. In a first exploration of the shell structure of this region, neutron excitations in ^{207}Hg have been probed using the neutron-adding (d,p) reaction in inverse kinematics. The radioactive beam of ^{206}Hg was delivered to the new ISOLDE Solenoidal Spectrometer at an energy above the Coulomb barrier. The spectroscopy of ^{207}Hg marks a first step in improving our understanding of the relevant structural properties of nuclei involved in a key part of the path of the r process.
Interference in Wireless Sensor Network (WSN) predominantly affects the performance of the WSN. Energy consumption in WSN is one of the greatest concerns in the current generation. This work presents ...an approach for interference measurement and interference mitigation in point to point network. The nodes are distributed in the network and interference is measured by grouping the nodes in the region of a specific diameter. Hence this approach is scalable and isextended to large scale WSN. Interference is measured in two stages. In the first stage, interference is overcome by allocating time slots to the node stations in Time Division Multiple Access (TDMA) fashion. The node area is split into larger regions and smaller regions. The time slots are allocated to smaller regions in TDMA fashion. A TDMA based time slot allocation algorithm is proposed in this paper to enable reuse of timeslots with minimal interference between smaller regions. In the second stage, the network density and control parameter is introduced to reduce interference in a minor level within smaller node regions. The algorithm issimulated and the system is tested with varying control parameter. The node-level interference and the energy dissipation at nodes are captured by varying the node density of the network. The results indicate that the proposed approach measures the interference and mitigates with minimal energy consumption at nodes and with less overhead transmission.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
The ACtive TARget and Time Projection Chamber (ACTAR TPC) is a novel gas-filled detector that has recently been constructed at GANIL. This versatile detector is a gaseous thick target that allows the ...tracking of charged particles in three dimensions and provides a precise reaction energy reconstruction from the vertex position. A commissioning experiment using resonant scattering of a 3.2MeV/nucleon 18O beam on an isobutane gas (proton) target was performed. The beam and the heavy scattered ions were stopped in the gas volume, while the light recoil left the active volume and were stopped in auxiliary silicon detectors. A dedicated tracking algorithm was applied to determine the angle of emission and the length of the trajectory of the ions, to reconstruct the reaction kinematics used to built the excitation functions of the 1H(18O, 18O)1H and 1H(18O, 15N)4He reactions. In this article, we describe the design of the detector and the data analysis, that resulted in center of mass reaction energy resolutions of 38(4)keV FWHM and 54(9)keV FWHM for the proton and alpha channels, respectively.
The presence of a neutron halo in 15C has been demonstrated in several reaction experiments at intermediate energies. In the present study, the dynamical effects of this structure are observed for ...the first time at Coulomb barrier energies in the 15C + 208Pb quasi-elastic scattering at Elab=65 MeV, measured at the HIE-ISOLDE facility, CERN using the high-granularity detector array GLORIA. A combined continuum discretised coupled channels and coupled reaction channels calculation describes the data well and significant coupling effects due both to breakup and single-neutron stripping are identified.
The Solar Air Heater (SAH) has one of the important application of solar heating collectors, due to the air heater requires less material than others. It may be used for space heating and drying. Our ...aim of this project is to enhance the efficiency of flat plate SAH. By increasing the heat transfer rate of the collector, the efficiency is also increased. The heat transferring rate can be enhanced by increasing the area of the collector. Extended surfaces or fins can be used to increase the heat transferring rate as well as the efficiency of SAH. In this article, the cylindrical fins are used to increase the efficiency of SAH. To compare efficiencies of flat plate collectors with and without fins. The performance of the collector has been found using two methods of prediction such as theoretical and computational methods.
The energy loss profiles of different ion beams (6Li, 27Al and 50Ti) impinging on CF4, isobutane and P10 have been measured with the active target ACTAR TPC demonstrator. The pressure of the gas, ...monitored during the experiment, has been chosen in order to stop the ions inside the active zone. Starting from the energy loss calculation produced by the SRIM code, the experimental ion tracks have been simulated, taking into account the effect of the thermal diffusion of electrons during their drift towards the pad plane under the effect of a uniform electric field. The uncertainty in the geometry, mainly due to the thickness and deformation of the mylar interface window between the gas volume and the high vacuum line, has been taken into account. A good agreement is obtained between the experimental and simulated energy loss profiles.
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