Wireless Sensor Networks (WSN) is in large use in today’s world against the challenges encountered in the Sensor world. Energy consumption, routing, interference mitigation are a matter of concern in ...WSN. Perhaps, overruling interference mitigation would solve a number of interconnected problems in WSN. The proposed work is narrowed down to minimize interference in distributed homogenous WSN, ensuring that all the nodes in the network operate with the same transmission power. In this paper, an optimal shortest distance algorithm, Dynamic-Optimal Shortest Path Algorithm (DOSPA) is proposed to identify the shortest path in communication between point to point nodes. As the data traverses a number of intermediary nodes, a privileged network topology has to be built to ensure proper transmission of data. An ideal network topology is hence built dynamically for data transmission. However, a collision between data packets in interconnecting nodes is likely to occur. Furthermore, to minimize collision a non-persistent round-robin CSMA/CD algorithm is proposed. We study the network throughput, packet delay, corruption ratio by increasing the number of nodes and hence also analyzing the system in saturation state. It’s found that Packet Corruption Ratio (PCR) with CSMA+DOSPA is minimized compared to CSMA. Thus, interference reduction in distributed homogenous nodes is substantially minimized.
The pleiotropic role of human secretin (hSCT) validates its potential use as a therapeutic agent. Nevertheless, the structure of secretin in complex with its receptor is necessary to develop a ...suitable therapeutic agent. Therefore, in an effort to design a three-dimensional virtual homology model and identify a peptide agonist and/or antagonist for the human secretin receptor (hSR), the significance of the primary sequence of secretin peptides in allosteric binding and activation was elucidated using virtual docking, FRET competitive binding and assessment of the cAMP response. Secretin analogs containing various N- or C-terminal modifications were prepared based on previous findings of the role of these domains in receptor binding and activation. These analogs exhibited very low or no binding affinity in a virtual model, and were found to neither exhibit in vitro binding nor agonistic or antagonistic properties. A parallel analysis of the analogs in the virtual model and in vitro studies revealed instability of these peptide analogs to bind and activate the receptor.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Measurements have been performed with scintillation crystals of LaBr3:Ce coupled to an array of Silicon Photomultipliers (SiPMs) in a 3 T magnetic field. The SiPMs were read out by digital data ...acquisition systems, including the GET electronics system. Inside of the B-field, energy resolution values of 3.82% FWHM at 661.7 keV are reported for a 1.5′′ cubic LaBr3:Ce crystal coupled to a 6 × 6 array of 6 × 6 mm2 SiPMs. No measurable degradation in energy resolution due to the presence of the strong magnetic field was observed.
An experiment was conducted at the GANIL/LISE3 facility to produce the 10+ isomer of 54Ni and measure its proton radioactivity decay branches. The proton detection was achieved with the ACTAR TPC ...device that enabled the separation of the small signal of the emitted proton from the large signal of the implanted ion, while the decay half-life is of the order of 150 ns. From the measured data, the emitted proton track length and the decay time of the ion can be extracted simultaneously. The full proton radioactivity pattern could be established, with two emission branches and their relative branching ratio. Data processing and analysis that allowed to identify and separate the ion and the proton signals in order to reconstruct the particles trajectories and decay time are detailed. The evaluation of the detection efficiency for the proton radioactivity branches based on a full simulation is described.
Aims The study was initiated to analyse and characterize application of graphene on to heart valves, and also to evaluate the morphology of graphene after accelerated wear test in saline.
Methods ...Monolayer graphene was transferred to four bi-leaflet mechanical mitral valves. Three valves were subjected to accelerated wear test to 40M cycles in saline. Subsequently, after completion of the test, all the valves were evaluated by scanning electron microscopy. One bi-leaflet valve coated with graphene and another one which was not coated with graphene served as control.
Results A definite presence of graphene by SEM analysis was observed in various locations in 2 out of 3 valves analysed by accelerated wear test. As the valve surface was relatively rough, and the magnification was very high though graphene traces were not seen on the third valve, its presence cannot be ruled out. The surface morphology of the mitral valves was not changed at the completion of the study, by application of graphene.
Conclusion Graphene could be applied to mechanical bi-leaflet heart valves, and its presence was seen in 2 out of 3 valves after an accelerated wear test of 40M test cycles in saline.
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