We explore routing of propagating phonons in analogy with previous experiments on photons. Surface acoustic waves (SAWs) in the microwave regime are scattered by a superconducting transmon qubit. The ...transmon can be tuned on or off resonance with the incident SAW field using an external magnetic field or the Autler-Townes effect, and thus the reflection and transmission of the SAW field can be controlled in time. We observe 80% extinction in the transmission of the low power continuous signal and a 40 ns rise time of the router. The slow propagation speed of SAWs on solid surfaces allows for in-flight manipulations of the propagating phonons. The ability to route short, 100 ns, pulses enables new functionality, for instance to catch an acoustic phonon between two qubits and then release it in a controlled direction.
We report results of a microscopic calculation of a second-order phase transition into a state-breaking time-reversal and translational invariance along pair-breaking edges of d-wave superconductors. ...By solving a tight-binding model through exact diagonalization with the Bogoliubov–de Gennes method, we find that such a state with current loops having a diameter of a few coherence lengths is energetically favorable below T∗ between 10%–20% of Tc of bulk superconductivity, depending on model parameters. This extends our previous studies of such a phase crystal within the quasiclassical theory of superconductivity, and shows that the instability is not qualitatively different when including a more realistic band structure and the fast oscillations on the scale of the Fermi wavelength. Effects of size quantization and Friedel oscillations are not detrimental. We also report on a comparison with quasiclassical theory with the Fermi surfaces extracted from the tight-binding models used in the microscopic calculation. There are quantitative differences in for instance the value of T∗ between the different models, but we can explain the predicted transition temperature within each model as due to the different spectral weights of zero-energy Andreev bound states and the resulting gain in free energy by breaking time-reversal and translational invariance below T∗.
A group of Swedish radiation oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy in a facility where one of the principal aims is to ...facilitate randomized and other studies in which the advantage of protons can be shown and the magnitude of the differences compared with optimally administered conventional radiation treatment, also including intensity-modulated radiation therapy (IMRT) and brachytherapy, can be shown. The estimations have been based on current statistics of tumour incidence in Sweden, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours together with information on normal tissue complication rates. In Sweden, it is assessed that between 2200 and 2500 patients annually are eligible for proton beam therapy, and that for these patients the potential therapeutic benefit is so great as to justify the additional expense of proton therapy. This constitutes between 14-15% of all irradiated patients annually.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Children identified with stage 1 type 1 diabetes are at high risk for progressing to stage 3 (clinical) diabetes and require accurate monitoring. Our aim was to establish continuous glucose ...monitoring (CGM) metrics that could predict imminent progression to diabetes.
In the Autoimmunity Screening for Kids study, 91 children who were persistently islet autoantibody positive (median age 11.5 years; 48% non-Hispanic White; 57% female) with a baseline CGM were followed for development of diabetes for a median of 6 (range 0.2-34) months. Of these, 16 (18%) progressed to clinical diabetes in a median of 4.5 (range 0.4-29) months.
Compared with children who did not progress to clinical diabetes (nonprogressors), those who did (progressors) had significantly higher average sensor glucose levels (119 vs. 105 mg/dL, P < 0.001) and increased glycemic variability (SD 27 vs. 16, coefficient of variation, 21 vs. 15, mean of daily differences 24 vs. 16, and mean amplitude of glycemic excursions 43 vs. 26, all P < 0.001). For progressors, 21% of the time was spent with glucose levels >140 mg/dL (TA140) and 8% of time >160 mg/dL, compared with 3% and 1%, respectively, for nonprogressors. In survival analyses, the risk of progression to diabetes in 1 year was 80% in those with TA140 >10%; in contrast, it was only 5% in the other participants. Performance of prediction by receiver operating curve analyses showed area under the curve of ≥0.89 for both individual and combined CGM metric models.
TA140 >10% is associated with a high risk of progression to clinical diabetes within the next year in autoantibody-positive children. CGM should be included in the ongoing monitoring of high-risk children and could be used as potential entry criterion for prevention trials.
OBJECTIVE
To assess anxiety and risk perception among parents whose children screened positive for islet autoantibodies, indicating elevated risk for type 1 diabetes (T1D).
RESEARCH DESIGN AND ...METHODS
The Autoimmunity Screening for Kids (ASK) study identified 319 children age 1 to 17 years at risk for T1D via screening for islet autoantibodies; 280 children with confirmed islet autoantibodies and their caregivers enrolled in a follow-up education and monitoring program to prevent diabetic ketoacidosis at diagnosis. Parents completed questionnaires at each monitoring visit, including a 6-item version of the State Anxiety Inventory (SAI), to assess anxiety about their child developing T1D, and a single question to assess risk perception.
RESULTS
At the first ASK follow-up monitoring visit, mean parental anxiety was elevated above the clinical cutoff of 40 (SAI 46.1 ± 11.2). At the second follow-up monitoring visit (i.e., visit 2), mean anxiety remained elevated but started to trend down. Approximately half (48.9%) of parents reported their child was at increased risk for T1D at the initial follow-up monitoring visit (visit 1). Parents of children with more than one islet autoantibody and a first-degree relative with T1D were more likely to report their child was at increased risk.
CONCLUSIONS
Most parents of autoantibody-positive children have high anxiety about their child developing T1D. Information about the risk of developing T1D is difficult to convey, as evidenced by the wide range of risk perception reported in this sample.
When deciding whether to vaccinate, people often seek information through consequential processes that are not currently well understood. A survey of a nationally representative sample of U.S. adults ...(N = 2,091) explored the factors associated with intentions to seek influenza vaccine information in the 2018–2019 influenza season. This survey shed light on what motivates intentions to seek information about the influenza vaccine through the lens of the risk information seeking and processing (RISP) model. The model explained information‐seeking intentions well among both unvaccinated and vaccinated respondents. Key findings show that informational subjective norms, information insufficiency, and different types of affect are strong predictors of information‐seeking intentions. Theoretical insights on extending the RISP model and practical guidance on designing interventions are provided.
Electroactive polymers (EAP) deform under electric fields. This effect in fact generates various new fields of engineering applications of high technological interest. As an advantage, EAP may ...undergo deformations much larger than those capable by electroactive ceramics—however, to the price of acting at comparatively low forces. As common for polymers, EAP exhibit time-dependent material behaviour. The model proposed in this contribution, on the one hand, captures these electro-viscoelastic effects and, on the other hand, also nicely fits into iterative finite element formulations in order to simulate general boundary value problems. While the deformation itself as well as the electric potential are introduced as global degrees of freedom, the internal variables accounting for the viscous response are incorporated at the so-called local integration point level. Apart form calibrating the model against experimental data, a simple coupled finite element example is studied to show the applicability of the finite deformation electro-viscoelastic formulation proposed.
Evidence is emerging from school-based studies that physical activity might favorably affect children's academic performance. However, there is a need for high-quality studies to support this. ...Therefore, the main objective of the Active Smarter Kids (ASK) study is to investigate the effect of daily physical activity on children's academic performance. Because of the complexity of the relation between physical activity and academic performance it is important to identify mediating and moderating variables such as cognitive function, fitness, adiposity, motor skills and quality of life (QoL). Further, there are global concerns regarding the high prevalence of lifestyle-related non-communicable diseases (NCDs). The best means to address this challenge could be through primary prevention. Physical activity is known to play a key role in preventing a host of NCDs. Therefore, we investigated as a secondary objective the effect of the intervention on risk factors related to NCDs. The purpose of this paper is to describe the design of the ASK study, the ASK intervention as well as the scope and details of the methods we adopted to evaluate the effect of the ASK intervention on 5 (th) grade children.
The ASK study is a cluster randomized controlled trial that includes 1145 fifth graders (aged 10 years) from 57 schools (28 intervention schools; 29 control schools) in Sogn and Fjordane County, Norway. This represents 95.3 % of total possible recruitment. Children in all 57 participating schools took part in a curriculum-prescribed physical activity intervention (90 min/week of physical education (PE) and 45 min/week physical activity, in total; 135 min/week). In addition, children from intervention schools also participated in the ASK intervention model (165 min/week), i.e. a total of 300 min/week of physical activity/PE. The ASK study was implemented over 7 months, from November 2014 to June 2015. We assessed academic performance in reading, numeracy and English using Norwegian National tests delivered by The Norwegian Directorate for Education and Training. We assessed physical activity objectively at baseline, midpoint and at the end of the intervention. All other variables were measured at baseline and post-intervention. In addition, we used qualitative methodologies to obtain an in-depth understanding of children's embodied experiences and pedagogical processes taking place during the intervention.
If successful, ASK could provide strong evidence of a relation between physical activity and academic performance that could potentially inform the process of learning in elementary schools. Schools might also be identified as effective settings for large scale public health initiatives for the prevention of NCDs.
Clinicaltrials.gov ID nr: NCT02132494 . Date of registration, 6(th) of May, 2014.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This study screens more than 50 000 youths in diverse populations of Colorado and Bavaria to assess whether previous SARS-CoV-2 infection was associated with autoimmunity, which predicts future type ...1 diabetes.
PDF
