51.
Le recueil littéraire
Alduy, Cécile; Asselin, Isabelle; Audet, René ...
2003
eBook, Book
Architecte d'une œuvre plurielle, le recueil est de toutes nos lectures. Puzzle ou série, cycle ou mélange, il se feuillette, se reprend, se quadrille ou se picore. Mais qu'est-ce donc qu'un recueil ?
Dostopno za:
NUK, UL, UM, UPUK
52.
Differential effect of high doses versus low doses of interleukin‐12 on the adoptive transfer of human specific cytotoxic T lymphocyte in autologous lung tumors engrafted into severe combined immunodeficiency disease–nonobese diabetic mice
Asselin‐Paturel, Carine; Megherat, Smaïl; Vergnon, Isabelle ...
Cancer,
1 January 2001, Letnik:
91, Številka:
1
Journal Article
BACKGROUND
Interleukin (IL)‐12 can enhance the development of effective immune responses against tumors as well as against certain infectious agents. It is therefore a potential candidate for ...
therapeutic use in cancer therapy and in design of vaccines against several infectious diseases.
METHODS
The authors have established a specific cytotoxic T‐cell line (TIL‐Heu) from lymphocytes infiltrating a human large cell carcinoma of the lung (LCC). In the current report, the authors have investigated the in vivo effect of recombinant human IL‐12 (rhIL‐12) on the adoptive transfer of TIL‐Heu cells in autologous tumor (Heu‐n) engrafted into severe combined immunodeficiency disease–nonobese diabetic (SCID‐NOD) mice.
RESULTS
Initial in vitro experiments indicated that rhIL‐12 increased the cytotoxic potential of TIL‐Heu cells in a dose‐dependent manner. Heu‐n tumors transplanted into SCID‐NOD mice were injected with TIL‐Heu cells, resulting in a significant tumor growth inhibition. When low doses of rhIL‐12 were injected intratumorally after TIL‐Heu transfer, a clear increase in tumor growth suppression was observed. Surprisingly, higher doses of rhIL‐12 had no effect on cytotoxic T lymphocyte (CTL)–induced prevention of tumor growth. Further in vitro experiments revealed an inhibition of tumor cell lysis after incubation with supernatant of TIL‐Heu cells stimulated with high doses of rhIL‐12, strongly suggesting that an immunosuppressive factor secreted by the high dose IL‐12–stimulated CTL may be responsible for the tumor escape observed in vivo.
CONCLUSIONS
The authors' data indicate that IL‐10 may play a critical role in the lack of effect of high dose IL‐12, by mediating tumor cell resistance to CTL killing. Therefore, understanding the cross‐talk between immunoregulatory and immunosuppressive cytokines ultimately may provide new approaches to improve cytokine‐mediated cancer immunotherapy. Cancer 2001;91:113–22. © 2001 American Cancer Society.
This report demonstrates that, in contrast with low doses of human interleukin (IL)‐12, high doses have no effect on the growth of human lung tumors engrafted into severe combined immunodeficiency disease–nonobese diabetic mice, and adoptively transferred with a specific autologous cytotoxic cell line. The authors' data indicate that IL‐10 may play a critical role in the lack of effect of high dose IL‐12, by mediating tumor cell resistance to cytotoxic T lymphocyte killing.
več
Dostopno za:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
53.
Dostopno za:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
54.
Soutiens à la numérisation
Alduy, Cécile; Asselin, Isabelle; Audet, René ...
Le recueil littéraire,
07/2016
Journal Article
Ouvrage numérisé avec le soutien du Centre national du livre et de la région Bretagne
Dostopno za:
NUK, UL, UM, UPUK
PDF
