Liver Wang, Hanlin L.; Anderson, Christopher D.; Glasgow, Sean ...
Pathology of Solid Organ Transplantation
Book Chapter
The aim of this chapter is to present an up-to-date comprehensive review of pathology, pathophysiology and clinical perspectives related to liver transplantation. It is written for trained ...pathologists, hepatologists and transplant surgeons who are interested in developing expertise in the field of liver transplantation. Classic and unusual patterns of allograft rejection, recurrent and de novo liver diseases, technical complications, complications of immunosuppression and donor liver evaluation are illustrated in detail and emphasis is placed on biopsy interpretation. This chapter also includes contributions by experienced liver transplant surgeons and hepatologists who share their valuable expertise with pathologists to help pathologists better understand the clinical background and patient management when interpreting allograft biopsies.
3-carboxytetrahydroisoquinolines are aromatized on reaction with thionyl chloride. An axial carboxy group is lost in this process but one in the equatorial conformation is retained.
The effects of thyroid hormones on prolactin (PRL) and growth hormone (GH) synthesis by the rat anterior pituitary gland were assessed in vitro. A marked reduction (84-87%) in the rate of H3-leucine ...incorporation into GH was evident 2-4 weeks after thyroidectomy, while incorporation into PRL was 52-71% less than that measured in glands from intact rats. A single injection of T4 (200 mug/kg) administered to thyroidectomized (THX) rats 48 hr before sacrifice significantly increased incorporation into both pituitary hormones, although the stimulation of GH synthesis was much more dramatic. Perphenazine, alpha-methyltyrosine and estrogen enhanced the rate of PRL synthesis in intact rats. Thyroid ablation did not affect the response to perphenazine, but significantly increased the response to alpha-methyltyrosine and estrogen. On the other hand, administration of T4 to THX rats receiving perphenazine, alpha-methyltyrosine or estrogen diminished the stimulatory influence of these treatments on PRL synthesis. Perphenazine, alpha-methyltyrosine and estrogen had no effect on the rate of GH synthesis in THX rats, nor did they alter the ability of T4 to restore GH synthesis in these animals. These results indicate that GH synthesis in the rat is dependent upon thyroid hormones and support the concept that these hormones exert their stimulatory effect directly on pituitary somatotrophs. Pituitary lactotrophs, however, appear to retain much of their capacity to synthesize PRL under conditions of thyroid deficiency. The changes in pituitary PRL levels and synthesis rate induced by thyroid ablation might reflect differences in the number rather than the activity of these cells.
The Social Order Augustine, Brother D.; Bierstedt, Robert
The American Catholic Sociological Review,
06/1958, Letnik:
19, Številka:
2
Book Review, Journal Article
THE AMERICAN PEACE SOCIETY ON THE CHILIAN DIFFICULTY PAINE, ROBERT TREAT; Allen, J. H.; Allen, Nathaniel T. ...
The American advocate of peace and arbitration,
03/1892, Letnik:
54, Številka:
2
Journal Article
