Safer conception interventions reduce HIV incidence while supporting the reproductive goals of people living with or affected by HIV. We developed a consensus statement to address demand, summarize ...science, identify information gaps, outline research and policy priorities, and advocate for safer conception services. This statement emerged from a process incorporating consultation from meetings, literature, and key stakeholders. Three co-authors developed an outline which was discussed and modified with co-authors, working group members, and additional clinical, policy, and community experts in safer conception, HIV, and fertility. Co-authors and working group members developed and approved the final manuscript. Consensus across themes of demand, safer conception strategies, and implementation were identified. There is demand for safer conception services. Access is limited by stigma towards PLWH having children and limits to provider knowledge. Efficacy, effectiveness, safety, and acceptability data support a range of safer conception strategies including ART, PrEP, limiting condomless sex to peak fertility, home insemination, male circumcision, STI treatment, couples-based HIV testing, semen processing, and fertility care. Lack of guidelines and training limit implementation. Key outstanding questions within each theme are identified. Consumer demand, scientific data, and global goals to reduce HIV incidence support safer conception service implementation. We recommend that providers offer services to HIV-affected men and women, and program administrators integrate safer conception care into HIV and reproductive health programs. Answers to outstanding questions will refine services but should not hinder steps to empower people to adopt safer conception strategies to meet reproductive goals.
The sesquiterpene lactones eupatoriopicrin, estafietin, eupahakonenin B and minimolide have been isolated from Argentinean Astearaceae species and have been found to be active against
epimastigotes. ...The aim of this work was to evaluate the activity of these compounds by analyzing their effect against the stages of the parasites that are infective for the human. Even more interesting, we aimed to determine the effect of the most active and selective compound on an
model of
infection. Eupatoriopicrin was the most active against amastigotes and tripomastigotes (IC
= 2.3 µg/mL, and 7.2 µg/mL, respectively) and displayed a high selectivity index. This compound was selected to study on an
model of
infection. The administration of 1 mg/kg/day of eupatoriopicrin for five consecutive days to infected mice produced a significant reduction in the parasitaemia levels in comparison with non-treated animals (area under parasitaemia curves 4.48 vs. 30.47, respectively). Skeletal muscular tissues from eupatopicrin-treated mice displayed only focal and interstitial lymphocyte inflammatory infiltrates and small areas of necrotic; by contrast, skeletal tissues from
infected mice treated with the vehicle showed severe lymphocyte inflammatory infiltrates with necrosis of the adjacent myocytes. The results indicate that eupatoriopicrin could be considered a promising candidate for the development of new therapeutic agents for Chagas disease.
Single-phased La0.6Sr0.4Co1-yFeyO3-δ (y = 0.2, 0.5, 0.8) nanorods exhibiting the rhombohedral perovskite-type phase were synthesized by a pore-wetting technique. We studied their chemical ...composition, crystal and electronic structures, morphology and hyperfine properties as a function of the Co/Fe content of the samples. Our results demonstrate that Co cations exhibit a slightly lower oxidation state than Fe ones, resulting in a higher oxygen non-stoichiometry δ for Co-rich samples. In addition, the values of δ determined in this work for nanostructured samples are much higher than those reported in the literature for bulk materials. This can be attributed to the high number of defects in nanomaterials and is probably one important factor in the high electrochemical performance for the oxygen reduction reaction of nanostructured La0.6Sr0.4Co1-yFeyO3-δ IT-SOFC cathodes, which have been reported in a previous work.
•Single-phased LSCF nanorods with rhombohedral perovskite-type phase were synthesized.•Co and Fe average oxidation states and chemical environment are similar for all the compositions studied in this work.•Co exhibit a slightly lower oxidation state than Fe, resulting in a higher oxygen non-stoichiometry δ for Co-rich samples.•Nanorod-like samples exhibit higher d than bulk materials reported in the literature, probably due to their high disorder.•These results explain the high performance of nanostructured LSCF cathodes reported in our previous works.
Currently, the vast majority of genomic research cohorts are made up of participants with European ancestry. Genomic medicine will only reach its full potential when genomic studies become more ...broadly representative of global populations. We are working to support the establishment of genomic medicine in developing countries in Latin America
via
studies of ethnically and ancestrally diverse Colombian populations. The goal of this study was to analyze the effect of ethnicity and genetic ancestry on observed disease prevalence and predicted disease risk in Colombia. Population distributions of Colombia’s three major ethnic groups – Mestizo, Afro-Colombian, and Indigenous – were compared to disease prevalence and socioeconomic indicators. Indigenous and Mestizo ethnicity show the highest correlations with disease prevalence, whereas the effect of Afro-Colombian ethnicity is substantially lower. Mestizo ethnicity is mostly negatively correlated with six high-impact health conditions and positively correlated with seven of eight common cancers; Indigenous ethnicity shows the opposite effect. Malaria prevalence in particular is strongly correlated with ethnicity. Disease prevalence co-varies across geographic regions, consistent with the regional distribution of ethnic groups. Ethnicity is also correlated with regional variation in human development, partially explaining the observed differences in disease prevalence. Patterns of genetic ancestry and admixture for a cohort of 624 individuals from Medellín were compared to disease risk inferred
via
polygenic risk scores (PRS). African genetic ancestry is most strongly correlated with predicted disease risk, whereas European and Native American ancestry show weaker effects. African ancestry is mostly positively correlated with disease risk, and European ancestry is mostly negatively correlated. The relationships between ethnicity and disease prevalence do not show an overall correspondence with the relationships between ancestry and disease risk. We discuss possible reasons for the divergent health effects of ethnicity and ancestry as well as the implication of our results for the development of precision medicine in Colombia.
Starch is a versatile and a widely used ingredient, with applications in many industries including adhesive and binding, paper making, corrugating, construction, paints and coatings, chemical, ...pharmaceutical, textiles, oilfield, food and feed. However, native starches present limited applications, which impairs their industrial use. Consequently, starch is commonly modified to achieve desired properties. Chemical treatments are the most exploited to bring new functionalities to starch. However, those treatments can be harmful to the environment and can also bring risks to the human health, limiting their applications. In this scenario, there is a search for techniques that are both environmentally friendly and efficient, bringing new desired functionalities to starches. Therefore, this review presents an up-to-date overview of the available literature data regarding the use of environmentally friendly treatments for starch modification. Among them, we highlighted an innovative chemical treatment (ozone) and different physical treatments, as the modern pulsed electric field (PEF), the emerging ultrasound (US) technology, and two other treatments based on heating (dry heating treatment - DHT, and heat moisture treatment - HMT). It was observed that these environmentally friendly technologies have potential to be used for starch modification, since they create materials with desirable functionalities with the advantage of being categorized as clean label ingredients.
ABSTRACT
In this work, we characterize the properties of the object SDSS J020536.84−081424.7, an extended nebular region with projected extension of 14 × 14 kpc2 in the line of sight of the ETG ...Mrk 1172, using unprecedented spectroscopic data from MUSE. We perform a spatially resolved stellar population synthesis and estimate the stellar mass for both Mrk 1172 (1 × 1011 M⊙) and our object of study (3 × 109 M⊙). While the stellar content of Mrk 1172 is dominated by an old (∼10 Gyr) stellar population, the extended nebular emission has its light dominated by young to intermediate age populations (from ∼100 Myr to ∼1 Gyr) and presents strong emission lines such as H β; O iii λλ4959, 5007 Å; H α; N ii λλ6549, 6585 Å; and S ii λλ6717, 6732 Å. Using these emission lines, we find that it is metal poor (with Z ∼ 1/3 Z⊙, comparable to the LMC) and is actively forming stars (0.70 M⊙ yr−1), especially in a few bright clumpy knots that are readily visible in H α. The object has an ionized gas mass ≥3.8 × 105 M⊙. Moreover, the motion of the gas is well described by a gas in circular orbit in the plane of a disc and is being affected by interaction wtih Mrk 1172. We conclude that SDSS J020536.84−081424.7 is most likely a dwarf irregular galaxy (the dIGal).
Advancing with our project about the development of new antiparasitic agents, we have enzymatically synthesized a series of amides derived from amlodipine, a calcium channel blocker used as an ...antihypertensive drug. Through lipase-catalyzed acylation with different carboxylic acids, nineteen amlodipine derivatives were obtained, eighteen of which were new compounds. To optimize the reaction conditions, the influence of several reaction parameters was analyzed, finding different requisites for aliphatic carboxylic acids and phenylacetic acids. All synthesized compounds were evaluated as antiproliferative agents against
, the etiological agent of American trypanosomiasis (Chagas' disease). Some of them showed significant activity against the amastigote form of
, the clinically relevant form of the parasite. Among synthesized compounds, the derivatives of myristic and linolenic acids showed higher efficacy and lower cytotoxicity. These results added to the advantages shown by the enzymatic methodology, such as mild reaction conditions and low environmental impact, making this approach a valuable way to synthesize these amlodipine derivatives with an application as promising antiparasitic agents.
ABSTRACT
We present a spatially resolved stellar population analysis of 61 jellyfish galaxies and 47 control galaxies observed with ESO/MUSE attempting to understand the general trends of the stellar ...populations as a function of the stripping intensity and mass. This is the public sample from the GASP programme, with 0.01 < z < 0.15 and 8.9 < log (M⋆/M⊙) < 12.0. We apply the spectral population synthesis code fado to fit self-consistently both the stellar and nebular contributions to the spectra of the sources. We present 2D morphological maps for mean stellar ages, metallicities, gas-phase oxygen abundances, and star formation rates for the galaxies with Integrated Nested Laplace Approximation (inla), which is efficient in reconstructing spatial data of extended sources. We find that ‘extreme stripping’ and ‘stripping’ galaxies are typically younger than the other types. Regarding stellar and nebular metallicities, the ‘stripping’ and ‘control passive’ galaxies are the most metal-poor. Based on the phase space for jellyfish cluster members we find trends in ages, metallicities, and abundances with different regions of the diagram. We also compute radial profiles for the same quantities. We find that both the stripping and the stellar masses seem to influence the profiles, and we see differences between various groups and distinct mass bins. The radial profiles for different mass bins present relations already shown in the literature for undisturbed galaxies, i.e. profiles of ages and metallicities tend to increase with mass. However, beyond ∼0.75 effective radius, the ages of the most massive galaxies become similar to or lower than the ages of the lower mass ones.
ObjectiveDescription of tuberculosis (TB)-focused point-of-care ultrasound (POCUS) findings for children with presumptive TB.DesignCross-sectional study (July 2019 to April 2020).SettingSimão Mendes ...hospital in Bissau, a setting with high TB, HIV, and malnutrition burdens.ParticipantsPatients aged between 6 months and 15 years with presumptive TB.InterventionsParticipants underwent clinical, laboratory and unblinded clinician-performed POCUS assessments, to assess subpleural nodules (SUNs), lung consolidation, pleural and pericardial effusion, abdominal lymphadenopathy, focal splenic and hepatic lesions and ascites. Presence of any sign prompted a POCUS positive result. Ultrasound images and clips were evaluated by expert reviewers and, in case of discordance, by a second reviewer. Children were categorised as confirmed TB (microbiological diagnosis), unconfirmed TB (clinical diagnosis) or unlikely TB. Ultrasound findings were analysed per TB category and risk factor: HIV co-infection, malnutrition and age.ResultsA total of 139 children were enrolled, with 62 (45%) women and 55 (40%) aged <5 years; 83 (60%) and 59 (42%) were severely malnourished (SAM) and HIV-infected, respectively. TB confirmation occurred in 27 (19%); 62 (45%) had unconfirmed TB and 50 (36%) had unlikely TB. Children with TB were more likely to have POCUS-positive results (93%) compared with children with unlikely TB (34%). Common POCUS signs in patients with TB were: lung consolidation (57%), SUNs (55%) and pleural effusion (30%), and focal splenic lesions (28%). In children with confirmed TB, POCUS sensitivity was 85% (95% CI) (67.5% to 94.1%). In those with unlikely TB, specificity was 66% (95% CI 52.2% to 77.6%). Unlike HIV infection and age, SAM was associated with a higher POCUS-positivity. Cohen’s kappa coefficient for concordance between field and expert reviewers ranged from 0.6 to 0.9.ConclusionsWe found a high prevalence of POCUS signs in children with TB compared with children with unlikely TB. POCUS-positivity was dependent on nutritional status but not on HIV status or age. TB-focused POCUS could potentially play a supportive role in the diagnosis of TB in children.Trial registration numberNCT05364593.
•Controversial results in literature about non-thermal effects of electric fields.•Unreliable methods and assumptions can compromise results and conclusions.•Control and distribution of temperature ...and electric field are key factors.•Comparison with conventional process must be fair.•Depending on field frequency, effects may be subtle and difficult to assess.
The use of microwave and ohmic heating in food processing has the advantage of a fast volumetric heating due to ionic and dielectric mechanisms, depending on field frequency. One topic that has been under debate is whether or not the electric field has a non-thermal effect that enhances the inactivation of microorganisms and enzymes. Numerous studies with controversial have been conducted using different approaches, experimental designs and methodologies. This review discusses important factors for accurately assessing non-thermal effects, such as distribution and control of electric field and temperature, measurement of time temperature history, sample homogeneity, fair comparison with conventional processed samples. Current theories for non-thermal inactivation of enzymes (structure and functionally changes) and micro-organisms (cell membrane changes) are also reviewed.
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