Azide-tagged copper(I) complexes of N-heterocyclic carbenes (NHCs) analogous to the well-known bis2,6-diisopropylphenylimidazol-2-ylidene (IPr) and bis2,6-diisopropylphenylimidazolin-2-ylidene (SIPr) ...were synthesized and characterized. These complexes were able to act as catalyst and substrate in a model copper-catalyzed azide–alkyne (CuAAC) reaction with propargyl alcohol, yielding functionalized copper(I)-NHC complexes.
A simple addition with a large impact: Addition of aromatic amines such as phenanthroline and 4‐DMAP (4‐dimethylaminopyridine) increases copper(I)‐catalyzed azide alkyne cycloaddition (CuAAC) ...catalytic activity of CuCl(SIMes) at a large range of temperatures in such a way that efficient catalysis can safely take place in hydro‐alcoholic solvents (see scheme).
A simple addition with a large impact: Addition of aromatic amines such as phenanthroline and 4‐DMAP (4‐dimethylaminopyridine) increases copper(I)‐catalyzed azide alkyne cycloaddition (CuAAC) catalytic activity of CuCl(SIMes) at a large range of temperatures in such a way that efficient catalysis can safely take place in hydro‐alcoholic solvents (see scheme).
We have previously demonstrated that pyrrolo2,3-acarbazole-3-carbaldehydes are potent Pim kinase inhibitors with in vitro antiproliferative activities. In the present study, we report the synthesis ...of new pyrrolocarbazoles substituted at the N-10 position. When their ability to inhibit Pim kinase activities were evaluated in in vitro assays, we observed that this nitrogen atom can be substituted without loss of Pim-1 and Pim-3 inhibitory potencies. Moreover, when we added a fluorescent dansyl group (compound 13), we were able to show that 13 penetrates the plasma membrane and enters the cytoplasm.
Copper (I) Catalyzed Azide Alkyne Cycloaddition (CuAAC) was used for N-10 functionalization of pyrrolo2,3-acarbazole kinase inhibitors. CuAAC also enabled the grafting of a fluorescent tracer. Display omitted
► CuAAC reaction was used for the preparation of conjugated pyrrolo2,3-acarbazoles. ► We evaluated Pim kinase inhibitory potency of conjugated pyrrolo2,3-acarbazoles. ► Cellular localisation of a fluorescent derivative was determined. ► N-10 can be substituted without loosing inhibitory potencies against Pim-1 or Pim-3.
The sol–gel chemistry route has successfully been used to prepare samples of LnP
5
O
14
(Ln = La, Gd) pentaphosphates from lanthanides chlorides and phosphorous pentoxide dissolved in isopropanol. ...Crystallized powders of single phase were obtained after calcination of gels at 350 °C. The structural characterizations of materials were investigated by means of X-ray diffraction as well as infrared and Raman spectroscopies, whereas their thermal behavior has been studied by differential thermal analyse and thermogravimetric analyses. Powders morphology was analyzed by means of scanning electron microscopy and laser granulometry. The photoluminescence properties of the Eu
3+
ions in sol–gel derived LaP
5
O
14
and GdP
5
O
14
samples were investigated and compared with homologous samples synthesized by the conventional solid state reaction.
Single crystals of Ca
5
Zr
3
F
22
, pentacalcium trizirconium docosafluoride, were obtained unexpectedly by solid-state reaction between CaF
2
and ZrF
4
in the presence of AgF. The structure of the ...title compound is isotypic with that of Sr
5
Zr
3
F
22
and can be described as being composed of layers with composition Zr
3
F
20
8−
made up from two different ZrF
8
4−
square antiprisms (one with site symmetry 2) by corner-sharing. The layers extending parallel to the (001) plane are further linked by Ca
2+
cations, forming a three-dimensional network. Amongst the four crystallographically different Ca
2+
ions, three are located on twofold rotation axes. The Ca
2+
ions exhibit coordination numbers ranging from 8 to 12, depending on the cut off, with very distorted fluorine environments. Two of the Ca
2+
ions occupy interstices between the layers whereas the other two are located in void spaces of the Zr
3
F
20
8−
layer and alternate with the two Zr atoms along 010. The crystal under investigation was an inversion twin.
In the structure of the title compound, (C5H7N2)Cr(C2O4)2(H2O)2, two crystallographically independent formula units are present. Both chromium atoms are six-coordinated in a distorted octahedral ...geometry by two chelating equatorial oxalato ligands and two axial water molecules. The Cr(C2O4)2(H2O)2− anions and C5H7N2+ cations are linked through a complex three-dimensional hydrogen-bonding network consisting of N—H...O and O—H...O interactions.
In the title compound, Cu(C(6)H(6)N(4))(2)(C(9)H(5)N(4)O)(2), the Cu(2+) ion (site symmetry ) is coordinated by two N,N'-bidentate 2,2'-biimidazole (H(2)biim) ligands, generating a square-planar ...CuN(4) geometry. The dihedral angle between the aromatic rings in the ligand is 0.70 (9)°. In the polynitrile 1,1,3,3-tetra-cyano-2-eth-oxy-propenide (tcnoet) anion, the C-N, C-C and C-O bond lengths indicate extensive electronic delocalization. An alternative description for the metal-ion geometry is an extremely distorted CuN(6) octa-hedron, with two N-bonded tcnoet anions completing the coordination. In the crystal, the components are linked by N-H⋯N and C-H⋯N inter-actions.
The title compound, C16H24Cl2O, was synthesized from β-himachalene (3,5,5,9-tetramethyl-2,4a,5,6,7,8-hexahydro-1H-benzocycloheptene), which was isolated from the essential oil of the Atlas cedar ...(cedrus atlantica). The molecule forms an extended sheet of two fused rings which exhibit different conformations. The six-membered ring has a half-chair conformation, while the seven-membered ring displays a chair conformation; the dihedral angle between the two rings is 38.2 (1)°.
In the monomeric title complex, Co(C6H8O4)(C10H9N3)(H2O)2*3H2O, the distorted octahedral CoN2O4 coordination environment comprises two N-atom donors from the bidentate dipyridyldiamine ligand, two ...O-atom donors from one of the carboxylate groups of the bidentate chelating adipate ligand and two water molecules. In addition, there are three solvent water molecules which are involved in both intra- and inter-unit O-H...O hydrogen-bonding interactions, which together with an amine-water N-H...O hydrogen bond produce a three-dimensional framework.
The electrochemical reduction of molten Li–Na–K carbonates at the eutectic composition was (43.5/31.5/25
mol%) performed in the range 450–700
°C. The analysis of the electrochemical mechanism was ...done by cyclic voltammetry with an inert vitreous carbon electrode. “Quasi-spherical” carbonaceous particles were obtained with average diameter comprised between 30 and 50
nm. The specific surface area as well as the crystallinity and morphology of the powders were strongly influenced by the operating conditions, i.e. potential deposition, temperature of the molten carbonates, temperature of the drying process after washing. The carbon prepared in our experimental conditions contains micro-, meso- and macroporisty. The proportion of each one is strongly dependent on the operating deposition conditions. The highest specific surface area value (1315
m
2
g
−1) was obtained with carbon powder deposited at 450
°C for an applied potential of −6
V and dried at 600
°C under vacuum after washing.
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