Background: Focal therapy (FT) is an option to treat localized prostate cancer (PCa) and preserve healthy prostate tissue in order to reduce known side effects from primary whole-gland treatment. The ...available FT modalities are manifold. Until now, national and international PCa guidelines have been cautious to propose recommendations regarding FT treatment since data from prospective controlled trials are lacking for most FT modalities. Moreover, none of the international guidelines provides a separate section on FT. In this purpose, we provide a synopsis of the consensusbased German S3 guidelines for a possible international use. - Summary: The recently published update of the German S3 guidelines, an evidence- and consensus-based guideline, provides a section on FT with recommendations for diagnostic work-up, indications, modalities, and follow-up. This section consists of 12 statements and recommendations for FT in the treatment of localized PCa. Key Message: The German S3 guidelines on PCa are the first to incorporate recommendations for FT based on evidence and expert consensus including indication criteria for FT, pretreatment, and followup diagnostic pathways as well as an extended overview of FT techniques and the current supportive evidence.
ABSTRACT
Leo T is a gas-rich dwarf located at $414\, {\rm kpc}$ (1.4Rvir) distance from the Milky Way (MW) and it is currently assumed to be on its first approach. Here, we present an analysis of ...orbits calculated backwards in time for the dwarf with our new code delorean, exploring a range of systematic uncertainties, e.g. MW virial mass and accretion, M31 potential, and cosmic expansion. We discover that orbits with tangential velocities in the Galactic standard-of-rest frame lower than $| \vec{u}_{\rm t}^{\rm GSR}| \le 63^{+47}_{-39}\, {\rm km}\, {\rm s}^{\rm -1}$ result in backsplash solutions, i.e. orbits that entered and left the MW dark matter halo in the past, and that velocities above $| \vec{u}_{\rm t}^{\rm GSR}| \ge 21^{+33}_{-21}\, {\rm km}\, {\rm s}^{\rm -1}$ result in wide-orbit backsplash solutions with a minimum pericentre range of $D_{\rm min} \ge 38^{+26}_{-16}\, {\rm kpc}$, which would allow this satellite to survive gas stripping and tidal disruption. Moreover, new proper motion estimates overlap with our orbital solution regions. We applied our method to other distant MW satellites, finding a range of gas stripped backsplash solutions for the gasless Cetus and Eridanus II, providing a possible explanation for their lack of cold gas, while only first infall solutions are found for the H i-rich Phoenix I. We also find that the cosmic expansion can delay their first pericentre passage when compared to the non-expanding scenario. This study explores the provenance of these distant dwarfs and provides constraints on the environmental and internal processes that shaped their evolution and current properties.
In this work, we present a simple and efficient method for the preparation of hemin-modified SnO2 films on Metglas ribbon substrates for the development of a sensitive magneto-electrochemical sensor ...for the determination of H2O2. The SnO2 films were prepared at low temperatures, using a simple hydrothermal method, compatible with the Metglas surface. The SnO2 film layer was fully characterized by X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), photoluminescence (PL) and Fourier Transform-Infrared spectroscopy (FT-IR). The properties of the films enable a high hemin loading to be achieved in a stable and functional way. The Hemin/SnO2-Metglas system was simultaneously used as a working electrode (WE) for cyclic voltammetry (CV) measurements and as a magnetoelastic sensor excited by external coils, which drive it to resonance and interrogate it. The CV scans reveal direct reduction and oxidation of the immobilized hemin, as well as good electrocatalytic response for the reduction of H2O2. In addition, the magnetoelastic resonance (MR) technique allows the detection of any mass change during the electroreduction of H2O2 by the immobilized hemin on the Metglas surface. The experimental results revealed a mass increase on the sensor during the redox reaction, which was calculated to be 767 ng/μM. This behavior was not detected during the control experiment, where only the NaH2PO4 solution was present. The following results also showed a sensitive electrochemical sensor response linearly proportional to the concentration of H2O2 in the range 1 × 10−6–72 × 10−6 M, with a correlation coefficient of 0.987 and detection limit of 1.6 × 10−7 M. Moreover, the Hemin/SnO2-Metglas displayed a rapid response (30 s) to H2O2 and exhibits good stability, reproducibility and selectivity.
Leo T is a gas-rich dwarf located at 414kpc \((1.4R_{\rm vir})\) distance from the Milky Way (MW) and it is currently assumed to be on its first approach. Here, we present an analysis of orbits ...calculated backward in time for the dwarf with our new code {\sc delorean}, exploring a range of systematic uncertainties, e.g. MW virial mass and accretion, M31 potential, and cosmic expansion. We discover that orbits with tangential velocities in the Galactic Standard-of-Rest frame lower than \(|\vec{u}_{\rm t}^{\rm GSR}|\!\leq\! 63^{+47}_{-39}{\rm\, km\, s^{-1}}\) result in backsplash solutions, i.e. orbits that entered and left the MW dark matter halo in the past, and that velocities above \(|\vec{u}_{\rm t}^{\rm GSR}|\!\geq\!21^{+33}_{-21}{\rm\, km\, s^{-1}}\) result in wide orbit backsplash solutions with a minimum pericenter range of \(D_{\rm min}\!\geq\!38^{+26}_{-16}{\rm \,kpc}\), which would allow this satellite to survive gas stripping and tidal disruption. Moreover, new proper motion estimates match with our region of backsplash solutions. We applied our method to other distant MW satellites, finding a range of gas stripped backsplash solutions for the gas-less Cetus and Eridanus II, providing a possible explanation for their lack of cold gas, while only first in-fall solutions are found for the HI rich Phoenix I. We also find that the cosmic expansion can delay their first pericenter passage when compared to the non-expanding scenario. This study explores the provenance of these distant dwarfs and provides constraints on the environmental and internal processes that shaped their evolution and current properties.
PDF
