Development of nonmelanoma skin cancers (NMSCs) has been associated with certain risk factors, but studies of the association between ABO blood group and NMSCs have been rare and inconclusive. The ...aim of this study was to assess the association of the previously known risk factors and blood group as a new potential risk factor in NMSCs.
The study included 401 patients, 202 men, and 199 women, which included 367 diagnosed cases of basal cell carcinoma and 148 diagnosed cases of squamous cell carcinoma. The control group consisted of 438 subjects, 198 men, and 240 women. A standardized questionnaire adapted for this targeted study was used. The relation between the dependent variable (NMSCs) and independent variables was investigated by logistic regression.
Compared to the non AB blood group, the risk of developing NMSCs was significantly higher in the AB blood group (MOR = 2.28; 95% CI = 1.41-3.69). We established a logistic model that could best describe the probability of NMSCs development.
Study results are expected to instigate basic research into the role of A and B antigens in normal skin epithelium, NMSCs etiopathogenesis, possible effect on metastatic potential and disease prognosis, potential tumor immunotherapy, and targeted detection and prevention in subjects at an increased risk of NMSCs development.
To determine the prevalence of non-melanoma skin cancer (NMSC) and disease-specific risk factors in renal transplant recipients (RTRs).
This retrospective cohort study enrolled 1232 RTRs (736 men) ...treated in University Hospital Center Zagreb over 40 years. The effect of sex, age at transplantation, geographic residence, dialysis vintage, and the type of immunosuppressive therapy on NMSC occurrence was investigated.
The prevalence of NMSC was 6.81%. Overall, 60.7% of patients developed basal cell carcinoma (BCC) and 30.9% of patients developed cutaneous squamous cell carcinoma (cSCC). Only 8.3% developed both tumors. The BCC:cSCC ratio was 1.76:1. The risk for NMSC was 50% higher in men. Patients older than 50 years at transplantation were at greater risk for NMSC development. Residence in an area with higher ultraviolaet radiation (UV) exposure and dialysis vintage before transplantation did not influence NMSC development. Cyclosporine and azathioprine treatment conferred a greater risk for NMSC than tacrolimus or mycophenolate mofetil treatment.
RTRs are at high risk for NMSC development. Sex, age at transplantation, and type of immunosuppressive therapy play a role in tumor development.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Skin cancers are the most common malignancies in renal transplant recipients, with squamous-cell and basal-cell cancers accounting for the majority of all skin cancer cases. Melanoma is relatively ...rare in this group of patients. From 1973 to May 2017, out of 1889 patients who received allografts at our institution, 4 developed melanoma. After the mean follow-up of 11.5 months, 2 patients died and 2 are still alive with functioning allografts. Malignancies were localized in the legs in both female patients, and in the neck and head in 1 male patient each. Compared to the general population of Croatia, renal transplant recipients from our cohort have 6.85 times higher risk for development of melanoma. Regular screenings and patient education are mandatory, especially in Mediterranean countries.
Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Giant BCCs are quite rare. They can cause extensive local invasion, disfigurement, and metastasis. We present a case of a ...58-year-old woman with an unrecognized and inadequately treated ulcerated giant BCC sized 12.5 × 10.0 cm that occurred on her left lower leg without any sign of metastasis. Neglect and inadequate treatment of the primary lesion are the most important contributing factors responsible for size in giant BCC.
Nemelanomski karcinomi kože najčešći su karcinomi u bolesnika s transplantiranim bubregom. Kliničke i epidemiološke studije ukazuju na to da su najvažniji čimbenici rizika za razvoj nemelanomskih ...karcinoma kože doživotna imunosupresivna terapija nužna za sprječavanje odbacivanja presatka i održanje njegove funkcije te starija životna dob bolesnika prilikom transplantacije, izloženost UV zrakama tijekom života, svjetliji tipovi kože i osobna anamneza preboljelog karcinoma kože prije transplantacije. Budući da su bolesnici s transplantiranim bubregom skloniji razvoju agresivnijih tipova kožnih karcinoma, osobito planocelularnog karcinoma, izrazito je važno razviti svijest bolesnika s transplantatom o povećanoj sklonosti razvoju karcinoma kože, potrebi za prevencijom te redovitim dermatološkim pregledima i samopregledima kože. Imunosupresivnu terapiju treba prilagoditi svakom pojedinom bolesniku te ju po potrebi modificirati kako bi se smanjio rizik za pojavu karcinoma uz istodobno održanje funkcije presatka. Za praćenje bolesnika s transplantiranim bubregom potreban je interdisciplinarni pristup uključujući primarno nefrologe i dermatologe kako bismo omogućili bolesnicima s transplantatom prevenciju, ranu dijagnozu i odgovarajuće liječenje karcinoma kože.
Skin cancers are the most common malignancies in renal transplantrecipients, with squamous-cell and basal-cell cancers accounting for the majorityof all skin cancer cases. Melanoma is relatively rare ...in this group of patients.From 1973 to May 2017, out of 1889 patients who received allografts at our institution,4 developed melanoma. After the mean follow-up of 11.5 months, 2patients died and 2 are still alive with functioning allografts. Malignancies werelocalized in the legs in both female patients, and in the neck and head in 1 malepatient each. Compared to the general population of Croatia, renal transplantrecipients from our cohort have 6.85 times higher risk for development of melanoma.Regular screenings and patient education are mandatory, especially inMediterranean countries.
Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Giant BCCs are quite rare. They can cause extensive local invasion, disfigurement, and metastasis. We present a case of a ...58-year-old woman with an unrecognized and inadequately treated ulcerated giant BCC sized 12.5 × 10.0 cm that occurred on her left lower leg without any sign of metastasis. Neglect and inadequate treatment of the primary lesion are the most important contributing factors responsible for size in giant BCC.
The duodenum is rarely affected by neoplasms with less than 5% of gastrointestinal tumors being found in the small intestine. Nevertheless, they can be of great clinical significance. Usual symptoms ...include abdominal pain, acid reflux, constipation, and melena. While upper gastrointestinal bleeding is relatively frequent and occurs in around 100 per 100,000 adults per year, duodenal tumors are one of its rarest causes. The most common benign duodenal tumors are adenomas, followed by lipomas, haemangiomas, and leiomyomas
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