Paediatric facial fractures are relatively rare. The inherent elasticity of the bones with more of the cartilage than that of the mineralised bone accounts for this. The principles involved in the ...management of facial fractures are the same irrespective of the age of the patient; however, in children, the techniques used are necessarily modified by certain anatomical, physiological, psychological and feeding factors related to childhood and the parents. In an attempt to keep the treatment and fixation technique simple, the case, presented here, describes the management of a mandibular parasymphyseal fracture in a 16-month-old child with the use of a prefabricated adaptable surgical splint.
In this work, the effect of Cu content on structural and magnetic properties of Cobalt–Zinc Ferrite nanoparticles synthesized by sol–gel combustion method have been investigated. All the samples ...exhibit cubic spinel structure and the lattice constant decreases linearly with increasing Cu-content. Average crystallite sizes calculated from Debye–Scherrer formula are in the range of 51–100 nm. The broadening of X-ray diffraction peaks decrease with increasing Cu content ‘x’ suggest that crystallite size increases with increasing ‘x’. Cation distribution estimated form X-ray line intensity calculations show that Cu ions simultaneously occupy tetrahedral (A) and octahedral (B) sites with different ratio and Zn and Co ions occupies A and B sites respectively. With increasing Cu content a fraction of Co ions migrate to A site when x >0.2. Grain sizes estimated from SEM are found to be increase with increasing Cu content. Particle size calculated using TEM for the undoped Co–Zn ferrites is about 55 nm. Saturation magnetization (Ms), Coercivity (Hc) and remanent magnetization (Mr) that varies significantly with Cu-Content. Saturation magnetization decreases from 90.7 emu/g (x = 0.0) to 51 emu/g (x = 0.4). The proposed cation distribution supports the variation in saturation magnetization and Coercivity with increasing Cu content.
Co
0.5
Mg
0.5-
x
Cu
x
Fe
2
O
4
(
x
= 0.0, 0.2 and 0.4) nanoferrites were prepared by sol–gel auto combustion method. XRD, FT-IR, and HRTEM studies revealed the single-phase spinel cubic crystal ...structure of all samples with Fd-3 m space group. The lattice constant, calculated using the XRD data, was found in the range 8.3936–8.4735 Å. The average crystallite sizes were found to be in the range of between 38.8 and 49.9 nm. The microstructural behavior and elemental composition of all samples were detected by FE-SEM and EDS, respectively. FTIR curves showed two absorption bands
ʋ
1
with higher frequency and
ʋ
2
with a lower frequency, indicating metal cation and oxygen bond stretching at tetrahedral and octahedral sites. DC resistivity was decreased with increasing the content of copper. VSM study confirmed the ferrimagnetic behavior of all samples. The values of remnant ratios obtained from VSM data showed their isotropic nature forming single domains ferrimagnetic particles
Abstract
X-Ray fluorescence (XRF) is an effective method for chemical profile analysis of various materials. In earlier times, it is only confined to qualitative and quantitative analysis. This ...wavelength dispersive X Ray fluorescence (WDXRF) will be used to check the nuclear design of different Molybdenum compounds. The study of relative intensity ratios of various satellite peaks of Molybdenum (Mo) and Molybdenum trioxide (MoO
3
) compounds is associated with their atomic spectral structures. The intensity ratios will give the validity of the Hatree-slater model of different combinations. In this paper, we will present energy versus intensity and data obtained using WDXRF for the compounds Mo and MoO
3
. From this data, it will be seen that the L
β
line is resolved. From this we conclude that Coaster-Kronig transitions by double vacancy states of L
3
N
4
and L
3
N
5
.
A series of fifteen novel isatin oxime ether-tethered aryl 1H-1,2,3-triazole hybrids 5a–o were designed and synthesized by employing Cu(i) catalyzed azide–alkyne 3+2 cycloaddition (CuAAC) between ...isatin oxime O-propargyl ether and aryl azides. The terminal alkyne moiety, isatin oxime O-propargyl ether 3, was synthesized by converting isatin 1 into isatin oxime 2 with subsequent O-propargylation. All the triazole hybrids are remarkably stable crystalline solids and were obtained in good yields. The compounds were well characterized by multinuclear NMR spectroscopy (1H, 13C and 19F), LCMS (ESI) and elemental analysis. The structure of compounds 3 and 5a was unambiguously established by means of multiplicity edited HSQC, NOE, 1H–13C HMBC, and 1H–15N HMBC NMR studies. The newly synthesized compounds have been screened for their in vitro antitubercular activity against M. tuberculosis H37Rv (ATCC 27294 strain). Among these compounds, eight compounds have shown good MIC (0.78–6.25 μg mL−1) values in comparison with the standard drugs. Furthermore, these potent compounds exhibited low in vitro cytotoxicity profiles against RAW 264.7 cell lines. The drug-likeness profile of the promising compounds 5d (MIC 0.78 μg mL−1), 5e (MIC 1.56 μg mL−1), 5h (MIC 1.56 μg mL−1), and 5i (MIC 3.125 μg mL−1) with selectivity index (SI) >10 evaluated by the SwissADME prediction web tool indicated the compliance of these compounds with drug-likeness rules/filters, which further shows the potential of the synthesized molecules as drug candidates.
Multi component Li2O–Al2O3– ZnO–GeO2 glasses doped with CuO ranging from 0 to 1.0 mol% were prepared by the conventional melt quenching technique. Spectroscopic (optical absorption, IR, and EPR) and ...dielectric properties of the prepared glasses were examined. The EPR and optical absorption studies indicate that low-concentration CuO samples contain both Cu2+ and Cu + ions. CuO concentrations up to 0.6 mol% increased the level of disorder in the glass network, as indicated by IR studies. The dielectric study reveals the influence of copper valance states on the structural aspect of the samples. It has been shown from all these studies that the copper ions can be present in Cu3+ state in these glasses as well as Cu2+ and Cu+ states and thus participate in glass network formation. A quantitative analysis of the dielectric properties of the glasses has indicated that when the CuO concentration exceeds 0.6 mol%, the insulating strength increases. As a result, aluminum ions have been found to be tetrahedrally coordinated instead of octahedral. CuO concentrations above 0.6 mol% in the glass matrix significantly alter the physical properties of these glasses. The reduction of Cu2+ ions to Cu + ions has significantly effected the spectroscopic and dielectric investigations.
•A series of Li2O–Al2O3– ZnO–GeO2: CuO glasses have been synthesized.•A variety of dielectric and spectroscopic properties have been investigated.•Analysis of the results indicated that glasses with below 0.6 mol% CuO are good conducting materials.
Polycrystalline Cu2ZnSnSe4 (CZTSe) thin films were prepared by a two-stage process namely thermal evaporation of stacked layers Cu/ZnSe/Sn/Se on soda-lime glass substrates held at different substrate ...temperatures (Ts) in the range 523–723K followed by annealing the stack in selenium atmosphere at 723K for an hour. The effect of Ts on the growth and properties of these films were analyzed by studying their structural, microstructural and optical properties. XRD studies revealed the structure to be kesterite with a=0.569nm and c=1.139nm. Raman spectroscopy is used as a complimentary tool to know the presence of possible secondary phases. The crystallinity of the films improved with increase in the substrate temperature. Spectral transmittance studies of these films revealed two optical transitions with direct band gaps of ∼1.0eV and 1.4eV which are attributed to CZTSe and CZTSe with minor ZnSe, as the annealed stack might be inhomogeneous.
•Growth of CZTSe films by annealing thermal evaporated stacked layers Cu/ZnSe/Sn/Se.•ZnSe as precursor layer instead of Zn layer to minimize re-evaporation losses.•Optical absorption studies.
Diabetic cardiomyopathy is a common complication in patients with diabetes and is associated with underlying chronic inflammation and cardiac cell death, subsequently leading to heart failure (HF). ...ELAV-like protein 1 (ELAVL1) plays a critical role in the progression of inflammation and HF. However the role of ELAVL-1 in inflammation induced cardiac cell death (pyroptosis) under hyperglycemic condition remains elusive. Our data demonstrates that ELAVL1 expression augmented with a concomitant increase in caspase-1 and IL-1 beta expression in human hearts and human ventricular cardiomyocytes under hyperglycemic condition. Furthermore, ELAVL1 knockdown abrogates TNF-α induced canonical pyroptosis via NLRP3, caspase-1 and IL-1beta suppression. Bioinformatics analysis and target validation assays showed that miR-9 directly targets ELAVL1. Interestingly, miRNA-9 expression significantly reduced in high glucose treated cardiomyocytes and in human diabetic hearts. Inhibition of miR-9 upregulates ELAVL1 expression and activates caspase-1. Alternatively, treatment with miR-9 mimics attenuates hyperglycemia-induced ELAVL1 and inhibits cardiomyocyte pyroptosis. Taken together our study highlights the potential therapeutic implications of targeting miR-9/ELAVL1 in preventing cardiomyocyte cell loss during HF in diabetics.
Schematic representation that illustrate high glucose induced cardiac pyroptosis and regulatory role of ELAVL1 and miR-9. Display omitted
•Human diabetic heart shows increased ELAVL1, pyroptosis and decreased miR-9.•Human cardiomyocytes exposed to HG show similar changes.•KD of ELAVL1 impairs canonical inflammatory pathway associated pyroptosis.•miR-9 directly targets ELAVL1.•miR-9 mimic transfection or ELAVL1 knockdown inhibits pyroptosis.
Cu
2
ZnSnS
4
(CZTS) a quaternary semiconductor is potential candidate for absorber layer in thin-film heterojunction solar cell. Achieving CZTS thin films is really a challenging task using chemical ...methods. In this work, an attempt is made by mixing binary and ternary compound semiconducting films for the growth of CZTS films. Initially, ZnS thin films have been deposited by spray pyrolysis technique onto soda-lime glass substrates held at a substrate temperature of 698 K. Later, copper tin sulfide (Cu
2
SnS
3
CTS), a ternary compound semiconducting film, has been deposited using spray pyrolysis technique onto ZnS-coated substrates held at a substrate temperature 598 K. For achieving CZTS films, ZnS/CTS films were annealed in sulfur ambiance at different annealing temperatures in a two-zone tubular quartz furnace. The structural, optical, electrical, and surface morphological studies are carried out for these thin films.
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