Background
The body index body mass, body mass index (BMI), waist circumference and waist–height ratio and functional fitness (aerobic capacity, muscular strength, balance, flexibility and functional ...ability) of people with Down syndrome (DS) are substantially lower than those in the general population, as DS has an overall negative impact on health.
Aims
This study explored the effect of a 24‐week basketball training programme on the body composition and functional fitness of adults with DS.
Methods and procedure outcomes
Twenty‐two adults with DS (24 ± 6 years; 25 ± 4 kg/m2) were randomly allocated to the experimental (n = 11, 67.04 kg) and control groups (n = 11, 69.36 kg). The experimental group performed 24 weeks of basketball programme training (3 times per week, 60 min per session), while the control group maintained their daily activities without any special physical training. Body composition and functional fitness parameters were measured before and after the intervention. To evaluate the differences between groups, an analysis of covariance (ANCOVA) was used while controlling for differences at baseline.
Results
Hip circumference and waist–height ratio were statistically different at baseline between the intervention and control groups. After the 24‐week basketball training programme, the results showed significant differences between the exercise and control groups for hip circumference, body mass, BMI, waist circumference, hip circumference, waist–height ratio, flexibility, aerobic capacity, static and dynamic balance, balance and basketball functional ability (P < 0.05). The exercise group showed significant improvements in all variables of body composition and functional fitness (P < 0.05) except for the waist–hip ratio. There was no statistical significance between all physical composition and functional health variables in the control group except for the standing long jump (P > 0.05), with effect sizes ranging from small to large.
Conclusions and implications
The basketball training programme improved body composition and functional fitness of adults with DS.
Orbital-driven nematicity in FeSe Baek, S-H; Efremov, D V; Ok, J M ...
Nature materials,
02/2015, Letnik:
14, Številka:
2
Journal Article
Recenzirano
Odprti dostop
A fundamental and unconventional characteristic of superconductivity in iron-based materials is that it occurs in the vicinity of two other instabilities. In addition to a tendency towards magnetic ...order, these Fe-based systems have a propensity for nematic ordering: a lowering of the rotational symmetry while time-reversal invariance is preserved. Setting the stage for superconductivity, it is heavily debated whether the nematic symmetry breaking is driven by lattice, orbital or spin degrees of freedom. Here, we report a very clear splitting of NMR resonance lines in FeSe at Tnem = 91 K, far above the superconducting Tc of 9.3 K. The splitting occurs for magnetic fields perpendicular to the Fe planes and has the temperature dependence of a Landau-type order parameter. Spin-lattice relaxation rates are not affected at Tnem, which unequivocally establishes orbital degrees of freedom as driving the nematic order. We demonstrate that superconductivity competes with the emerging nematicity.
Summary
We evaluated the relationship between sagittal spinopelvic parameters and the occurrence of adjacent vertebral fractures (AVF) and determined the possible risk factor. The most important ...factors for AVFs are the degree of osteoporosis and altered biomechanics due to the spinopelvic imbalance in the fractured area of the spine.
Introduction
We intend to evaluate the relationship between sagittal spinopelvic parameters and the occurrence of adjacent vertebral fractures following the initial compression fracture and to determine the possible dominant risk factor associated with new compression fractures.
Methods
From March 2010 to May 2012, 240 consecutive patients with painful vertebral compression fractures (VCFs) were enrolled in a retrospective study. Ninety-one patients with VCFs underwent percutaneous vertebroplasty (VP) at 112 levels. The sagittal vertical axis (SVA), thoracic kyphosis (TK), lumbar lordosis (LL), sacral slope (SS), pelvic tilt (PT), pelvic incidence (PI), and segmental kyphotic angle on sagittal standing radiographs were used to evaluate radiologic outcomes.
Results
In 2 years, 15 out of 134 patients (11.1 %) treated with conservative treatment, and 12 out of 91 patients (13.1 %) treated with VP sustained adjacent level fracture. More patients with the BMD higher or equal to 3.0 experienced a new fracture than those with a BMD less than 3.0 (
p
= 0.019), and the risk for adjacent level fractures decreased significantly when segmental kyphotic angle was less than 11° (
p
= 0.001), SVA was less than 6 cm (
p
= 0.001), SS was higher or equal to 25° (
p
= 0.004), and LL was higher or equal to 25° (
p
= 0.020).
Conclusions
The most important factors for new VCFs after the initial compression fractures are the degree of osteoporosis and altered biomechanics due to the spinopelvic imbalance in the fractured area of the spine. Regarding the spinopelvic alignment to investigate the relationship with a subsequent AVF, segmental kyphotic angle, SS, LL, and SVA may be a potential predictor.
Giant Piezoelectricity on Si for Hyperactive MEMS Baek, S. H.; Park, J.; Kim, D. M. ...
Science (American Association for the Advancement of Science),
11/2011, Letnik:
334, Številka:
6058
Journal Article
Recenzirano
Microelectromechanical systems (MEMS) incorporating active piezoelectric layers offer integrated actuation, sensing, and transduction. The broad implementation of such active MEMS has long been ...constrained by the inability to integrate materials with giant piezoelectric response, such as Pb(MG 1/3 Nb 2/3 )O₃-PbTiO₃ (PMN-PT). We synthesized high-quality PMN-PT epitaxial thin films on vicinal (001) Si wafers with the use of an epitaxial (001) SrTiO₃ template layer with superior piezoelectric coefficients (e 31,f = -27 ± 3 coulombs per square meter) and figures of merit for piezoelectric energy-harvesting systems. We have incorporated these heterostructures into microcantilevers that are actuated with extremely low drive voltage due to thin-film piezoelectric properties that rival bulk PMN-PT single crystals. These epitaxial heterostructures exhibit very large electromechanical coupling for ultrasound medical imaging, microfluidic control, mechanical sensing, and energy harvesting.
Multiferroics, where (anti-) ferromagnetic, ferroelectric and ferroelastic order parameters coexist, enable manipulation of magnetic ordering by an electric field through switching of the electric ...polarization. It has been shown that realization of magnetoelectric coupling in a single-phase multiferroic such as BiFeO3 requires ferroelastic (71 , 109 ) rather than ferroelectric (180 ) domain switching. However, the control of such ferroelastic switching in a single-phase system has been a significant challenge as elastic interactions tend to destabilize small switched volumes, resulting in subsequent ferroelastic back-switching at zero electric field, and thus the disappearance of non-volatile information storage. Guided by our phase-field simulations, here we report an approach to stabilize ferroelastic switching by eliminating the stress-induced instability responsible for back-switching using isolated monodomain BiFeO3 islands. This work demonstrates a critical step to control and use non-volatile magnetoelectric coupling at the nanoscale. Beyond magnetoelectric coupling, it provides a framework for exploring a route to control multiple order parameters coupled to ferroelastic order in other low-symmetry materials.
Obesity is a major health problem associated with high morbidity and mortality. NSAID-activated gene (NAG-1) is a TGF-β superfamily member reported to alter adipose tissue levels in mice. We ...investigated whether hNAG-1 acts as a regulator of adiposity and energy metabolism.
hNAG-1 mice, ubiquitously expressing hNAG-1, were placed on a control or high-fat diet for 12 weeks. hNAG-1-expressing B16/F10 melanoma cells were used in a xenograft model to deliver hNAG-1 to obese C57BL/6 mice.
As compared with wild-type littermates, transgenic hNAG-1 mice have less white fat and brown fat despite equivalent food intake, improved glucose tolerance, lower insulin levels and are resistant to dietary- and genetic-induced obesity. hNAG-1 mice are more metabolically active with higher energy expenditure. Obese C57BL/6 mice treated with hNAG-1-expressing xenografts show decreases in adipose tissue and serum insulin levels. hNAG-1 mice and obese mice treated with hNAG-1-expressing xenografts show increased thermogenic gene expression (UCP1, PGC1α, ECH1, Cox8b, Dio2, Cyc1, PGC1β, PPARα, Elvol3) in brown adipose tissue (BAT) and increased expression of lipolytic genes (Adrb3, ATGL, HSL) in both white adipose tissue (WAT) and BAT, consistent with higher energy metabolism.
hNAG-1 modulates metabolic activity by increasing the expression of key thermogenic and lipolytic genes in BAT and WAT. hNAG-1 appears to be a novel therapeutic target in preventing and treating obesity and insulin resistance.
A
bstract
While the properties of the observed Higgs boson agree with the Standard Model predictions, the hierarchy of fermion masses lacks an explanation within the model. In this work, we consider ...a fresh approach to this problem, involving a different Higgs doublet responsible for each quark mass. We construct a model with a gauged, non-anomalous U(1) family symmetry that fixes which fermion couples to which doublet with an
O
(1) Yukawa coupling. The hierarchy of masses is generated by the hierarchy of vacuum expectation values of the Higgs fields. The model generically predicts a light, weakly coupled pseudoscalar. We verify that the model satisfies constraints from flavour changing neutral currents, Higgs phenomenology and electroweak precision tests.
The formation of two-dimensional electron gases (2DEGs) at complex oxide interfaces is directly influenced by the oxide electronic properties. We investigated how local electron correlations control ...the 2DEG by inserting a single atomic layer of a rare-earth oxide (RO) (R is lanthanum (La), praseodymium (Pr), neodymium (Nd), samarium (Sm), or yttrium (Y) into an epitaxial strontium titanate oxide (SrTiO₃) matrix using pulsed-laser deposition with atomic layer control. We find that structures with La, Pr, and Nd ions result in conducting 2DEGs at the inserted layer, whereas the structures with Sm or Y ions are insulating. Our local spectroscopic and theoretical results indicate that the interfacial conductivity is dependent on electronic correlations that decay spatially into the SrTiO₃ matrix. Such correlation effects can lead to new functionalities in designed heterostructures.
Objective
To investigate the accuracy of artificial intelligence‐assisted growth prediction using a convolutional neural network (CNN) algorithm and longitudinal lateral cephalograms (Lat‐cephs).
...Materials and Methods
A total of 198 Japanese preadolescent children, who had skeletal Class I malocclusion and whose Lat‐cephs were available at age 8 years (T0) and 10 years (T1), were allocated into the training, validation, and test phases (n = 161, n = 17, n = 20). Orthodontists and the CNN model identified 28 hard‐tissue landmarks (HTL) and 19 soft‐tissue landmarks (STL). The mean prediction error values were defined as ‘excellent,’ ‘very good,’ ‘good,’ ‘acceptable,’ and ‘unsatisfactory’ (criteria: 0.5 mm, 1.0 mm, 1.5 mm, and 2.0 mm, respectively). The degree of accurate prediction percentage (APP) was defined as ‘very high,’ ‘high,’ ‘medium,’ and ‘low’ (criteria: 90%, 70%, and 50%, respectively) according to the percentage of subjects that showed the error range within 1.5 mm.
Results
All HTLs showed acceptable‐to‐excellent mean PE values, while the STLs Pog’, Gn’, and Me’ showed unsatisfactory values, and the rest showed good‐to‐acceptable values. Regarding the degree of APP, HTLs Ba, ramus posterior, Pm, Pog, B‐point, Me, and mandibular first molar root apex exhibited low APPs. The STLs labrale superius, lower embrasure, lower lip, point of lower profile, B′, Pog,’ Gn’ and Me’ also exhibited low APPs. The remainder of HTLs and STLs showed medium‐to‐very high APPs.
Conclusion
Despite the possibility of using the CNN model to predict growth, further studies are needed to improve the prediction accuracy in HTLs and STLs of the chin area.
Maturation of canonical microRNA (miRNA) is initiated by DROSHA that cleaves the primary transcript (pri-miRNA). More than 1,800 miRNA loci are annotated in humans, but it remains largely unknown ...whether and at which sites pri-miRNAs are cleaved by DROSHA. Here, we performed in vitro processing on a full set of human pri-miRNAs (miRBase version 21) followed by sequencing. This comprehensive profiling enabled us to classify miRNAs on the basis of DROSHA dependence and map their cleavage sites with respective processing efficiency measures. Only 758 pri-miRNAs are confidently processed by DROSHA, while the majority may be non-canonical or false entries. Analyses of the DROSHA-dependent pri-miRNAs show key cis-elements for processing. We observe widespread alternative processing and unproductive cleavage events such as “nick” or “inverse” processing. SRSF3 is a broad-acting auxiliary factor modulating alternative processing and suppressing unproductive processing. The profiling data and methods developed in this study will allow systematic analyses of miRNA regulation.
Display omitted
•This study provides a quantitative map of 1,816 human pri-miRNA processing sites•Only 758 are confidently processed, while the majority are non-canonical or false entries•We uncover atypical events such as alternative, nick, and inverse processing•SRSF3 is a broad-acting cofactor modulating the majority of canonical pri-miRNAs
More than 1,800 human miRNAs have been annotated, yet it remains unknown how many are authentic and canonical miRNAs. Kim et al. perform high-throughput in vitro processing to provide the first quantitative map of primary miRNA processing sites, which reveals their DROSHA dependence and enables miRNA classification.
PDF
