Quantitative relationships between molecular structure and methionine aminopeptidase-2 inhibitory activity of a series of cytotoxic anthranilic acid sulfonamide derivatives were discovered. We have ...demonstrated the detailed application of two efficient nonlinear methods for evaluation of quantitative structure–activity relationships of the studied compounds. Components produced by principal component analysis as input of developed nonlinear models were used. The performance of the developed models namely PC-GRNN and PC-LS-SVM were tested by several validation methods. The resulted PC-LS-SVM model had a high statistical quality (
R
2
=
0.91
and
R
CV
2
=
0.81
) for predicting the cytotoxic activity of the compounds. Comparison between predictability of PC-GRNN and PC-LS-SVM indicates that later method has higher ability to predict the activity of the studied molecules.
PC-GRNN and PC-LS-SVM as regression methods were investigated for building quantitative structure–activity relationships for the prediction of inhibitory activity of methionine aminopeptidase-2 antagonists.
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Background and objectives: Vaginitis is one of the most common diseases in women. Oak gall and ajwain have been used in traditional Persian medicine for treatment of vaginitis. The purpose of this ...study was to formulate a vaginal preparation containing oak gall and ajwain and evaluate its effectiveness on the recovery and recurrence of vaginitis. Methods: The present pilot study is a randomized, double-blind clinical trial performed on 24 women with mixed vaginitis, including bacterial vaginitis and trichomoniasis in a gynecology center. Subjects were divided into two groups receiving herbal vaginal tablets or metronidazole vaginal tablets for 7 days. The vaginal tablets were prepared using dried extract of oak gall and essential oil from ajwain by direct compression method. Clinical signs and laboratory tests were assessed after treatment. The symptoms were evaluated on day 10, and also 4 and 12 weeks after intervention. Results: There was a statistically significant difference in sexual function, and characteristics of secretions including amount, pH, odor, leukocyte count and parasite content in both groups of herbal (oak gall and ajwain) and metronidazole vaginal tablets before and after treatment (p<0.05). The group receiving herbal vaginal tablets showed significantly reduced secretion at follow-up on day 10 and after 4 weeks (p<0.05).Conclusion: In our pilot study, herbal vaginal tablets containing oak gall and ajwain were as effective as metronidazole vaginal tablet. The results provide a good basis for future confirmatory tests.
Polycystic ovary syndrome (PCOS) is known as the most common hormonal disorder in women at reproductive age. Recent studies have revealed a high prevalence of sleep disorders in PCOS, suggesting that ...it is an amendable factor for these patients; however, the sleep was not considered in their treatment plan. According to the Iranian traditional medicine (ITM), sleep is an important item in the lifestyle modification of all diseases. The aim of this study is to determine the importance of sleep hygiene in PCOS from the view of ITM and Modern Medicine. In this study, some keywords about "sleep and PCOS" were searched in medical databases and some ITM books. Lifestyle modification is one of the first steps in treatment of patients with PCOS in which the emphasis will be mainly on exercise and diet. Despite proof of the high prevalence of sleep disorders in these patients, modification of sleep is not considered in their lifestyle. ITM as a holistic medicine emphasizes on lifestyle modification under the title of "Settah-e-Zaruria" (In Persian), the six essential schemes for the prevention and treatment of all diseases. Management of sleep is one of these schemes. There are many advices about sleep hygiene in both ITM and modern medicine. It seems that lifestyle modification should be expanded in PCOS patients to include more options, and sleep hygiene should be considered in their lifestyle alongside food and exercise.
Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Complementary medicine with a comprehensive and holistic approach in ...treating the diseases has become more popular in many countries. Since ancient times, leech therapy has been used to treat many diseases in Iranian traditional medicine. The present study was conducted with aim to review Iranian traditional medicine about leech therapy in polycystic ovary syndrome. Methods: In this review study, the issues related to polycystic ovary syndrome and leech therapy were studied in Iranian traditional medicine sources such as Qanun, kholasat al-hekmeh, Exir-e-aazam and Mofarrah al-gholub. Then, searching was performed in databases of PubMed, Google Scholar, Scopus, SID, and Magiran using the keywords such as “leech”, “leech therapy”, “Hirudo medicinalis”, “Hirudins” with “polycystic ovary syndrome”, “uterus”, and “oligoamenorrhea”. The review papers and clinical trial studies were searched in Persian and English languages without any time limitation, and the related materials were extracted and categorized. Results: The symptoms of PCOS such as the enlargement and stiffness of the ovaries and oligoamenorrhea were reported in ITM references entitled as “Ehtebas tams”. Leech therapy is useful in treatment of these patients by reducing the ovarian swelling, causing menstruation, eliminating waste material, as well as antioxidant and anti-inflammatory effects. Conclusion: Leech therapy can be used as a complementary treatment in patients with polycystic ovarian syndrome.
Introduction: Polycystic ovary syndrome (PCOS) is the most common cause of oligomenorrhea and anovulation in women referring with infertility. The present study was performed aimed to investigate the ...effect of combined administration of Onsoli syrup and Samgh capsule on clinical and laboratory symptoms in women with PCOS. Methods: This pilot study is a pre-and post-clinical study without control group which was performed in 2019 on 20 women aged 17-45 years with PCOS complaining of oligomenorrhea in Persian Medicine Clinic of Shahid Beheshti University of Medical Sciences. Samgh capsule and Tonic Onsoli syrup were used for two months. Anthropometric indexes, endometrial thickness, ovarian size, hormonal evaluation, number of menstruation per month, menstrual duration, and volume of menstruation bleeding were evaluated and compared at the beginning and end of the study. Data were analyzed by SPSS software (version 23) and paired t-test and Wilcoxon test. P<0.05 was considered statistically significant. Results: There was no significant difference in body mass index, body fat mass, waist to hip ratio, endometrial thickness, left ovarian size, FSH, LH before and after treatment (p>0.05). The size of the right ovary and testosterone levels significantly deceased after treatment (p=0.02). The number of menstruation per month significantly increased from 0.35±0.18 to 0.92±18 (p=0.00). Also, the duration of menstruation significantly decreased from 7.53±2.43 days to 4.05±3.17 days (p=0.00). The volume of mensuration bleeding decreased from 33.40±15.28 ml to 31.07±10.05 ml, which was not significant (p=0.368). Conclusion: Due to the effectiveness of combined administration of Persian medicine products (Onsoli syrup and Samgh capsule), it seems that the use of these products is effective in controlling of the symptoms of PCOS. It is necessary to conduct future studies with a larger sample size and longer evaluation time.
Introduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine ...products can be effective in treatment of this syndrome. This study was performed with aim to evaluate the effect of compound honey syrup on the polycystic ovary syndrome induced by estradiol valerate in female rats. Methods: In this experimental study conducted by traditional medicine and matria medica research center of Shahid Beheshti University of Medical Sciences in animal laboratory of Shahid Beheshti University of Medical Sciences on female rats in 2017, the compound honey syrup (Ma-ol-asal) (containing honey, cinnamon, ginger, saffron, cardamom, galangal, nutmeg, mace and mastic) was used. Thirty female rats were classified into five groups of cases: negative control, positive control, and three treatment groups (receiving two doses of compound honey syrup (1ml/kg and 2ml/kg) and metformin). Polycystic ovary syndrome was induced by injection of Estradiol valerate. At the end of intervention, the rats were euthanized, hormones were measured, and the ovarian histology was examined. Data were analyzed by SPSS software (version 24) and Kruskal-Wallis and Dunn-Bonferroni tests. p < 0.05 was considered statistically significant. Results: At the end of the study, weights of ovaries in the metformin and Ma-ol-asal 2 groups were higher than the untreated group. There was no change in body weight or abdominal fat. There was a significant increase in levels of progesterone in three treatment groups (P=0.002) and significant reduction of estrogen in the metformin group compared to the untreated group (P=0.021). There was significant reduction of number of ovary cysts in Ma-ol-asal 1 group (P=0.001), and significant increase in the number of Corpus luteum, and antral follicles in Ma-ol-asal 1 and 2 groups compared to the untreated group (P=0.010). The number of graph follicles did not differ significantly in the groups (P=0.083). Conclusion: Compound honey syrup was effective in improving hormonal and histological status in polycystic ovary syndrome as much as metformin and was more effective in some cases.
Background: Oligomenorrhea is a common complaint in patients with polycystic ovary syndrome (PCOS). There are some useful medicinal recommendations such as Aslagh product (include fennel fruits, ...carrot seeds, chaste tree fruits) in Iranian traditional medicine for the treatment of oligomenorrhea in PCOS. Hence, the present investigation was designed to compare Aslagh capsule with metformin on the oligomenorrhea. Materials and Methods: One hundred fifty women aged between 18-43 years with oligomenorrhea due to PCOS were randomly divided into Aslagh, metformin, and Aslagh + metformin groups. The occurrence of menstrual bleeding was considered as the primary outcome. Menstrual cyclicity, duration, and volume of the bleeding were also evaluated. Results: Occurrence of menstrual bleeding was 87.2% in all patients, with no significant difference between the three groups (P> 0.05). Menstrual cyclicity significantly improved from baseline in Aslagh and Aslagh+ metformin groups (P=0.02). Duration of menstrual bleeding was significantly higher in Aslagh group in the first and the second menstrual bleeding cycle compared to the other two groups (P<0.05). No significant change was observed in the volume of the bleeding after the intervention in any of the three groups. The occurrence of menstrual bleeding in Aslagh group was significantly (P=0.03) higher than the other two groups in the fourth month (drug-free period). Conclusion: Aslagh capsule showed beneficial effects similar to metformin in the treatment of oligomenorrhea in PCOS women and could be suggested for use as an alternative treatment in these patients. GMJ.2019;8:e1261
Oligomenorrhea is a common complaint in patients with polycystic ovary syndrome (PCOS). There are some useful medicinal recommendations such as
product (include fennel fruits, carrot seeds, chaste ...tree fruits) in Iranian traditional medicine for the treatment of oligomenorrhea in PCOS. Hence, the present investigation was designed to compare
capsule with metformin on the oligomenorrhea.
One hundred fifty women aged between 18-43 years with oligomenorrhea due to PCOS were randomly divided into
, metformin, and
+ metformin groups. The occurrence of menstrual bleeding was considered as the primary outcome. Menstrual cyclicity, duration, and volume of the bleeding were also evaluated.
Occurrence of menstrual bleeding was 87.2% in all patients, with no significant difference between the three groups (P> 0.05). Menstrual cyclicity significantly improved from baseline in
and
+ metformin groups (P=0.02). Duration of menstrual bleeding was significantly higher in
group in the first and the second menstrual bleeding cycle compared to the other two groups (P<0.05). No significant change was observed in the volume of the bleeding after the intervention in any of the three groups. The occurrence of menstrual bleeding in
group was significantly (P=0.03) higher than the other two groups in the fourth month (drug-free period).
capsule showed beneficial effects similar to metformin in the treatment of oligomenorrhea in PCOS women and could be suggested for use as an alternative treatment in these patients.
Introduction: Leucorrhea that was mentioned as Sayalan-e Rahem in Iranian traditional medicine is of the most common complains of women referring to gynecologic clinics. In Persian medicine, ...different treatment steps are proposed for these patients that nutritional recommendation is the first step in this regard. This study was performed with aim to summarize and present the nutritional guidelines in Sayalan-e Rahem from various sources so that it can be used to reduce recurrence and the incidence of drug complications. Methods: In this review study, during several meetings of authors and reviewing the most popular sources of traditional Iranian medicine, the topics related to nutritional guidelines in uterine discharge were collected and classified. Also, nutritional recommendations for uterine discharges in different conventional medicine books and the studies in different journals were extracted and then compared. Results: Based on Iranian Physician's point of view, some types of food have been generally recommended for patients with Sayalan-e Rahem that among them, we can mention astringent (Barberry, Lentils, Sumac and Mung bean( and tonic foods (apple and quince(. Sourness, garlic, onion, turnip, cow meat and flatulent foods have been generally avoided in patients with Sayalan-e Rahem. If Sayalan-e Rahem be due to imbalance of four different humors in the body, appropriate diet will be advised for each distemperament. Conclusion: Considering lack of enough nutritional recommendation in conventional medicine for patients with leucorrhea, so attention to the mentioned above and performing scientifically evaluations on the effect of recommended food in Sayalan-e Rahem can be effective on enhancing health and life quality of women.
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