Devices that exploit the quantum properties of materials are widespread, with quantum information processors and quantum sensors showing significant progress. Organic materials offer interesting ...opportunities for quantum technologies owing to their engineerable spin properties, with spintronic operation and spin resonance magnetic‐field sensing demonstrated in research grade devices, as well as proven compatibility with large‐scale fabrication techniques. Yet several important challenges remain as moving toward scaling these proof‐of‐principle quantum devices to larger integrated logic systems or spatially smaller sensing elements, particularly those associated with the variation of quantum properties both within and between devices. Here, spatially resolved magnetoluminescence is used to provide the first 2D map of a hyperfine spin property—the Overhauser field—in traditional organic light‐emitting diodes (OLEDs). Intra‐device variabilities are found to exceed ≈30% while spatially correlated behavior is exhibited on lengths beyond 7 µm, similar in size to pixels in state‐of‐the‐art active‐matrix OLED arrays, which has implications for the reproducibility and integration of organic quantum devices.
The hyperfine interaction is an important spin quantum property in organic semiconductors. Exploiting the electroluminescence response of organic light‐emitting diodes to magnetic fields, large intra‐device variations of this property exceeding ≈30% are resolved which are spatially correlated over characteristic lengths of 7 µm. This has implications for the reproducibility and integration of organic devices which rely on spin for their functionality.
The Declaration of Helsinki has called for the registration of all research studies involving human participants. Despite this, prior registries did not allow registration certain study types, or ...retrospective registration. The Research Registry® (www.researchregistry.com) was established in 2015 to provide a venue of registration for any study involving human participants.
and analysis: This retrospective database analysis describes the first 3000 registrations received by the Research Registry®. Since the launch of the Registry in 2015, we have collected data on each registration and excluded inappropriate registrations through a weekly curation process. The characteristics of all studies registered is presented. Each registration was marked against a quality score by two researchers acting independently, and we describe how this has changed over time. No ethical approval was required for this data only study including no human participants.
Of 3000 registrations, we included 2645 that were submitted to the registry between February 2015 and October 2017. The number of registrations increased year on year, and we now receive between 60 and 80 registrations per month. One fifth of registrations were from China (537 20.3%). Retrospective observational studies were most commonly registered (1125 42.5%), and studies included in excess of 20 million patients (median 80 IQR:25–200). The quality score of registrations improved over the time (Kruskal-Wallis p < 0.05), and the ‘control/comparator’ component of the quality score was most poorly completed (completed by 1199 54%).
The Research Registry® has received registrations on over 2500 registrations, including in excess of 20 million patients, with the quality of registrations improving over time. Retrospective observational studies and case series are the most commonly registered.
•In excess of 20 million patients have been registered with included studies.•These studies come from 116 countries, the commonest being China.•Quality of registrations have improved over time.
Abstract The rapid development of mixed‐halide perovskites has established a versatile optoelectronic platform owing to their extraordinary physical properties, but there remain challenges toward ...achieving highly reliable synthesis and performance, in addition, post‐synthesis approaches for tuning their photoluminescence properties after device fabrication remain limited. In this work, an effective approach is reported to leveraging hot electrons generated from plasmonic nanostructures to regulate the optical properties of perovskites. A plasmonic metasurface composed of Au nanoparticles can effectively tailor both photoluminescence and location‐specific phase segregation of mixed‐halide CsPbI 2 Br thin films. The ultrafast transient absorption spectroscopy measurements reveal hot electron injection on the timescale of hundreds of femtoseconds. Photocurrent measurements confirm the hot‐electron‐enhanced photon‐carrier conversion, and in addition, gate‐voltage tuning of phase segregation is observed because of correlated carrier injection and halide migration in the perovskite films. Finally, the characteristics of the gate‐modulated light emission are found to conform to a rectified linear unit function, serving as nonlinear electrical‐to‐optical converters in artificial neural networks. Overall, the hot electron engineering approach demonstrated in this work provides effective location‐specific control of the phase and optical properties of halide perovskites, underscoring the potential of plasmonic metasurfaces for advancing perovskite technologies.
Abstract Background Research registration is an important ethical principle in the Declaration of Helsinki, however, progress to increase registration has been slow. Understanding the attitudes of ...users towards registries may provide insights into increase research registration. In this survey-based study, we sought to gain insight from users of a single global research registry, the Research Registry® ( www.researchregistry.com ). Methods A Google Forms survey was created and emailed to all users of the Research Registry® (n = 1432). Multiple choice and free-text answers were analyzed using descriptive statistics and thematic analysis respectively. Results From 925 contactable registrations, 149 (16.1%) completed the survey. The most commonly registered study type was retrospective cohort (32.2%). 23 registrations (15.4%) were made during the planning or conception of the study, whereas 67 (45.0%) registered at the time of journal submission, or during the peer review process. Of those that declared whether they had performed unregistered research or not, 51 (45.5%) participants had previously performed unregistered research. Registrants were most commonly made aware of the Research Registry® through submission to the International Journal of Surgery (IJS) family of journals (n = 57, 47.5%). Survey participants identified the most important features of registration to be its convenience, including the ease, time and cost of registration. Thematic analysis revealed the most common motive for registration to be as a mandatory requirement of journal submission, and that registration can be improved by simplification of the registration process. Conclusion Registries must focus on engaging their network of users to ensure that research registration is a dynamic process. They need to adopt a user-centered and agile approach to their development, with a strong focus on “customer service”. Moreover, by working in partnership with journals, it is possible to improve compliance with registration.
•A meta-analysis was conducted to assess the neuropsychological impact of cannabis.•A limited association was found between chronic cannabis use and neurocognitive deficits.•Memory and chronic ...cannabis smoking were linked.
Cannabis is currently the most used illicit substance in the world with a global widespread distribution. Although its acute neurocognitive effects on human behaviour have been reported, there is a lack of robust analysis investigating the link, if any, between chronic cannabis use and neurocognitive function. A systematic review of the literature was conducted in order to identify relevant studies published from 2010 to 2019. A meta-analysis was performed on 13 selected studies testing performance of chronic cannabis users compared with non-users in six different neurocognitive domains. There was a low cross-sectional association between neurocognitive impairments and chronic cannabis use in cognitive impulsivity, cognitive flexibility, attention, short-term memory and long-term memory. No association was found between chronic cannabis use and motor impulsivity. By analysing a specific target population with strict inclusion criteria, these findings provide inconclusive evidence that there are cognitive impairments associated with chronic cannabis use. Future research is needed to determine if the findings of this meta-analysis are biased by the methodological limitations encountered.
Introduction:
The cognitive impact of opioid dependence is rarely measured systematically in everyday clinical practice even though both patients and clinicians accept that cognitive symptoms often ...occur in the opioid-dependent population. There are only a few publications which utilized computerized neuropsychological tests to assess possible impairments of visuospatial memory in opioid-dependent individuals either receiving opioid replacement therapy (ORT) or during subsequent short-term abstinence and the effects of anxiety and depression.
Methods:
We assessed a cohort of 102 participants, comprising i) a stable opioid-dependent group receiving methadone maintenance treatment (MMT) (n = 22), ii) a stable opioid-dependent group receiving buprenorphine (BMT) (n = 20), iii) a current abstinent but previously opioid-dependent group (ABS) (n = 8), and iv) a control group who have never been dependent on opioids. The Cambridge Neuropsychological Automated Test Battery (CANTAB) neuropsychological tasks undertaken by participants included: Delayed Matching to Sample (DMS), Pattern Recognition Memory (PRM), Spatial Recognition Memory (SRM), and Paired Associate Learning (PAL) tasks. Three clinical measures were used to assess the severity of anxiety and depressive illness: Hospital Anxiety Scale-Hospital Anxiety Depression (HADA)-(HADD), Beck Depression Inventory (BDI), and Inventory of Depressive Symptomatology (self-report) (ISD-SR).
Results:
The methadone- and buprenorphine-treated groups showed significant impairments (p < 0.001) in visuospatial memory tasks but not the abstinent group. Impairments in visuospatial memory strongly correlated with higher mood and anxiety symptom severity scores (p < 0.001).
Discussion:
These results are broadly consistent with previous studies. Uniquely, though, here we report a strong relationship between visuospatial memory and depression and anxiety scores, which might suggest common illness mechanisms.
With up to 40% of patients having patellofemoral joint osteoarthritis (PFJ OA), the two arthroplasty options are to replace solely the patellofemoral joint via patellofemoral arthroplasty (PFA), or ...the entire knee via total knee arthroplasty (TKA). The aim of this study was to assess postoperative success of second-generation PFAs compared to TKAs for patients treated for PFJ OA using patient-reported outcome measures (PROMs) and domains deemed important by patients following a patient and public involvement meeting.
MEDLINE, EMBASE via OVID, CINAHL, and EBSCO were searched from inception to January 2022. Any study addressing surgical treatment of primary patellofemoral joint OA using second generation PFA and TKA in patients aged above 18 years with follow-up data of 30 days were included. Studies relating to OA secondary to trauma were excluded. ROB-2 and ROBINS-I bias tools were used.
A total of nine studies were included, made up of four randomized controlled trials (domain 1) and five cohort studies (domain 2). PROMs and knee function specific scores developed for reporting TKA were unable to detect any difference between PFA and TKA. There was no significant difference in complications between PFA and TKA. PFAs were found to have a better postoperative range of motion.
TKA and PFA are both viable options for patients with primary PFJ OA. Over time, we have seen an emphasis on patient satisfaction and better quality of life. Recommending sacrificing healthy medial and lateral compartments to treat patellofemoral joint arthritis should be given further thought.
Introduction: Coronavirus disease 2019 (COVID-19) results from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). it is now a pandemic that affects us all. For patients referring to the ...addiction care systems, this pandemic can create additional vulnerabilities. A great deal of effort has made to re-organize the care systems for patients with addiction. Our study focuses on the voice of our patients, on clues to adapt treatment, and on the impact of the pandemic on the therapeutic alliance. Methods: A qualitative design was used to develop a description and understanding of general and clinically relevant aspects of the impact of the COVID-19 pandemic. Fifteen addicted patients (11 under treatment and 4 in recovery) were interviewed by 4 interviewers according to the COREQ (consolidated criteria for reporting qualitative research). Results: COVID-19 has had a serious impact on thoughts, feelings, and behaviors. Interviewees shared their anxieties about their health and the health of their relatives. Frightening thoughts were associated with a range of negative feelings and behaviors, such as stress, anger, avoidance, and isolation. The use of psychoactive substances differed between the patients in treatment with those who are in stable recovery. In the former, all succeeded in staying abstinent. They have experienced that solidarity and connectedness were essential in sustaining their recovery. Those still in treatment were fighting against the temptation to start using again; they felt emotionally isolated and sometimes patronized by health care workers. Conclusion: The elaboration of the interviewees on the therapeutic relationship provides promising clues to optimize that relationship. Remembering this common expression, “we are all in this together,” shared decision making could very well be used to shape effective and receptive treatment interventions during the different challenges faced at different stages of the COVID-19 epidemic.
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