AX J0043-737 is a source in the ASCA catalogue, the nature of which is uncertain. It is most commonly classified as a Crab-like pulsar in the Small Magellanic Cloud (SMC) following apparent detection ...of pulsations at ~ 87 ms from a single ASCA observation. A follow-up ASCA observation was not able to confirm this, and the X-ray detection of the source has not been reported since. With a dedicated XMM-Newton, observation, we studied the nature of the source. We ascertained the source position, searched for the most probable counterpart and studied the X-ray spectrum. We also analysed other archival observations with the source in the field of view to study its long-term variability. With the good position localisation capability of XMM-Newton, we identify the counterpart of the source as MQS J004241.66--734041.3, an AGN behind the SMC at a redshift of 0.95. The X-ray spectrum can be fitted with an absorbed power law with a photon-index of \(\Gamma=1.7\) which is consistent with that expected from AGNs. By comparing the current XMM-Newton, observation with an archival XMM-Newton and two other ASCA observations of the source, we find signatures of long-term variability which is also a common phenomenon in AGNs. All of the above are consistent with AX J0043-737 being an AGN behind the SMC.
Cryptosporidium parvum, Tyzzer, 1912 is identified as a common cause of diarrhoea in immunocompetent individuals. In immunocompromised, especially HIV-infected subjects, cryptosporidiosis causes ...severe chronic diarrhoea. In this study, nitazoxanide (NTZ) was compared for curative activity with sinefungin (SNF) and paromomycin (PRM) in immunosuppressed rats, a screening model for anticryptosporidial agents. NTZ at either 50 mg/kg/day, 100 mg/kg/day or 200 mg/kg/day resulted in seven days in a dose-dependent inhibition of oocyst shedding similar to that obtained with SNF (10 mg/kg/day) and PRM (100 mg/kg/day). Further discontinuation of SNF or PRM 100 mg/kg/day therapy resulted in early relapse of oocyst shedding which reached the pre-treatment levels in 2-4 days. In contrast, seven days after discontinuation of therapy, shedding inhibition was unchanged in NTZ-treated rats. Data prompt further assessment of the activity of NTZ on sequestered C. parvum.
This study deals with the realization of electronic components using regioregular poly(3-octylthiophene) (P3OT) as active layer with a view to their integration on a flexible support. We first ...describe the structure and the realization methods of our diodes, we detailed their characterization and the extraction of some parameters such as the concentration and mobility of free carriers, holes, in our structures. We then treat the fabrication of organic transistors like TFT.
Total and IgE serum antibodies to tetanus toxoid were measured in 32 healthy adults, 3-4 weeks following booster immunization with either plain or aluminum hydroxide-absorbed tetanus toxoid. Whereas ...no difference in the total antibody values was observed, the level of anti-tetanus toxoid IgE antibodies was significantly higher in the group boostered with the adjuvanted vaccine.
The highest ratio of abscesses in five-week-old Sprague-Dawley male rats was obtained with a combination of intrastromal injection of 104 trophozoites with a regimen of subconjunctival injection of ...0.28 mg/week betamethasone.
XMM-Newton has observed the X-ray sky since early 2000. The XMM-Newton Survey Science Centre Consortium has published catalogues of X-ray and ultraviolet sources found serendipitously in the ...individual observations. This series is now augmented by a catalogue dedicated to X-ray sources detected in spatially overlapping XMM-Newton observations. The aim of this catalogue is to explore repeatedly observed sky regions. It thus makes use of the long(er) effective exposure time per sky area and offers the opportunity to investigate long-term flux variability directly through the source detection process. A new standardised strategy for simultaneous source detection on multiple observations is introduced. It is coded as a new task within the XMM-Newton Science Analysis System and used to compile a catalogue of sources from 434 stacks comprising 1,789 overlapping XMM-Newton observations that entered the 3XMM-DR7 catalogue, have a low background and full-frame readout of all EPIC cameras. The first stacked catalogue is called 3XMM-DR7s. It contains 71,951 unique sources with positions and parameters such as fluxes, hardness ratios, quality estimates, and information on inter-observation variability. About 15% of the sources are new with respect to 3XMM-DR7. Through stacked source detection, the parameters of repeatedly observed sources can be determined with higher accuracy than in the individual observations. The method is more sensitive to faint sources and tends to produce fewer spurious detections. With this first stacked catalogue we demonstrate the feasibility and benefit of the approach. It supplements the large data base of XMM-Newton detections by additional, in particular faint, sources and adds variability information. In the future, the catalogue will be expanded to larger samples and continued within the series of serendipitous XMM-Newton source catalogues.
The present study concerns the interferon (IFN) compartment of the immune response in human malaria. It was undertaken with Plasmodium falciparum parasitized human red blood cell culture supernatants ...(PF-RBCS). Investigations were conducted in order to verify whether supernatants of such protozoa cultures had the capacity to induce gamma interferon previously identified in sera of P. falciparum infected patients and to verify whether a T-cell mitogen recently characterized in vitro could be correlated with the eventual IFN-inducing activity. Investigations were performed with nonsynchronized P. falciparum cultures and highly synchronized PF-RBC cycles. Results obtained with the first type of experiment demonstrated the presence of an immune interferon inductor in PF-RBCS controlled for their positive mitogenic activity. In supernatants from highly synchronized PF-RBC cycles it was possible to further correlate the mitogen activity with the capacity to induce IFN-gamma. Both activities were found in the time-interval situated near the end of the parasite cycle shortly previous of the merozoite stage. At an earlier time, at the peak of the ring stage, when no mitogen activity was detected, an interferon-induction activity, solely of IFN-alpha, was also demonstrated.
PDF
