COVID-19 pandemics has influenced many research and educational projects, and it influenced also ELLIPSE-project, aiming at the creation of a free online curriculum in suicide prevention for students ...in the higher education in Sweden, Austria, Hungary, Norway and Poland (September 2019-August 2022). The ELLIPSE (E-Lifelong Learning In Prevention of Suicide in Europe) (www.e-llipse.com) is the first international project in the area of education in suicide prevention in the higher education co-founded by the European Union Erasmus+ programme. We will reflect on some opportunities and challenges due to COVID-19 pandemics. Identified opportunities: 1) learning a new way of communicating, 2) reaching more participants (in case of Sweden we were able to get participants from more regions, 3) more frequent meetings heightening the quality of the project, 4) travelling less (online is the more eco-friendly solution). But there were also some challenges: 1) not be able to proceed according to the preliminary plan generated much more administrative work, 2) online meetings was a challenge for those partners who had problems adjusting to the online form of communication, 3) more negative attitudes to the canal of communication resulted in avoiding it, leading to less frequent interactions what resulted in diminished motivation to the project, and being unable to proceed with project tasks, 4) resignation of some patients from participation because of difficulties in accepting the online form of communication. We will discuss these issues in a more detailed way during the interactive workshop.
Disclosure
The E-Lifelong Learning In Prevention of Suicide In Europe (ELLIPSE)-project is co-funded by the European Union’s Programme Erasmus+ (Project ID: 2019-1-SE01-KA203-060571). The EU Commission’s support for this project does not mean that the Commission end
A new 5-stage cardiogenic shock (CS) classification scheme was recently proposed by the Society for Cardiovascular Angiography and Intervention (SCAI) for the purpose of risk stratification.
This ...study sought to apply the SCAI shock classification in a cardiac intensive care unit (CICU) population.
The study retrospectively analyzed Mayo Clinic CICU patients admitted between 2007 and 2015. SCAI CS stages A through E were classified retrospectively using CICU admission data based on the presence of hypotension or tachycardia, hypoperfusion, deterioration, and refractory shock. Hospital mortality in each SCAI shock stage was stratified by cardiac arrest (CA).
Among the 10,004 unique patients, 43.1% had acute coronary syndrome, 46.1% had heart failure, and 12.1% had CA. The proportion of patients in SCAI CS stages A through E was 46.0%, 30.0%, 15.7%, 7.3%, and 1.0% and unadjusted hospital mortality in these stages was 3.0%, 7.1%, 12.4%, 40.4%, and 67.0% (p < 0.001), respectively. After multivariable adjustment, each higher SCAI shock stage was associated with increased hospital mortality (adjusted odds ratio: 1.53 to 6.80; all p < 0.001) compared with SCAI shock stage A, as was CA (adjusted odds ratio: 3.99; 95% confidence interval: 3.27 to 4.86; p < 0.001). Results were consistent in the subset of patients with acute coronary syndrome or heart failure.
When assessed at the time of CICU admission, the SCAI CS classification, including presence or absence of CA, provided robust hospital mortality risk stratification. This classification system could be implemented as a clinical and research tool to identify, communicate, and predict the risk of death in patients with, and at risk for, CS.
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Fatty acid activation in thermogenic adipose tissue Steensels, Sandra; Ersoy, Baran A.
Biochimica et biophysica acta. Molecular and cell biology of lipids,
January 2019, 2019-01-00, 20190101, Letnik:
1864, Številka:
1
Journal Article
Recenzirano
Channeling carbohydrates and fatty acids to thermogenic tissues, including brown and beige adipocytes, have garnered interest as an approach for the management of obesity-related metabolic disorders. ...Mitochondrial fatty acid oxidation (β-oxidation) is crucial for the maintenance of thermogenesis. Upon cellular fatty acid uptake or following lipolysis from triglycerides (TG), fatty acids are esterified to coenzyme A (CoA) to form active acyl-CoA molecules. This enzymatic reaction is essential for their utilization in β-oxidation and thermogenesis. The activation and deactivation of fatty acids are regulated by two sets of enzymes called acyl-CoA synthetases (ACS) and acyl-CoA thioesterases (ACOT), respectively. The expression levels of ACS and ACOT family members in thermogenic tissues will determine the substrate availability for β-oxidation, and consequently the thermogenic capacity. Although the role of the majority of ACS and ACOT family members in thermogenesis remains unclear, recent proceedings link the enzymatic activities of ACS and ACOT family members to metabolic disorders and thermogenesis. Elucidating the contributions of specific ACS and ACOT family members to trafficking of fatty acids towards thermogenesis may reveal novel targets for modulating thermogenic capacity and treating metabolic disorders.
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•No significant effect of biochar amendment on soil enzymatic activity.•Soil with biochar amended is low-toxic to Vibrio fischeri.•Soil amended with biochar was not toxic to ...Heterocypris incongruens.•Biochar application did not significantly increase the biomass production of grass.
Diversity of technological conditions and of raw materials from which biochar is produced is the reason why its soil application may have a varied effect on chemical and biological properties of soil and soil ecotoxicity. The aim of this study was to evaluate the effect of the addition of poultry litter (5.00tDMha−1) and biochar obtained from this material in doses of 2.25t and 5tDMha−1 on soil enzymatic activity, soil ecotoxicity and grass crop yield (pasture grass mix). The research was carried out under field conditions. No significant effect of biochar amendment on soil enzymatic activity was observed. The biochar-amended soil was low-toxic to Vibrio fischeri and non-toxic to Heterocypris incongruens. Application of poultry litter biochar in doses of 2.25t and 5tDMha−1 contributed to an increase in plant biomass production by 32% and 30%, respectively compared to the control (C). Biochar had more adverse effect on soil enzymatic activity and grass crop yield than non-converted poultry litter, but it significantly reduced soil toxicity to H. incongruens and V. fischeri.
Planets that orbit their parent star at less than about one astronomical unit (1 AU is the Earth-Sun distance) are expected to be engulfed when the star becomes a red giant. Previous observations ...have revealed the existence of post-red-giant host stars with giant planets orbiting as close as 0.116 AU or with brown dwarf companions in tight orbits, showing that these bodies can survive engulfment. What has remained unclear is whether planets can be dragged deeper into the red-giant envelope without being disrupted and whether the evolution of the parent star itself could be affected. Here we report the presence of two nearly Earth-sized bodies orbiting the post-red-giant, hot B subdwarf star KIC 05807616 at distances of 0.0060 and 0.0076 AU, with orbital periods of 5.7625 and 8.2293 hours, respectively. These bodies probably survived deep immersion in the former red-giant envelope. They may be the dense cores of evaporated giant planets that were transported closer to the star during the engulfment and triggered the mass loss necessary for the formation of the hot B subdwarf, which might also explain how some stars of this type did not form in binary systems.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We present our analysis of simulated data in order to derive a detection threshold which can be used in the pre-whitening process of amplitude spectra. In case of ground-based data of pulsating ...stars, this threshold is conventionally taken to be four times the mean noise level in an amplitude spectrum. This threshold is questionable when space-based data are analysed. Our effort is aimed at revising this threshold in the case of continuous 90-d Kepler K2 phase observations. Our result clearly shows that a 95 per cent confidence level, common for ground observations, can be reached at 5.4 times the mean noise level and is coverage dependent. In addition, this threshold varies between 4.8 and 5.7, if the number of cadences is changed. This conclusion should secure further pre-whitening and helps to avoid over-interpretation of spectra of pulsating stars observed with the Kepler spacecraft during K2 phase. We compare our results with the standard approach widely used in the literature.
We examine 4 yr almost continuous Kepler photometry of 115 B stars. We find that the light curves of 39 per cent of these stars can be described by a low-frequency sinusoid and its harmonic, usually ...with variable amplitude, which we interpret as rotational modulation. A large fraction (32 stars or 28 per cent) might be classified as ellipsoidal variables, but a statistical argument suggests that these are probably rotational variables as well. Ten stars (8 per cent of the total) have a peculiar periodogram feature which is common among A stars. The physical cause of this feature is unknown but very likely related to rotation. The large number of rotating variables suggests that star-spots are common in B stars and indicates that magnetic fields can be generated in radiative stellar envelopes. We find five stars (4 per cent) to be β Cep (BECP) variables, all of which have low frequencies with relatively large amplitudes. The presence of low frequencies in BECP stars is an unsolved problem. There are 21 stars (18 per cent) with multiple low frequencies which could be described as slowly pulsating B (SPB) variables. Other pulsating stars do not fit into the general definition of BECP or SPB variables in that they are cool but pulsate with high frequencies. We assume that these are further examples of the anomalous pulsating stars which in the past have been called ‘Maia’ variables. There are 11 stars (10 per cent) of this type. We also examined 300 B stars observed in the K2 Campaign 0 field. We find 12 BECP/Maia candidates and 15 SPB variables.
ABSTRACT
The results of the evolutionary modelling of subdwarf B stars are presented. For the first time, we explore the core and near-core mixing in subdwarf B stars using new algorithms available ...in the mesa code: the predictive mixing scheme and the convective pre-mixing scheme. We show how both methods handle problems related to the determination of the convective boundary and the discrepancy between the core masses obtained from asteroseismology and evolutionary models, and long-standing problems related to the core-helium-burning phase, such as the splitting of the convective core and the occurrence of breathing pulses. We find that the convective pre-mixing scheme is the preferable algorithm. The masses of the convective core in the case of the predictive mixing and the combined convective and semiconvective regions in the case of the convective pre-mixing scheme are higher than in the models with only the Ledoux criterion, but they are still lower than the seismic-derived values. Both algorithms are promising and alternative methods of studying models of subdwarf B stars.
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