Emerging organic contaminants (EOCs) detected in groundwater may have adverse effects on human health and aquatic ecosystems. This paper reviews the existing occurrence data in groundwater for a ...range of EOCs including pharmaceutical, personal care, ‘life-style’ and selected industrial compounds. The main sources and pathways for organic EOCs in groundwater are reviewed, with occurrence data for EOCs in groundwater included from both targeted studies and broad reconnaissance surveys. Nanogram-microgram per litre concentrations are present in groundwater for a large range of EOCs as well as metabolites and transformation products and under certain conditions may pose a threat to freshwater bodies for decades due to relatively long groundwater residence times. In the coming decades, more of these EOCs are likely to have drinking water standards, environmental quality standards and/or groundwater threshold values defined, and therefore a better understanding of the spatial and temporal variation remains a priority.
► First review to focus on EOCs in groundwater. ► A large range (n>180) of EOCs are detected in groundwater. ► Significant concentrations (102–104ng/L) for a range of EOCs, including endocrine disruptors. ► Groundwater EOC occurrence is poorly characterised compared to other freshwater resources.
A large range of emerging organic contaminants are now being detected in groundwater as a result of recent and historical anthropogenic activities.
We present the VLA-COSMOS 3 GHz Large Project based on 384 h of observations with the Karl G. Jansky Very Large Array (VLA) at 3 GHz (10 cm) toward the two square degree Cosmic Evolution Survey ...(COSMOS) field. The final mosaic reaches a median rms of 2.3 μJy beam-1 over the two square degrees at an angular resolution of 0.75″. To fully account for the spectral shape and resolution variations across the broad (2 GHz) band, we image all data with a multiscale, multifrequency synthesis algorithm. We present a catalog of 10 830 radio sources down to 5σ, out of which 67 are combined from multiple components.Comparing the positions of our 3 GHz sources with those from the Very Long Baseline Array (VLBA)-COSMOS survey, we estimate that the astrometry is accurate to 0.01″ at the bright end (signal-to-noise ratio, S/N3 GHz > 20). Survival analysis on our data combined with the VLA-COSMOS 1.4 GHz Joint Project catalog yields an expected median radio spectral index of α = −0.7. We compute completeness corrections via Monte Carlo simulations to derive the corrected 3 GHz source counts. Our counts are in agreement with previously derived 3 GHz counts based on single-pointing (0.087 square degrees) VLA data. In summary, the VLA-COSMOS 3 GHz Large Project simultaneously provides the largest and deepest radio continuum survey at high (0.75″) angular resolution to date, bridging the gap between last-generation and next-generation surveys.
We examine the behaviour of the infrared-radio correlation (IRRC) over the range 0 <z ≲ 6 using new, highly sensitive 3 GHz observations with the Karl G. Jansky Very Large Array (VLA) and infrared ...data from the Herschel Space Observatory in the 2 deg2 COSMOS field. We distinguish between objects where emission is believed to arise solely from star-formation, and those where an active galactic nucleus (AGN) is thought to be present. We account for non-detections in the radio or in the infrared using a doubly-censored survival analysis. We find that the IRRC of star-forming galaxies, quantified by the infrared-to-1.4 GHz radio luminosity ratio (qTIR), decreases with increasing redshift: qTIR(z) = (2.88 ± 0.03)(1 + z)− 0.19 ± 0.01. This is consistent with several previous results from the literature. Moderate-to-high radiative luminosity AGN do not follow the same qTIR(z) trend as star-forming galaxies, having a lower normalisation and steeper decrease with redshift. We cannot rule out the possibility that unidentified AGN contributions only to the radio regime may be steepening the observed qTIR(z) trend of the star-forming galaxy population. We demonstrate that the choice of the average radio spectral index directly affects the normalisation, as well as the derived trend with redshift of the IRRC. An increasing fractional contribution to the observed 3 GHz flux by free-free emission of star-forming galaxies may also affect the derived evolution. However, we find that the standard (M82-based) assumption of the typical radio spectral energy distribution (SED) for star-forming galaxies is inconsistent with our results. This suggests a more complex shape of the typical radio SED for star-forming galaxies, and that imperfect K corrections in the radio may govern the derived trend of decreasing qTIR with increasing redshift. A more detailed understanding of the radio spectrum is therefore required for robust K corrections in the radio and to fully understand the cosmic evolution of the IRRC. Lastly, we present a redshift-dependent relation between rest-frame 1.4 GHz radio luminosity and star formation rate taking the derived redshift trend into account.
We study the composition of the faint radio population selected from the Karl G. Jansky Very Large Array Cosmic Evolution Survey (VLA-COSMOS) 3 GHz Large Project, which is a radio continuum survey ...performed at 10 cm wavelength. The survey covers a 2.6 square degree area with a mean rms of ~ 2.3 μJy/beam, cataloging 10 830 sources above 5σ, and enclosing the full 2 square degree COSMOS field. By combining these radio data with optical, near-infrared (UltraVISTA), and mid-infrared (Spitzer/IRAC) data, as well as X-ray data (Chandra), we find counterparts to radio sources for ~93% of the total radio sample reaching out to z ≲ 6; these sources are found in the unmasked areas of the COSMOS field, i.e., those not affected by saturated or bright sources in the optical to near-infrared (NIR) bands. We further classify the sources as star-forming galaxies or AGN based on various criteria, such as X-ray luminosity; observed mid-infrared color; UV–far-infrared spectral energy distribution; rest-frame, near-UV optical color that is corrected for dust extinction; and radio excess relative to that expected from the star formation rate of the hosts. We separate the AGN into subsamples dominated by low-to-moderate and moderate-to-high radiative luminosity AGN, i.e., candidates for high-redshift analogs to local low- and high-excitation emission line AGN, respectively. We study the fractional contributions of these subpopulations down to radio flux levels of ~11 μJy at 3 GHz (or ~20 μJy at 1.4 GHz assuming a spectral index of –0.7). We find that the dominant fraction at 1.4 GHz flux densities above ~200 μJy is constituted of low-to-moderate radiative luminosity AGN. Below densities of ~100 μJy the fraction of star-forming galaxies increases to ~ 60%, followed by the moderate-to-high radiative luminosity AGN (~ 20%) and low-to-moderate radiative luminosity AGN (~ 20%). Based on this observational evidence, we extrapolate the fractions down to sensitivities of the Square Kilometer Array (SKA). Our estimates suggest that at the faint flux limits to be reached by the (Wide, Deep, and UltraDeep) SKA1 surveys, a selection based only on radio flux limits can provide a simple tool to efficiently identify samples highly (>75%) dominated by star-forming galaxies.
We explore the multiwavelength properties of AGN host galaxies for different classes of radio-selected AGN out to z ≲ 6 via a multiwavelength analysis of about 7700 radio sources in the COSMOS field. ...The sources were selected with the Very Large Array (VLA) at 3 GHz (10 cm) within the VLA–COSMOS 3 GHz Large Project, and cross-matched with multiwavelength ancillary data. This is the largest sample of high-redshift (z ≲ 6) radio sources with exquisite photometric coverage and redshift measurements available. We constructed a sample of moderate-to-high radiative luminosity AGN (HLAGN) via spectral energy distribution decomposition combined with standard X-ray and mid-infrared diagnostics. Within the remainder of the sample we further identified low-to-moderate radiative luminosity AGN (MLAGN) via excess in radio emission relative to the star formation rates in their host galaxies. We show that at each redshift our HLAGN havesystematically higher radiative luminosities than MLAGN and that their AGN power occurs predominantly in radiative form, while MLAGN display a substantial mechanical AGN luminosity component. We found significant differences in the host properties of the two AGN classes, as a function of redshift. At z< 1.5, MLAGN appear to reside in significantly more massive and less star-forming galaxies compared to HLAGN. At z> 1.5, we observed a reversal in the behaviour of the stellar mass distributions with the HLAGN populating the higher stellar mass tail. We interpret this finding as a possible hint of the downsizing of galaxies hosting HLAGN, with the most massive galaxies triggering AGN activity earlier than less massive galaxies, and then fading to MLAGN at lower redshifts. Our conclusion is that HLAGN and MLAGN samples trace two distinct galaxy and AGN populations in a wide range of redshifts, possibly resembling the radio AGN types often referred to as radiative- and jet-mode (or high- and low-excitation), respectively, whose properties might depend on the different availability of cold gas supplies.
The Chalk aquifer of Northern Europe is an internationally important source of drinking water and sustains baseflow for surface water ecosystems. The areal distribution of microorganic (MO) ...contaminants, particularly non-regulated emerging MOs, in this aquifer is poorly understood. This study presents results from a reconnaissance survey of MOs in Chalk groundwater, including pharmaceuticals, personal care products and pesticides and their transformation products, conducted across the major Chalk aquifers of England and France. Data from a total of 345 sites collected during 2011 were included in this study to provide a representative baseline assessment of MO occurrence in groundwater. A suite of 42 MOs were analysed for at each site including industrial compounds (n=16), pesticides (n=14) and pharmaceuticals, personal care and lifestyle products (n=12). Occurrence data is evaluated in relation to land use, aquifer exposure, well depth and depth to groundwater to provide an understanding of vulnerable groundwater settings.
•Broad range of microorganics detected in Chalk groundwater in England and France.•Plasticisers, pesticides, BPA and THM detected at the highest concentrations.•Pesticides higher in outcrop Chalk, caffeine and BPA at concealed sites.•Occurrences show some relationship to land use, borehole depth and water level.
Broad screening reveals for the first time the extent of emerging microorganic pollution in Chalk groundwater sources across England and France.
We make use of the deep Karl G. Jansky Very Large Array (VLA) COSMOS radio observations at 3 GHz to infer radio luminosity functions of star-forming galaxies up to redshifts of z ~ 5 based on ...approximately 6000 detections with reliable optical counterparts. This is currently the largest radio-selected sample available out to z ~ 5 across an area of 2 square degrees with a sensitivity of rms ≈ 2.3 μJy beam-1. By fixing the faint and bright end shape of the radio luminosity function to the local values, we find a strong redshift trend that can be fitted with a pure luminosity evolution L1.4 GHz ∝ (1 + z)(3.16 ± 0.2)−(0.32 ± 0.07)z. We estimate star formation rates (SFRs) from our radio luminosities using an infrared (IR)-radio correlation that is redshift dependent. By integrating the parametric fits of the evolved luminosity function we calculate the cosmic SFR density (SFRD) history since z ~ 5. Our data suggest that the SFRD history peaks between 2 < z < 3 and that the ultraluminous infrared galaxies (100 M⊙ yr-1 < SFR < 1000 M⊙ yr-1) contribute up to ~25% to the total SFRD in the same redshift range. Hyperluminous infrared galaxies (SFR > 1000 M⊙ yr-1) contribute an additional ≲2% in the entire observed redshift range. We find evidence of a potential underestimation of SFRD based on ultraviolet (UV) rest-frame observations of Lyman break galaxies at high redshifts (z ≳ 4) on the order of 15–20%, owing to appreciable star formation in highly dust-obscured galaxies, which might remain undetected in such UV observations.
After G-protein-coupled receptor activation and signaling at the plasma membrane, the receptor complex is often rapidly internalized via endocytic vesicles for trafficking into various intracellular ...compartments and pathways. The formation of signaling endosomes is recognized as a mechanism that produces sustained intracellular signals that may be distinct from those generated at the cell surface for cellular responses including growth, differentiation, and survival. Pituitary adenylate cyclase activating polypeptide (PACAP; Adcyap1) is a potent neurotransmitter/neurotrophic peptide and mediates its diverse cellular functions in part through internalization of its cognate G-protein-coupled PAC1 receptor (PAC1R; Adcyap1r1). In the present study, we examined whether PAC1R endocytosis participates in the regulation of neuronal excitability. Although PACAP increased excitability in 90% of guinea pig cardiac neurons, pretreatment with Pitstop 2 or dynasore to inhibit clathrin and dynamin I/II, respectively, suppressed the PACAP effect. Subsequent addition of inhibitor after the PACAP-induced increase in excitability developed gradually attenuated excitability with no changes in action potential properties. Likewise, the PACAP-induced increase in excitability was markedly decreased at ambient temperature. Receptor trafficking studies with GFP-PAC1 cell lines demonstrated the efficacy of Pitstop 2, dynasore, and low temperatures at suppressing PAC1R endocytosis. In contrast, brefeldin A pretreatments to disrupt Golgi vesicle trafficking did not blunt the PACAP effect, and PACAP/PAC1R signaling still increased neuronal cAMP production even with endocytic blockade. Our results demonstrate that PACAP/PAC1R complex endocytosis is a key step for the PACAP modulation of cardiac neuron excitability.
We studied the individual and joint acute toxicity of S-metolachlor (SMOC) and deethylatrazine (DEA - a metabolite of atrazine) on different non-target freshwater crustaceans. We used animals from ...different ecological groups: two amphipods from surface running water (Gammarus pulex and Gammarus cf. orinos), an isopod from surface stagnant water (Asellus aquaticus) and an amphipod living in groundwater (Niphargus rhenorhodanensis). Organisms were exposed to different levels of SMOC and DEA, alone or in binary mixture. Temperature effect on SMOC toxicity was assessed by exposing G. pulex and N. rhenorhodanensis to SMOC at 11 °C and 15 °C. Studying mortality as the biological endpoint, N. rhenorhodanensis was more resistant than surface water species towards SMOC and DEA. Among surface water species, G. pulex was the most sensitive while Gammarus cf. orinos and A. aquaticus showed similar responses to both compounds. Temperature increase did not change SMOC toxicity but modify the shape and steepness of the dose-response curve. We used a Model Deviation Ratio (MDR) approach to evaluate the predictability of Concentration Addition (CA) and Independent Action (IA) models to mixture toxicity. Results indicated either an additive or an antagonistic or a synergistic interaction depending on the concentrations combination and the test species. Our finding conclusively show the suitability of CA and IA in predicting mixture toxicities but results should be interpreted with caution according to ecological group of exposed species in risk assessment procedures.
•S-metolachlor (SMOC) and deethylatrazine (DEA) toxicities on non-target crustaceans.•SMOC and DEA are more toxic to surface water species than groundwater one.•Temperature rise did not affect SMOC toxicity but increased its potency.•Joint action predictability by Concentration Addition - Independent Action models.•Significance of species ecological group in risk assessment procedures.
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