The A Silva granodiorite is a plutonic body intruded into the metasediments of the upper unit of the Órdenes Complex (Variscan belt, NW Spain). These metasediments represent the middle section of a ...magmatic arc located in northern Gondwana. The A Silva granodiorite has been classically considered a late Variscan granite. In this work, new field mapping, structural analysis, and SHRIMP U–Pb zircon dating indicate the granodiorite is significantly older. However, the data indicate a concordant age range between 540 and 460
Ma, and therefore CL images are not useful toward the interpretation of the geochronological results. This issue can be unravelled by using the hafnium and rare earth element composition of zircon in the assessment of the age. In this way, we determined that the age distribution was the result of lead loss, rather than a real age scatter or inheritance, and we could obtain a
206Pb/
238U crystallization age of 510.28 (+
1.57, −
1.44)
Ma using the TuffZirc algorithm.
This age together with the well-preserved field relationships of the host rock permit us to interpret the A Silva granodiorite as multiple sheets intruded into a sequence of metatexitic host rocks after crustal thickening and subsequent decompression that developed coeval with partial melting during the latest stages of a regional extensional event. Taken together with the underlying Monte Castelo gabbro (499
±
2
Ma), the whole plutonic complex reaches 8
km in thickness and forms an antiformal stack structure in a shear parallel (N–S) cross-section. This structure could be responsible for previously described, localized granulite facies metamorphism.
The presence of a late Cambrian magmatic event has been widely reported in other areas of northern Gondwana and it is related to the opening of the Rheic Ocean.
Sinonasal mucosal melanoma is an aggressive malignancy with a 5-year survival rate ranging from 20% to 39%. Despite the evolving surgical and radiotherapy techniques, and introduction of ...immune-checkpoint inhibitor therapy, overall survival rates remain poor.
A retrospective cohort study was conducted at the Hospital Clinic de Barcelona and the Hospital de la Santa Creu i Sant Pau between 1984 and 2020; primary outcome measures were 3 and 5-year melanoma-specific survival (MSS). Kaplan-Meier survival analysis and Cox proportional hazards model were performed to identify predictors of survival.
Fifty patients were included, the mean age was 70.4, MSS at 3 and 5 years was 51.2%, and 29.5%, respectively. The median follow-up was 39.6 months during which 46% presented locoregional recurrence and 36%, metastasis. The univariate and multivariate analyses found as survival predictors the N category, the treatment received, the surgical margins and the mitotic index.
We found an overall 5-year MSS of 29.5%. Those patients with intention-to-cure (stages III and IVa) treated by surgery that were N0 at diagnosis, with < 10 mitoses per HPF showed a 5-year MSS rate of 74.1%. More studies will be needed to adequately define the patients' profiles that will benefit from a better survival outcome.
Planck intermediate results Aghanim, N; Ashdown, M; Aumont, J ...
Astronomy and astrophysics (Berlin),
12/2016, Letnik:
596
Journal Article
Recenzirano
Odprti dostop
Using the Planck 2015 data release (PR2) temperature maps, we separate Galactic thermal dust emission from cosmic infrared background (CIB) anisotropies. For this purpose, we implement a specifically ...tailored component-separation method, the so-called generalized needlet internal linear combination (GNILC) method, which uses spatial information (the angular powerspectra) to disentangle the Galactic dust emission and CIB anisotropies. We produce significantly improved all-sky maps of Planck thermal dust emission, with reduced CIB contamination, at 353, 545, and 857 GHz. By reducing the CIB contamination of the thermal dust maps, we provide more accurate estimates of the local dust temperature and dust spectral index over the sky with reduced dispersion, especially at high Galactic latitudes above b= + or -20degrees. We find that the dust temperature is T= (19.4 + or - 1.3) K and the dust spectral index is beta= 1.6 + or - 0.1 averaged over the whole sky, while T= (19.4 + or - 1.5) K and beta= 1.6 + or - 0.2 on 21% of the sky at high latitudes. Moreover, subtracting the new CIB-removed thermal dust maps from the CMB-removed Planck maps gives access to the CIB anisotropies over 60% of the sky at Galactic latitudes b > 20degrees. Because they are a significant improvement over previous Planck products, the GNILC maps are recommended for thermal dust science. The new CIB maps can be regarded as indirect tracers of the dark matter and they are recommended for exploring cross-correlations with lensing and large-scale structure optical surveys. The reconstructed GNILC thermal dust and CIB maps are delivered as Planck products.
Treatment of postoperative enterocutaneous fistulae Barreiro Alvarez, F; Vicente Cantero, M; Zarazaga Monzon
Revista espanola de las enfermedades del aparato digestivo,
1978-Feb-01, Letnik:
52, Številka:
3
Journal Article
The implementation of post-fire stabilisation techniques in forests ecosystems located in the NW of Spain is required since high severity wildfires are common and the risk of erosion is high due to ...pronounced terrain relief in combination with abundant precipitation; however, there is limited quantitative information on the relative effectiveness of these techniques. The effectiveness of two stabilisation techniques, seeding and mulching, in reducing soil erosion was evaluated as well as their effects on soil quality. The study was performed on a hillslope area located in Laza (NW of Spain) affected by a high severity wildfire in September 2010. Four treatments were established: unburnt control soil, burnt control soil, burnt soil with rye seeding and burnt soil with straw mulch. For the different soil treatments, the sediments production as well as different physical, chemical and microbiological soil properties were measured over a four month period. The results showed that initially the wildfire induced important changes in most properties analyzed and that these effects persisted after 4months. The data also indicated that both stabilisation treatments had no effects on the soil properties analyzed but reduced significantly the sediments yield compared to that of the control burnt soil. The mean efficiency of seeding and mulching treatments in preventing soil erosion was 34–42% and 73–94%, respectively, showing that, in the short-term (4months), mulching was the most effective treatment for reducing post-fire erosion.
► Mulching and seeding treatments were applied immediately after the wildfire. ► The influence of these treatments on soil quality and soil erosion was evaluated. ► Fire induced drastic changes in soil physical, chemical and biological properties. ► The two stabilisation treatments had no short-term effects on soil quality. ► The mulching was the most effective treatment for reducing post-fire erosion.
In this work, we reported the synthesis and evaluation of the analgesic, antiinflammatory, and antiplatelet properties of new phenothiazine-attached acylhydrazone derivatives (6), designed exploring ...the molecular hybridization approach between antipsychotic chlorpromazine (4) and other heterocyclic derivatives (3) and (5) developed at LASSBio. Target compounds were synthesized in very good yields exploiting diphenylamine (7) as starting material, through regioselective functionalization of the C-1 position of 10H-phenothiazine ring. The evaluation of platelet antiaggregating profile lead us to identify a new potent prototype of antiplatelet derivative, that is (6a) (IC(50)=2.3 microM), which acts in arachidonic acid pathway probably by inhibition of platelet COX-1 enzyme. Additionally, the change of para-substituent group of acylhydrazone framework permitted us to identify hydrophilic carboxylate derivative (6g) and hydrophobic bromo derivative (6b) as two new leads of analgesics more active than dipyrone used as standard and with selective peripheral or central mechanism of action.
Background
Pyoderma gangrenosum is a serious cutaneous complication seen in approximately 1 % of patients with inflammatory bowel disease (IBD). Oral corticosteroids are the mainstay treatment, ...although the evidence supporting their use is weak.
Aims
The purpose of this study was to investigate the characteristics of pyoderma gangrenosum associated with Crohn’s disease or ulcerative colitis and which treatments are prescribed in Spanish clinical practice.
Methods
In this retrospective, observational study, the medical records from all patients with IBD and a diagnosis of pyoderma gangrenosum attended by the gastroenterology departments of 12 Spanish hospitals were reviewed. Data on patient demographics and characteristics, underlying IBD and treatment, and pyoderma gangrenosum characteristics, treatment, and outcome were collected and analyzed.
Results
The data from 67 patients were analyzed (41 61.2 % women, 41 61.2 % with Crohn’s disease, 25 37.3 % with ulcerative colitis, and 1 1.5 % with indeterminate disease). The underlying disease was in remission in approximately one-third of patients at the time of presentation of pyoderma gangrenosum. Healing was achieved in all patients (in 3 without any systemic therapy). Oral corticosteroids were taken by 51 patients (76.1 %), almost always as first-line treatment, although definitive healing was attained in 19 (28.4 %). Biologic agents such as infliximab and adalimumab were taken by 31 patients (46.3 %) at some point (first-line in 6 patients 9.0 %), with definitive healing in 29 patients (93.5 %).
Conclusions
Oral corticosteroid therapy remains the most common treatment for pyoderma gangrenosum associated with inflammatory bowel disease. Biologic therapies such as infliximab and adalimumab should also be considered.
Surgery of gastric cancer Barreiro Alvarez, F; Monlina Esteban, J; Vicente Cantero, M
Revista espanola de las enfermedades del aparato digestivo,
1977-Jun-01, Letnik:
50, Številka:
5
Journal Article
Gastric leiomyomas. Study of 5 personal cases Barreiro Alvarez, F; Aguinaga Manzanos, M V; Molina Esteban, J
Revista espanola de las enfermedades del aparato digestivo,
1977-May-01, Letnik:
50, Številka:
3
Journal Article
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