Cette étude a pour objectif d’explorer l’impact de l’image du corps et du vécu corporel de jeunes mères sur leur bonding, le lien émotionnel unissant un parent à son nourrisson dans les premiers ...temps après la naissance. Un échantillon de 565 femmes, âgées de 18 à 45 ans, ont répondu en ligne à un questionnaire portant sur leurs données sociodémographiques et obstétricales, un questionnaire sur l’image du corps et un questionnaire sur le bonding. Les résultats mettent en évidence l’impact négatif d’une satisfaction corporelle moindre, d’une perception du corps comme peu féminin et d’un état de tension corporelle sur le lien précoce de la mère à son nourrisson.
Abstract
We report VLA B-configuration observations of the H
i
21 cm line on the close disk galaxy pair NGC 5595 and NGC 5597. At the angular resolution of the observations, ∼7.″1 × 4.″2, while most ...of the H
i
21 cm in NGC 5595 and NGC 5597 has the same extent as the optical disk, we have detected for the first time extended structures (streamers) to the northeast (NE) and southwest (SW) of NGC 5595 with no counterparts in blue, red optical (continuum), 20 cm radio continuum, or H
α
spectral line emission. One structure is extended by ∼45″ to the NE with blueshifted velocities, and the other is extended by ∼20″ to the SW with redshifted velocities with respect to the systemic velocity. No H
i
21 cm emission is detected from the innermost central (nuclear) regions of either galaxy. Lower angular resolution H
i
21 cm imaging indicates the nonexistence of any intergalactic hydrogen atomic H
i
21 cm gas as tails or bridges between the two galaxies. Our new 20 cm radio continuum emission image of NGC 5597 shows a strong unresolved elongated structure in the central region, in the NE–SW direction, very similar to the spatial location of the innermost H
α
spectral line emission. There is no 20 cm continuum emission from its northern spiral arm. In NGC 5595, the 20 cm radio continuum image shows no continuum emission from the NE or SW extended structures with H
i
21 cm emission.
Abstract
We report Very Large Array B-configuration observations of the atomic hydrogen 21 cm line emission from the barred disk galaxy NGC 5597 at an angular resolution of ∼ 7.″1 × 4.″2. Using the ...resonance method, and assuming the ratio of the corotation radius to the semimajor axis of the stellar bar is unity (
≡
R
CR
/
a
bar
=
1
), we estimate the angular pattern speed of the stellar bar to be, Ω
bar
∼ 15.3 km s
−1
kpc
−1
. This constant value for Ω
bar
crosses Ω
gas
+
κ
(
R
)/4 at a distance ∼6.73 kpc, which would correspond to the spatial location of the north spiral structure near an outer
m
= 4 resonance. This value of Ω
bar
is similar to the values estimated for other bright nearby barred galaxies that exhibit circumnuclear rings (near inner Lindblad resonance) or outer rings (near outer Lindblad resonance).
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with steadily increasing incidence and poor prognosis. Despite recent success with immunotherapy, 50% of patients still ...succumb to their diseases. To date, there is no Food and Drug Administration-approved targeted therapy for advanced MCC. Aberrant activation of phosphatidylinositide-3-kinase (PI3K)/AKT/mTOR pathway is frequently detected in MCC, making it an attractive therapeutic target. We previously found PI3K pathway activation in human MCC cell lines and tumors and demonstrated complete clinical response in a Stage IV MCC patient treated with PI3K inhibitor idelalisib. Here, we found that both PI3K-α and -δ isoforms are abundantly expressed in our MCC cell lines and clinical samples; we therefore examined antitumor efficacy across a panel of five PI3K inhibitors with distinctive isoform-specificities, including idelalisib (PI3K-δ), copanlisib (PI3K-α/δ), duvelisib (PI3K-γ/δ), alpelisib (PI3K-α), and AZD8186 (PI3K-β/δ). Of these, copanlisib exerts the most potent antitumor effects, markedly inhibiting cell proliferation, survival, and tumor growth by suppressing PI3K/mTOR/Akt activities in mouse models generated from MCC cell xenografts and patient-derived tumor xenografts. These results provide compelling preclinical evidence for application of copanlisib in advanced MCC with aberrant PI3K activation for which immunotherapy is insufficient, or patients who are unsuitable for immunotherapy.
Over the last decades, microRNAs (miRNAs) have emerged as important molecules associated with the regulation of gene expression in humans and other organisms, expanding the strategies available to ...diagnose and handle several diseases. This paper presents a systematic review of literature of miRNAs related to cancer development and explores the main techniques used to quantify these molecules and their limitations as screening strategy. The bibliographic research was conducted using the online databases, PubMed, Google Scholar, Web of Science, and Science Direct searching the terms "microRNA detection", "miRNA detection", "miRNA and prostate cancer", "miRNA and cervical cancer", "miRNA and cervix cancer", "miRNA and breast cancer", and "miRNA and early cancer diagnosis". Along the systematic review over 26,000 published papers were reported, and 252 papers were returned after applying the inclusion and exclusion criteria, which were considered during this review. The aim of this study is to identify potential miRNAs related to cancer development that may be useful for early cancer diagnosis, notably in the breast, prostate, and cervical cancers. In addition, we suggest a preliminary top 20 miRNA panel according to their relevance during the respective cancer development. Considering the progressive number of new cancer cases every year worldwide, the development of new diagnostic tools is critical to refine the accuracy of screening tests, improving the life expectancy and allowing a better prognosis for the affected patients.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Our paper reviews recent progress in the study and understanding of observed trends in extreme rainfall events in the Metropolitan Area of São Paulo (MASP). These are discussed in relation to ...hydrometeorological hazards that trigger natural disasters, such as flash floods, landslides, and droughts, that affect the population and local economies. A review of the most updated literature on rainfall and extremes in the MASP shows a significant increase in the total volume of rainy‐season rainfall during the last seven decades. While there were practically no days with heavy rain (more than 50 mm) in the 1950s, these days have been occurring two to five times a year in the last 10 years. This, together with the inappropriate occupation of risky areas, such as slopes and banks of watercourses, leads to inundation, flooding, and landslides. Changes in extremes can be partly due to natural climate variability but can also be related to global warming and/or urbanization. There is ample evidence of an increasing risk of rainfall‐related hazards in the MASP. This is particularly so for landslides in vulnerable areas. Exposure will continue to lead to risk increases. This calls for significant improvement in climate and disaster risk reduction and management efforts in the MASP region.
Our review discusses the nexus between extremes of rainfall and climate‐related natural disasters in the Metropolitan Area of São Paulo (MASP). Our objectives are to (1) provide the most updated review of observed precipitation extreme trends in the MASP region, (2) review current knowledge on possible impacts of trends toward increases in extremes of rainfall on the frequency of natural disasters, (3) inform about future changes in the number and severity of weather and climate‐related disasters in the next decades, and (4) discuss how vulnerability to climate‐related disasters has evolved over time and how this information is needed for impact studies and to define policies cities can adapt to cope with climate variability and change.
Degradation kinetics of epoxidized soybean oil Barreto, J. V. M.; Albuquerque, A. K. C.; Ries, Andreas ...
Journal of applied polymer science,
September 5, 2023, Letnik:
140, Številka:
33
Journal Article
Recenzirano
This work deals with the degradation kinetics of epoxidized soybean oil, whereas the weight loss of epoxidized soybean oil (ESO) cured with methyl tetrahydrophthalic anhydride (MTHPA) as hardener and ...2,4,6‐tris (dimethylaminomethyl) phenol (DEH 35) as catalyst displayed two main regions in the thermogravimetry (TG) plots. Nevertheless, deconvolution of the weight loss plots presented three or more events depending on the composition and experimental parameters. Increase the MTHPA addition led to a decrease in the activation energy (AE) for curing which conducted to an increased AE during the degradation. Friedman's isoconversional model exhibits proper R2 for the curing kinetics, but lower R2 values for lower anhydride contents during the degradation kinetics analyses. Kissinger‐Akahira‐Sunose (KAS) and Ozawa‐Flynn‐Wall (OFW) models displayed the best R2 during the kinetics evaluation, whereas the degradation mechanisms fitted reasonably with Avrami‐Erofeev (An) and nth‐order autocatalytic (Cn) during the first and second weight loss regions. Microstructural analyzes and in‐depth investigations into the thermal degradation mechanism of ESO suggest two possible pathways, that is, production of carbonic groups through heterolytic scission, and formation of electrically stable groups with saturated carbon bonds.
Reaction mechanism for epoxy‐anhydride polymerization initiated by DEH35, including the termination step.
•-Some community-onset pneumonias are caused by drug resistant pathogens.•-There is no consensual rule to identify patients who need wider spectrum antibiotics.•-In a prospective cohort study, we aim ...to identify risk factors for resistant agents.•-Previous antibiotic use and being bed-ridden were independent risk factors.•-Our multivariable model has a discriminative power of 0.832, 95%CI 0.756–0.908.
: There is no consensual definition of risk factors for drug resistant pathogens (DRP) in community-onset pneumonia (COP). Healthcare-associated pneumonia criteria have been abandoned because they were found to have weak discriminative power. Our aim was to identify risk factors for DRP in COP.
: Prospective cohort study, conducted over a two years’ period, in a community-based hospital, including all adult patients with COP criteria. Univariate and multivariate logistic regression modeling were performed to understand the association of risk factors (demographic, clinical and epidemiological) with COP by a DRP (PES: Pseudomonas aeruginosa, extended-spectrum ß-lactamase producing Enterobacteriaceae, Methicillin-resistant Staphylococcus aureus; and other non-fermenting gram-negative bacteria, namely Acinetobacter baumannii).
: A total of 660 cases of COP were included, with a mean (±SD) age of 74±15 years and 58.9% of males. Microbiological documentation was possible in 32.6% of the cases. There were 197 cases selected for further analysis, of which 37 were cases of PES. The multivariate logistic regression model retained antibiotic use in the previous 90 days (adjusted OR=4.411, 95%CI 1.745-11.148) and being bed-ridden (adjusted OR=5.492, 95%CI 2.121-14.222), adjusted for Charlson's Index, CURB 65 and provenience from a long-term care facility. The area under the ROC curve for this model was 0.832, 95%CI 0.756-0.908, higher than the application of the HCAP criteria (AUROC = 0.676, 95%CI 0.582-0.770).
: In this study, antibiotic use in the previous 90 days and being bed-ridden were independently associated with COP caused by DRP, after adjustment for Charlson's Index, CURB 65 and provenience from a long-term care facility.
This paper presents a new algorithm for the extrinsic calibration of a perspective camera and an invisible 2D laser-rangefinder (LRF). The calibration is achieved by freely moving a checkerboard ...pattern in order to obtain plane poses in camera coordinates and depth readings in the LRF reference frame. The problem of estimating the rigid displacement between the two sensors is formulated as one of registering a set of planes and lines in the 3D space. It is proven for the first time that the alignment of three plane-line correspondences has at most eight solutions that can be determined by solving a standard p3p problem and a linear system of equations. This leads to a minimal closed-form solution for the extrinsic calibration that can be used as hypothesis generator in a RANSAC paradigm. Our calibration approach is validated through simulation and real experiments that show the superiority with respect to the current state-of-the-art method requiring a minimum of five input planes.
The role of adjuvant transarterial chemoembolization (TACE) for patients with resectable hepatocellular carcinoma (HCC) undergoing hepatectomy is currently unclear. We performed a systematic review ...of the literature using the MEDLINE, Embase, and Cochrane Library databases. Random-effects meta-analysis was carried out to compare the overall survival (OS) and recurrence-free survival (RFS) of patients with resectable HCC undergoing hepatectomy followed by adjuvant TACE vs. hepatectomy alone in randomized controlled trials (RCTs). The risk of bias was assessed using the Risk of Bias 2.0 tool. Meta-regression analyses were performed to explore the effect of hepatitis B viral status, microvascular invasion, type of resection (anatomic vs. parenchymal-sparing), and tumor size on the outcomes. Ten eligible RCTs, reporting on 1216 patients in total, were identified. The combination of hepatectomy and adjuvant TACE was associated with superior OS (hazard ratio (HR): 0.66, 95% confidence interval (CI): 0.52 to 0.85; p < 0.001) and RFS (HR: 0.70, 95% CI: 0.56 to 0.88; p < 0.001) compared to hepatectomy alone. There were significant concerns regarding the risk of bias in most of the included studies. Overall, adjuvant TACE may be associated with an oncologic benefit in select HCC patients. However, the applicability of these findings may be limited to Eastern Asian populations, due to the geographically restricted sample. High-quality multinational RCTs, as well as predictive tools to optimize patient selection, are necessary before adjuvant TACE can be routinely implemented into standard practice. PROSPERO Registration ID: CRD42021245758.
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