Abstract
We present a new and independent determination of the local value of the Hubble constant based on a calibration of the tip of the red giant branch (TRGB) applied to Type Ia supernovae ...(SNe Ia). We find a value of
H
0
= 69.8 ± 0.8 (±1.1% stat) ± 1.7 (±2.4% sys) km s
−1
Mpc
−1
. The TRGB method is both precise and accurate and is parallel to but independent of the Cepheid distance scale. Our value sits midway in the range defined by the current Hubble tension. It agrees at the 1.2
σ
level with that of the Planck Collaboration et al. estimate and at the 1.7
σ
level with the
Hubble Space Telescope
(
HST
)
SHoES
measurement of
H
0
based on the Cepheid distance scale. The TRGB distances have been measured using deep
HST
Advanced Camera for Surveys imaging of galaxy halos. The zero-point of the TRGB calibration is set with a distance modulus to the Large Magellanic Cloud of 18.477 ± 0.004 (stat) ± 0.020 (sys) mag, based on measurement of 20 late-type detached eclipsing binary stars, combined with an
HST
parallax calibration of a 3.6
μ
m Cepheid Leavitt law based on
Spitzer
observations. We anchor the TRGB distances to galaxies that extend our measurement into the Hubble flow using the recently completed Carnegie Supernova Project I ( CSP-I ) sample containing about 100 well-observed SNe Ia . There are several advantages of halo TRGB distance measurements relative to Cepheid variables; these include low halo reddening, minimal effects of crowding or blending of the photometry, only a shallow (calibrated) sensitivity to metallicity in the
I
band, and no need for multiple epochs of observations or concerns of different slopes with period. In addition, the host masses of our TRGB host-galaxy sample are higher, on average, than those of the Cepheid sample, better matching the range of host-galaxy masses in the CSP-I distant sample and reducing potential systematic effects in the SNe Ia measurements.
Mitochondrial membrane biogenesis and lipid metabolism require phospholipid transfer from the endoplasmic reticulum (ER) to mitochondria. Transfer is thought to occur at regions of close contact of ...these organelles and to be nonvesicular, but the mechanism is not known. Here we used a novel genetic screen in S. cerevisiae to identify mutants with defects in lipid exchange between the ER and mitochondria. We show that a strain missing multiple components of the conserved ER membrane protein complex (EMC) has decreased phosphatidylserine (PS) transfer from the ER to mitochondria. Mitochondria from this strain have significantly reduced levels of PS and its derivative phosphatidylethanolamine (PE). Cells lacking EMC proteins and the ER-mitochondria tethering complex called ERMES (the ER-mitochondria encounter structure) are inviable, suggesting that the EMC also functions as a tether. These defects are corrected by expression of an engineered ER-mitochondrial tethering protein that artificially tethers the ER to mitochondria. EMC mutants have a significant reduction in the amount of ER tethered to mitochondria even though ERMES remained intact in these mutants, suggesting that the EMC performs an additional tethering function to ERMES. We find that all Emc proteins interact with the mitochondrial translocase of the outer membrane (TOM) complex protein Tom5 and this interaction is important for PS transfer and cell growth, suggesting that the EMC forms a tether by associating with the TOM complex. Together, our findings support that the EMC tethers ER to mitochondria, which is required for phospholipid synthesis and cell growth.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We present an analysis of the final data release of the Carnegie Supernova Project I, focusing on the absolute calibration of the luminosity-decline rate relation for Type Ia supernovae (SNe Ia) ...using new intrinsic color relations with respect to the color-stretch parameter, sBV, enabling improved dust extinction corrections. We investigate to what degree the so-called fast-declining SNe Ia can be used to determine accurate extragalactic distances. We estimate the intrinsic scatter in the luminosity-decline rate relation and find it ranges from 0.13 mag to 0.18 mag with no obvious dependence on wavelength. Using the Cepheid variable star data from the SH0ES project, the SN Ia distance scale is calibrated and the Hubble constant is estimated using our optical and near-infrared sample, and these results are compared to those determined exclusively from a near-infrared subsample. The systematic effect of the supernova's host galaxy mass is investigated as a function of wavelength and is found to decrease toward redder wavelengths, suggesting this effect may be due to dust properties of the host. Using estimates of the dust extinction derived from optical and near-infrared wavelengths and applying these to the H band, we derive a Hubble constant , whereas using a simple B − V color correction applied to the B band yields . Photometry of two calibrating SNe Ia from the CSP-II sample, SN 2012ht and SN 2015F, is presented and used to improve the calibration of the SN Ia distance ladder.
Scholarship on distributive politics focuses almost exclusively on the internal operations of Congress, paying particular attention to committees and majority parties. This article highlights the ...president, who has extensive opportunities, both ex ante and ex post, to influence the distribution of federal outlays. We analyze two databases that track the geographic spending of nearly every domestic program over a 24-year period—the largest and most comprehensive panels of federal spending patterns ever assembled. Using district and county fixed-effects estimation strategies, we find no evidence of committee influence and mixed evidence that majority party members receive larger shares of federal outlays. We find that districts and counties receive systematically more federal outlays when legislators in the president's party represent them.
Earnings nonresponse in household surveys is widespread, yet there is limited knowledge of how nonresponse biases earnings measures. We examine the consequences of nonresponse on earnings gaps and ...inequality using Current Population Survey individual records linked to administrative earnings data. The common assumption that earnings are missing at random is rejected. Nonresponse across the earnings distribution is U-shaped, highest in the left and right tails. Inequality measures differ between household and administrative data due in part to nonresponse. Nonresponse biases earnings differentials by race, gender, and education, particularly in the tails. Flexible copula-based models can account for nonrandom nonresponse.
The aim of this study was to examine the effect of skeletal muscle stretching on peripheral, central, and autonomic cardiovascular responses in humans. Twelve healthy males completed a controlled ...passive stretch of the plantar flexors for 4 min at three different intensities. Doppler ultrasound velocimetry and imaging techniques assessed mean leg blood flow (MLBF), antegrade blood flow, and retrograde blood flow of the popliteal artery. Near-infrared spectroscopy assessed the concentration of deoxygenated hemoglobin + myoglobin (HHb) and the sum of its deoxygenated and oxygenated forms i.e., blood volume (Hbtot). Heart rate (HR) and mean arterial pressure were measured simultaneously to peripheral hemodynamic responses. During stretch there was an increase (P < 0.05) in antegrade and retrograde blood flow along with HHb and Hbtot relative to baseline, whereas MLBF was not altered. HR increased (P < 0.01) in a stretch intensity- and time-dependent manner, suggesting a threshold tension must be met that results in a mechanoreflex-mediated increase in HR. After stretch there was an increase (P < 0.05) in Hbtot and MLBF in each condition, suggesting that stretch creates a poststretch hyperemic response. Furthermore, retrograde blood flow was decreased (P < 0.05) after stretch in each stretch condition. Mean arterial pressure was decreased (P < 0.05) after moderate-intensity stretching. Collectively, our data provide novel mechanistic evidence on cardiovascular responses to skeletal muscle stretching in humans. Moreover, the reductions in MAP and retrograde blood flow suggest that stretch transiently reduces myogenic vascular tone in a poststretch resting period.
We present an updated analysis of the intrinsic colors of Type Ia supernova (SNe Ia) using the latest data release of the Carnegie Supernova Project. We introduce a new light-curve parameter very ...similar to stretch that is better suited for fast-declining events, and find that these peculiar types can be seen as extensions to the population of "normal" SNe Ia. With a larger number of objects, an updated fit to the Lira relation is presented along with evidence for a dependence on the late-time slope of the B - V light-curves with stretch and color. Using the full wavelength range from u to H band, we place constraints on the reddening law for the sample as a whole and also for individual events/hosts based solely on the observed colors. The photometric data continue to favor low values of R sub(V), though with large variations from event to event, indicating an intrinsic distribution. We confirm the findings of other groups that there appears to be a correlation between the derived reddening law, R sub(V), and the color excess, E(B - V), such that larger E(B - V) tends to favor lower R sub(V). The intrinsic u-band colors show a relatively large scatter that cannot be explained by variations in R sub(V) or by the Goobar power-law for circumstellar dust, but rather is correlated with spectroscopic features of the supernova and is therefore likely due to metallicity effects.
Abstract Objective Recent work on arousal vs. activation in adults showed that skin conductance levels (SCLs) increased, and global alpha levels decreased, from eyes-closed to eyes-open resting ...baseline conditions. This study explored whether similar effects occur in children. Methods EEG activity was recorded from 30 children aged 8–12 years during counterbalanced eyes-closed and eyes-open resting conditions; SCL was measured as an index of arousal. Results SCLs were negatively correlated with mean alpha levels in the eyes-closed condition, and increased significantly from eyes-closed to eyes-open. Reductions were found in across-scalp mean absolute delta, theta, alpha, and beta from eyes-closed to eyes-open. Topographic changes were evident in all bands except alpha. Conclusions Results confirm the use of mean alpha level as a measure of resting-state arousal under eyes-closed and eyes-open conditions. Focal changes in the other bands suggest that these reflect differences in activation, rather than the simple increase in arousal shown in alpha. Significance This child study confirms the generality of eyes-closed vs. eyes-open non-alpha EEG measures differing in mean power levels and topography, the latter indicating brain activity related to visual processing. Such differences should be considered when evaluating EEG research, and in choosing baseline conditions for different paradigms.
Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found ...that binding of proteins to the ubiquitous signaling lipid phosphatidic acid (PA) depended on intracellular pH and the protonation state of its phosphate headgroup. In yeast, a rapid decrease in intracellular pH in response to glucose starvation regulated binding of PA to a transcription factor, Opi1, that coordinately repressed phospholipid metabolic genes. This enabled coupling of membrane biogenesis to nutrient availability.
The Carnegie Supernova Project (CSP) is a five-year survey being carried out at the Las Campanas Observatory to obtain high-quality light curves of ~100 low-redshift Type Ia supernovae (SNe Ia) in a ...well-defined photometric system. Here we present the first release of photometric data that contains the optical light curves of 35 SNe Ia, and near-infrared light curves for a subset of 25 events. The data comprise 5559 optical (ugriBV) and 1043 near-infrared (Y JHKs ) data points in the natural system of the Swope telescope. Twenty-eight SNe have pre-maximum data, and for 15 of these, the observations begin at least 5 days before B maximum. This is one of the most accurate data sets of low-redshift SNe Ia published to date. When completed, the CSP data set will constitute a fundamental reference for precise determinations of cosmological parameters, and serve as a rich resource for comparison with models of SNe Ia.
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