Provider: - Institution: Internet Culturale / Biblioteca Nazionale - Cosenza - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the ...Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: Internet Culturale / Biblioteca Nazionale - Cosenza - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the ...Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: Internet Culturale / Biblioteca Nazionale - Cosenza - Data provided by Europeana Collections- A p. 3-4: Argomento ; Alle pp. 5-6: Personaggi, scenografi, orchestrali e altre ...responsabilità ; 1. rappr.: 23.01.1845- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: Internet Culturale / Biblioteca Nazionale - Cosenza - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the ...Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
: From March to May 2020, lockdown measures were adopted in Italy to contain the epidemic of the novel Coronavirus. People were forced to restrict their movement and social contacts, therefore having ...a higher risk of inactivity. This study, carried out among Italian undergraduates, explored their sedentary and physical activities (PA) during the lockdown with respect to their previous habits.
: An electronic questionnaire was administered once to students attending three Italian universities after the end of lockdown.
: A total of 1430 students (mean age 22.9 ± 3.5 years, 65.5% females) completed the questionnaire. All the sedentary behaviors increased significantly, and all the physical activities decreased significantly during the lockdown. Time spent using electronic devices showed the highest increase (+52.4 min/day), and walking the greatest decrease (-365.5 min/week). Being younger than 22 years old, female, and previously active, attending the universities of Naples and Rome and having at least one graduate parent were associated with the achievement of recommended levels of PA even during the lockdown.
: This study highlights the reduction of PA among Italian undergraduates in the course of home-confinement due to the CoViD-19 pandemic. The practice of adequate PA during the lockdown was mainly associated with the previous adoption of an active lifestyle. Promoting active lifestyles during the non-pandemic period may have had positive effects also in case of lockdown.
Background A supplemented very-low-protein diet (sVLPD) seems to be safe when postponing dialysis therapy. Study Design Prospective multicenter randomized controlled study designed to assess the ...noninferiority of diet versus dialysis in 1-year mortality assessed by using intention-to-treat and per-protocol analysis. Setting & Participants Italian uremic patients without diabetes older than 70 years with glomerular filtration rate of 5 to 7 mL/min (0.08 to 0.12 mL/s). Intervention Randomization to an sVLPD (diet group) or dialysis. The sVLPD is a vegan diet (35 kcal; proteins, 0.3 g/kg body weight daily) supplemented with keto-analogues, amino acids, and vitamins. Patients following an sVLPD started dialysis therapy in the case of malnutrition, intractable fluid overload, hyperkalemia, or appearance of uremic symptoms. Outcomes & Measurements Mortality, hospitalization, and metabolic markers. Results 56 patients were randomly assigned to each group, median follow-up was 26.5 months (interquartile range, 40), and patients in the diet group spent a median of 10.7 months (interquartile range, 11) following an sVLPD. Forty patients in the diet group started dialysis treatment because of either fluid overload or hyperkalemia. There were 31 deaths (55%) in the dialysis group and 28 deaths (50%) in the diet group. One-year observed survival rates at intention to treat were 83.7% (95% confidence interval CI, 74.5 to 94.0) in the dialysis group versus 87.3% (95% CI, 78.9 to 96.5) in the diet group (log-rank test for noninferiority, P < 0.001; for superiority, P = 0.6): the difference in survival was −3.6% (95% CI, −17 to +10; P = 0.002). The hazard ratio for hospitalization was 1.50 for the dialysis group (95% CI, 1.11 to 2.01; P < 0.01). Limitations The unblinded nature of the study, exclusion of patients with diabetes, and incomplete enrollment. Conclusion An sVLPD was effective and safe when postponing dialysis treatment in elderly patients without diabetes.
IMPORTANCE: Previous retrospective studies have shown that sarcopenia substantially alters the postoperative and oncological outcomes after liver resection for malignant tumors. However, the evidence ...is limited to small retrospective studies with heterogeneous results and the lack of standardized measurements of sarcopenia. OBJECTIVE: To investigate the role of sarcopenia as a risk factor associated with 90-day morbidity after liver resection for malignant tumors. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included 234 consecutive patients undergoing liver resection for malignant tumors at San Camillo Forlanini Hospital, Rome, Italy, between June 1, 2018, and December 15, 2019. Muscle mass and strength were assessed using the skeletal muscle index (SMI) on preoperative computed tomographic scans and the handgrip strength test, respectively. Patients were then divided into the following 4 groups: group A (normal muscle mass and strength), group B (reduced muscle strength), group C (reduced muscle mass), and group D (reduced muscle mass and strength). MAIN OUTCOMES AND MEASURES: The primary outcome of the study was 90-day morbidity. The following secondary outcomes were investigated: 90-day mortality, hospital stay, and readmission rate. RESULTS: Sixty-four major and 170 minor hepatectomies were performed in 234 patients (median age, 66.50 interquartile range, 58.00-74.25 years; 158 men 67.5%). The median SMI of the entire population was 46.22 (interquartile range, 38.60-58.20) cm/m2. The median handgrip strength was 30.80 (interquartile range, 22.30-36.90) kg. Patients in group D had a statistically significantly higher rate of 90-day morbidity than patients in the other groups (51.5% 35 of 68 vs 38.7% 29 of 75 in group C, 23.1% 3 of 13 in group B, and 6.4% 5 of 78 in group A; P < .001). Compared with patients in the other groups, those in group D had a longer hospital stay (10 days vs 8 days in group C, 9 days in group B, and 6 days in group A; P < .001), and more patients in this group were readmitted to the hospital (8.8% 6 of 68 vs 5.3% 4 of 75 in group C, 7.7% 1 of 13 in group B, and 0% 0 of 78 in group A; P = .02). Sarcopenia, portal hypertension, liver cirrhosis, and biliary reconstruction were independent risk factors associated with 90-day morbidity. CONCLUSIONS AND RELEVANCE: Sarcopenia appears to be associated with adverse outcomes after liver resection for malignant tumors. Both muscle mass measurements on computed tomographic scans and muscle strength assessments with the handgrip strength test should be performed at the first clinical encounter to better classify patients and to minimize the risk of morbidity.
Background and Purpose
Palmitoylethanolamide (PEA) acts via several targets, including cannabinoid CB1 and CB2 receptors, transient receptor potential vanilloid type‐1 (TRPV1) ion channels, ...peroxisome proliferator‐activated receptor alpha (PPAR α) and orphan G protein‐coupled receptor 55 (GRR55), all involved in the control of intestinal inflammation. Here, we investigated the effect of PEA in a murine model of colitis.
Experimental Approach
Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid (DNBS). Inflammation was assessed by evaluating inflammatory markers/parameters and by histology; intestinal permeability by a fluorescent method; colonic cell proliferation by immunohistochemistry; PEA and endocannabinoid levels by liquid chromatography mass spectrometry; receptor and enzyme mRNA expression by quantitative RT‐PCR.
Key Results
DNBS administration caused inflammatory damage, increased colonic levels of PEA and endocannabinoids, down‐regulation of mRNA for TRPV1 and GPR55 but no changes in mRNA for CB1, CB2 and PPARα. Exogenous PEA (i.p. and/or p.o., 1 mg·kg−1) attenuated inflammation and intestinal permeability, stimulated colonic cell proliferation, and increased colonic TRPV1 and CB1 receptor expression. The anti‐inflammatory effect of PEA was attenuated or abolished by CB2 receptor, GPR55 or PPARα antagonists and further increased by the TRPV1 antagonist capsazepine.
Conclusions and Implications
PEA improves murine experimental colitis, the effect being mediated by CB2 receptors, GPR55 and PPARα, and modulated by TRPV1 channels.
In the last decades, the applications of structural monitoring are moving toward the field of civil engineering and infrastructures. Nevertheless, if the structures have damages, it does not mean ...that they have a complete loss of functionality, but rather that the system is no longer in an optimal condition so that, if the damage increases, the structure can collapse. Structural Health Monitoring (SHM), a process for the identification of damage, periodically collects data from suitable sensors that allow to characterize the damage and establishes the health status of the structure. Therefore, this monitoring will provide information on the structure condition, mostly about its integrity, in a short time, and, for infrastructures and civil structures, it is necessary to assess performance and health status. The aim of this work is to design an Internet of Things (IoT) system for Structural Health Monitoring to find possible damages and to see how the structure behaves over time. For this purpose, a customized datalogger and nodes have been designed. The datalogger is able to acquire the data coming from the nodes through RS485 communication and synchronize acquisitions. Furthermore, it has an internal memory to allow for the post-processing of the collected data. The nodes are composed of a digital triaxial accelerometer, a general-purpose microcontroller, and an external memory for storage measures. The microcontroller communicates with an accelerometer, acquires values, and then saves them in the memory. The system has been characterized and the damage indicator has been evaluated on a testing structure. Experimental results show that the estimated damage indicator increases when the structure is perturbed. In the present work, the damage indicator increased by a maximum value of 24.65 when the structure is perturbed by a 2.5 mm engraving.
The reliable monitoring of sea state parameters is a key factor for weather forecasting, as well as for ensuring the safety and navigation of ships. In the current analysis, two spectrum estimation ...techniques, based on the Welch and Thomson methods, were applied to a set of random wave signals generated from a theoretical wave spectrum obtained by combining wind sea and swell components with the same prevailing direction but different combinations of significant wave heights, peak periods, and peak enhancement factors. A wide benchmark study was performed to systematically apply and compare the two spectrum estimation methods. In this respect, different combinations of wind sea spectra, corresponding to four grades of the Douglas Scale, were combined with three swell spectra corresponding to different swell categories. The main aim of the benchmark study was to systematically investigate the effectiveness of the Welch and Thomson methods in terms of spectrum restitution and the assessment of sea state parameters. The spectrum estimation methods were applied to random wave signals with different durations, namely 600 s (short) and 3600 s (long), to investigate how the record length affected the assembled sea state parameters, which, in turn, were assessed by the nonlinear least square method. Finally, based on the main outcomes of the benchmark study, some suggestions are provided to select the most suitable spectrum reconstruction method and increase the effectiveness of the assembled sea state parameters.
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