After initial surgery, 240 pre-, peri- or postmenopausal patients with early node-negative breast carcinoma were randomized to receive either no hormone therapy or adjuvant therapy with ...medroxyprogesterone acetate at high dosage (HD-MPA; 500 mg IM per day times 28 or 500 mg intramuscularly (i.m.) 5 days a week for 5 weeks then 500 mg i.m. twice weekly for the 5 following months. After a median follow-up time of 3 years, relapse-free survival and overall survival appeared significantly improved in the HD-MPA arm. Side effects were tolerable.
A patient with diffuse hepatic arteriovenous microfistulae suffered from secondary high-output right ventricular failure, pulmonary hypertension, and ascites, all of which could be managed by ...selective embolization of the hepatic artery. The vascular lesion of the liver seems to be essential, although hemorrhagic hereditary telangiectasia , perhaps aggravated by administration of oral contraceptives, may be considered contributory factors in this case.
The aim of this study is to search for small underground side basins in order to propose them to agricultural businessmen. Those basins should be apt to a successful experiment of cultural techniques ...to reduce nitrogen leakages toward aquifers. They should allow to identify and try to quantify the reasons of nitrogen enrichment of the underground waters by a critical examination of the past of some reappearances and the use of their recharge basin. This work consisted, after drawing up evolution graphs of nitrate rates, in selecting springs at first according to their interannual variations amplitude with increasing nitrogen rates, secondly according to their moderate flow-having unimportant side basins and thin storage aquifer and therefore reacting rapidly to the surface attraction. Finally, the springs were selected according to their specified pollution so that the collected water should be a representative sample of the aquifer. Eleven spots were thus selected. We hope they will allow to draw an experiment over the 3 or 5 next years.
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