This research work was conducted to learn and understand the theological behaviors of churches that were plateauing or declining but turned around into a healthy and growing ministry. Since worship ...attendance is growing in only about a third of U.S. churches, the issue of church vitality is a critical one for the vast majority of churches struggling with church growth. This research work used a multiple-case design with a mixed-tool methodology to collect reliable data for a concrete and valid analysis of a turnaround process. The data analysis helped discern common patterns and contributing factors of the studied turnaround churches. Seven major findings were presented as three common patterns and four contributing factors. These major findings showed that people in these congregations were moved to responsible discipleship, committed worship, and generous giving. The highest ranked of the major findings was a central theological belief in Jesus as Lord that informed and defined all other theological behaviors and priorities of the congregations.
Peru had the second-highest number of COVID-19 cases in Latin America. After the first wave, Peru registered more than 900,000 cases of COVID-19 and more than 36,000 confirmed deaths from the ...disease. Tumbes, a border area with poor sanitation and not enough water, had the fifth highest death rate. The cross-sectional analytic study aimed: a) to assess seroprevalence of COVID-19 after the first wave; b) to assess sociodemographic determinants and symptoms associated with a positive COVID-19 antibody lateral flow test.
We performed this study between November 11th and November 30th, 2020, in an informal settlement in Tumbes. Individuals older than two years were invited to participate in a systematic random sample from one in every four households. Finger-prick blood samples were collected, and a census and symptom survey were applied. Within the chosen house, one adult over 18 years of age was chosen for a PCR-RT molecular test. Overall seroprevalence was 25.59%, adjusted seroprevalence was 24.82% (95%CI 22.49-27.25). Women had higher adjusted seroprevalence (28.03% vs 21.11%; 95% CI 24.83-31.41, p = 0.002). Symptoms as fever (PR 1.89: 95% CI 1.44-2.48, p<0.001), general discomfort (PR 1.67; 95% CI 1.23-2.26, p = 0.001), cough (PR 2.0; 95% CI 1.60-2.50, p<0.001), nasal congestion (PR 1.46; 95% CI 1.03-2.09, p = 0.036), respiratory distress (PR 1.64; 95% CI 1.04-2.56, p = 0.031), headache (PR 1.54; 95% CI 1.09-2.17, p = 0.014), anosmia (PR 1.78; 95% CI 1.01-3.14, p = 0.046) and ageusia (PR 2.31; 95% CI 1.48-3.61, p<0.001) were associated with a positive covid-19 antibody lateral flow test.
The COVID-19 transmission and distribution were highlighted by this cross-sectional study. The data will help the Ministry of Health improve its monitoring, surveillance, and monitoring of respiratory community sequelae in the future.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
BACKGROUND: Partner violence is a public health problem. In Peru, women with spouses are vulnerable to suffering it. The Woman Abuse Screening Tool (WAST) is a widely recommended instrument for the ...early identification of these cases. Therefore, our objective was to adapt and analyse the psychometric properties of the WAST scale in adult Peruvian women.
METHODOLOGY: This was an instrumental study, with a sample of 628 women who were in a marital condition of cohabitation or married at the time of the study. The mean age was 35 years (M = 35.58; SD = 10.92) and on average they were living with their partner for 9 years (M = 9.93; SD = 8.41). This sample was selected by non-probabilistic snowball sampling. The Woman Abuse Screening Tool (WAST), Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire (PHQ-9) were used. The validity of the internal structure was verified with confirmatory factor analysis (CFA), convergent validity by correlation coefficients between the WAST, GAD-7 and PHQ-9, while reliability was verified using Cronbach's alpha and McDonald's Omega coefficient.
RESULTS: Factorial analysis indicated that the one-dimensional model showed adequate goodness-of-fit indices (CFI = 0.998; TLI=0.991; RMSEA=0.103; SRMR=0.075), and reliability coefficients (α = 0.899 and ω = 0.916) were optimal. Additionally, the WAST showed strong external validity based on the relationship with the PHQ-9 and GAD-7 scores (Rho > 0.50).
CONCLUSIONS: The Woman Abuse Screening Tool (WAST) scale demonstrated solid evidence of internal and external validity and optimal reliability in adult Peruvian women. Its use will benefit the early identification of victims of intimate partner violence in primary health care and further research.
OBJETIVO: Adaptar y validar el Instrumento de Detección de Maltrato a la Mujer en estudiantes universitarias peruanas. METODOLOGÍA: Estudio instrumental desarrollado en 417 estudiantes universitarias ...seleccionadas por muestreo no probabilístico. El instrumento adaptado y validado fue el Woman Abuse Screening Tool (WAST). Se realizaron análisis descriptivos, de validez de contenido mediante la V de Aiken, de validez de constructo mediante el análisis factorial confirmatorio (AFC) y de fiabilidad mediante el alfa de Cronbach y el coeficiente Omega de McDonald. Para estos análisis se utilizó el programa estadístico del estudio R. RESULTADOS: Se encontraron valores adecuados en la validez de contenido mediante la V de Aiken (V= 0,89 - 1,00); asimismo, en cuanto al análisis factorial (CFA) el modelo unifactorial mostró mejores valores en los índices de ajuste como X2=48,037; GFI=0,997; CFI=0,994; TLI=0,992; SRMR=0,049; RMSEA=0,058 y en cuanto a la fiabilidad reportó un a=0,86 y w=0,90 dichos valores muestran que el instrumento es fiable. CONCLUSIONES: El instrumento de tamizaje de maltrato a la mujer versión peruana en español demostró valores psicométricos adecuados de validez y confiabilidad en mujeres universitarias, por lo que se recomienda su uso en el tamizaje de violencia de pareja.
Analiza las causas que a lo largo del proceso de producción dentro de una planta farmacéutica puedan generar mermas durante el proceso de acondicionado y su impacto económico. Propone mejoras en la ...producción y los procesos de acondicionado. Analiza y mide el impacto en los costos. Se propone reducir la cantidad de mermas a través de planes de acción y generar una política de prevención de las mismas.
Trabajo de suficiencia profesional
Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and cerebellar/neural tube ...malformation. Whether defects in kidney, retinal, or neural disease primarily involve ciliary, Hedgehog, or cell polarity pathways remains unclear. Using high-confidence proteomics, we identified 850 interactors copurifying with nine NPHP/JBTS/MKS proteins and discovered three connected modules: “NPHP1-4-8” functioning at the apical surface, “NPHP5-6” at centrosomes, and “MKS” linked to Hedgehog signaling. Assays for ciliogenesis and epithelial morphogenesis in 3D renal cultures link renal cystic disease to apical organization defects, whereas ciliary and Hedgehog pathway defects lead to retinal or neural deficits. Using 38 interactors as candidates, linkage and sequencing analysis of 250 patients identified
ATXN10 and
TCTN2 as new NPHP-JBTS genes, and our
Tctn2 mouse knockout shows neural tube and Hedgehog signaling defects. Our study further illustrates the power of linking proteomic networks and human genetics to uncover critical disease pathways.
Display omitted
► High-confidence proteomics identifies an NPHP-JBTS-MKS interaction network ► Three connected modules at apical surface, at centrosomes, or linked to Hh signaling ►
ATXN10 and
TCTN2 are new NPHP-JBTS genes ►
Tctn2 mouse knockout shows neural tube and Hedgehog signaling defects
Display omitted
•New bifunctionalization strategy to obtain GO chemically functionalized with NH2/NH3+ (BFGO).•Bifunctionalization mechanism using N-isopropylidene-3-aminopropyl-triethoxysilane is ...disclosed.•Epoxy Resin/BFGO exhibited hydrophobic contact angles (θ = 105°) and dual corrosion protection.•The synthesis technique promotes smart multifunctional materials with exceptional properties.
Graphene oxide bifunctionalized with NH2/NH3+ (BFGO) is presented here. Further, its potential application to produce smart nanocomposite coatings (Epoxy Resin-BFGO) with hydrophobic and dual corrosion protection (active-passive) is demonstrated. The underlying bifunctionalization mechanisms were disclosed for the first time, in which graphene oxide was covalently functionalized using N-isopropylidene-3-aminopropyl-triethoxysilane (ITES) by microwave irradiation. The bifunctionalization is produced when the imine is protonated (amine deprotection) under acidic conditions, leading to BFGO with NH2:NH3+ groups (atomic ratio = 43:57) confirmed by XPS. Nanocomposites based on Epoxy Resin/BFGO exhibited hydrophobic contact angles (θ = 105°) and outstanding passive-active protection against corrosion for A36 mild steel (A36MS) in a saline solution (1 M ≅ 58.4 g/L). These smart nanocomposite coatings exhibited a corrosion current density (icorr) diminished in around 5 orders of magnitude (icorr = 3.89 E−08 mA/cm2) compared to A36MS coated with neat Epoxy Resin (icorr = 2.34 E−03 mA/cm2). Furthermore, Epoxy Resin-BFGO showed a more noble corrosion potential value (Ecorr = −158 mV) and the lowest corrosion rate (CR = 4.57 E−07 mm/year).
Objective
To assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar.
Background
...Myocardial repair is a promising treatment for patients with MI. The AGTP is a cardiac reparative therapy that reduces infarct size and improves cardiac function. The impact of AGTP on arrhythmogenesis has not been addressed.
Methods
MI was induced in 20 swine. Contrast-enhanced magnetic resonance (ce-MRI), electrophysiological study (EPS), and left-ventricular endocardial high-density mapping were performed 15 days post-MI. Animals were randomized 1:1 to AGTP or sham-surgery group and monitored with ECG-Holter. Repeat EPS, endocardial mapping, and ce-MRI were performed 30 days post-intervention. Myocardial SERCA2, Connexin-43 (Cx43), Ryanodine receptor-2 (RyR2), and cardiac troponin-I (cTnI) gene and protein expression were evaluated.
Results
The AGTP group showed a significant reduction of the total infarct scar, border zone and dense scar mass by ce-MRI (
p
= 0.04), and a decreased total scar and border zone area in bipolar voltage mapping (
p
< 0.001). AGTP treatment significantly reduced the area of very-slow conduction velocity (<0.2 m/s) (
p
= 0.002), the number of deceleration zones (
p
= 0.029), and the area of fractionated electrograms (
p
= 0.005). No differences were detected in number of induced or spontaneous ventricular arrhythmias at EPS and Holter-monitoring. SERCA2, Cx43, and RyR2 gene expression were decreased in the infarct core of AGTP-treated animals (
p
= 0.021,
p
= 0.018,
p
= 0.051, respectively).
Conclusion
AGTP is a safe reparative therapy in terms of arrhythmic risk and provides additional protective effect against adverse electrophysiological remodeling in ischemic heart disease.
PDF
