Objective
To evaluate the efficacy and safety of a plasma-derived factor VIII concentrate containing von Willebrand Factor (pdVWF/FVIII) in standard clinical practice in von Willebrand Disease (VWD) ...patients.
Methods
A retrospective, multicentric, observational study of VWD patients treated with Fanhdi®, a pdVWF/FVIII concentrate, from January 2011 to December 2017 was conducted at 14 centers in Spain. Efficacy and safety were evaluated for acute bleeding episodes, for prevention of bleeding in surgeries, and for secondary long-term prophylaxis.
Results
Seventy-two eligible patients, type 1, 2, 3 VWD (25%/38.9%/36.1%) were treated for spontaneous and traumatic bleeding (140 episodes, n = 41 patients), to prevent surgical bleeding (69 episodes, n = 43 patients); and for secondary long-term prophylaxis (18 programs, n = 13 patients). Replacement therapy with pdVWF/FVIII showed an excellent to good clinical efficacy in 96.7% of the bleeding episodes, 100% during surgical procedures and 100% during prophylaxis. No adverse events (AEs), nor serious AEs related to the product were observed.
Conclusions
Fanhdi® was effective, safe and well tolerated in the management of bleeding episodes, the prevention of bleeding during surgeries, and for secondary long-term prophylaxis in VWD patients.
La teoría de la Inteligencia Emocional, refiere la importancia de las emociones para la solución de las situaciones que impone la vida y en el ámbito educativo se deriva de la necesidad de educar ...integralmente, considerando todas las dimensiones del ser. El objetivo del artículo fue revisar el nivel de reconocimiento que tiene la inteligencia emocional como parte integral del proceso formativo integral de los estudiantes, un estudio de diseño documental producto de analizar 18 unidades de estudio con actores vinculados al contexto educativo. Su análisis fue realizado de manera deductiva, considerando los aportes de autores, la discusión y los resultados. Los hallazgos evidenciaron que la inteligencia emocional forma parte del desarrollo cognitivo de los estudiantes y su adecuada gestión favorece los entornos de procesos académicos. Igualmente, esta es una herramienta indispensable en el proceso de enseñanza y aprendizaje e importante para el desarrollo de la misma en el profesorado.
ABSTRACT
The theory of Emotional Intelligence refers to the importance of emotions for the solution of situations that life imposes and in the educational field it derives from the need to educate comprehensively, considering all dimensions of being. The objective of the article was to review the level of recognition that emotional intelligence has as an integral part of the comprehensive training process of students, a documentary design study product of analyzing 18 study units with actors linked to the educational context. Its analysis was carried out in a deductive way, considering the contributions of the authors, the discussion and the results. The findings showed that emotional intelligence is part of the cognitive development of students and its proper management favors academic process environments. Likewise, this is an indispensable tool in the teaching and learning process and important for its development in teachers.
Key words: Emotional Intelligence, Intelligence, Emotions, Education, Comprehensive Training
RESUMO
A teoria da Inteligência Emocional refere-se à importância das emoções para a solução das situações que a vida impõe e no campo educacional deriva da necessidade de educar de forma integral, considerando todas as dimensões do ser. O objetivo do artigo foi revisar o nível de reconhecimento que a inteligência emocional tem como parte integrante do processo de formação integral dos alunos, um estudo de design documental produto da análise de 18 unidades de estudo com atores vinculados ao contexto educacional. Sua análise foi realizada de forma dedutiva, considerando as contribuições dos autores, a discussão e os resultados. Os achados mostraram que a inteligência emocional faz parte do desenvolvimento cognitivo dos alunos e seu manejo adequado favorece ambientes de processos acadêmicos. Da mesma forma, esta é uma ferramenta indispensável no processo de ensino e aprendizagem e importante para o seu desenvolvimento nos professores.
Palavras-chave: Inteligência Emocional, Inteligência, Emoções, Educação, Formação Integral
RÉSUMÉ
La théorie de l'intelligence émotionnelle fait référence à l'importance des émotions pour la solution des situations que la vie impose et dans le domaine éducatif, elle découle de la nécessité d'éduquer de manière globale, en tenant compte de toutes les dimensions de l'être. L'objectif de l'article était d'examiner le niveau de reconnaissance de l'intelligence émotionnelle en tant que partie intégrante du processus de formation intégrale des étudiants, une étude de conception documentaire produit de l'analyse de 18 unités d'étude avec des acteurs liés au contexte éducatif. Son analyse a été menée de manière déductive, compte tenu des contributions des auteurs, de la discussion et des résultats. Les résultats ont montré que l'intelligence émotionnelle fait partie du développement cognitif des étudiants et que sa bonne gestion favorise les environnements de processus académiques. De même, c'est un outil indispensable dans le processus d'enseignement et d'apprentissage et important pour son développement chez les enseignants.
Mots-clés: Intelligence émotionnelle, Intelligence, Émotions, Éducation, Formation complète
In this work we evaluated the incidence of social skills: empathy, assertiveness, teamwork and self-esteem in the academic performance of students the sixth grade. The research is part of a mixed ...approach (Creswell, 2009) since it combines quantitative and qualitative research methods and techniques. 155 sixth grade students from two institutions of the municipality of Sincelejo formed the sample. The results show that the level of development of social work skills teamwork and assertiveness are by quite heterogeneous both intra as inter groups, i.e., their level of development is a clear trend in none of the two groups, while it self-esteem and empathy have a tendency from developed to well-developed. We found a statistically significant association between the performances achieved by the students in the areas of mathematics and natural sciences, with the institution where they came from, which means that the qualifications of students from each institution tended to gather around the same levels of performance, but differentiable among the group, slightly better for the private institution. In addition, the academic performance of students in the areas of mathematics and natural sciences, keep some relation with the State of development of self-esteem and empathy skills.
There is controversy as to whether the risk of relevant infection in IBD is related to immunosuppressants or the disease itself. The aims of this study were to evaluate: 1 the life-long prevalence ...and types of relevant infections in patients with IBD related to immunosuppressive treatment, and 2 the relationship of both infection and patient comorbidity to mortality.
Observational multicentre retrospective study of IBD patients that presented a relevant infection. For each case, four periods of infection exposure were analysed: P1: pre-IBD diagnosis, P2: from IBD diagnosis to immunosuppressant initiation, P3: during immunosuppressant therapy, and P4: after treatment withdrawal.
The life-long prevalence of relevant infection in the total cohort of patients 6914 was 3%, and 5% in immunosuppressed patients 4202. 366 relevant infections were found in 212 patients P1: 9, P2: 17, P3: 334, and P4: 6. Differences between periods were significant p < 0.0001. The most frequent types of infection were respiratory, intestinal and urinary. The most frequent opportunistic infections were tuberculosis prevalence: 2.6/1000 and herpes zoster prevalence: 3.9/1000. Herpes zoster infection was associated with thiopurines alone or in combination with anti-TNF in 75% of the cases, whereas tuberculosis was associated with anti-TNF in 94% of patients. The overall mortality was 4.2%. Infection-related mortality was 2.8% and it was not influenced by comorbidity.
Relevant infections in IBD patients are rare and appear to be related to immunosuppression. Relevant infection is a major cause of death in IBD.
The prevalence of penetrating complications in Crohn's disease (CD) increases progressively over time, but evidence on the medical treatment in this setting is limited. The aim of this study was to ...evaluate the effectiveness of biologic agents in CD complicated with internal fistulizing disease.
Adult patients with CD-related fistulae who received at least 1 biologic agent for this condition from the prospectively maintained ENEIDA registry were included. Exclusion criteria involved those receiving biologics for perianal disease, enterocutaneous, rectovaginal, anastomotic, or peristomal fistulae. The primary end point was fistula-related surgery. Predictive factors associated with surgery and fistula closure were evaluated by multivariate logistic regression and survival analyses.
A total of 760 patients from 53 hospitals (673 receiving anti-tumor necrosis factors, 69 ustekinumab, and 18 vedolizumab) were included. After a median follow-up of 56 months (interquartile range, 26-102 months), 240 patients required surgery, with surgery rates of 32%, 41%, and 24% among those under anti-tumor necrosis factor, vedolizumab, or ustekinumab, respectively. Fistula closure was observed in 24% of patients. Older patients, ileocolonic disease, entero-urinary fistulae, or an intestinal stricture distal to the origin of the fistula were associated with a higher risk of surgery, whereas nonsmokers and combination therapy with an immunomodulator reduced this risk.
Biologic therapy is beneficial in approximately three-quarters of patients with fistulizing CD, achieving fistula closure in 24%. However, around one-third still undergo surgery due to refractory disease. Some patient- and lesion-related factors can identify patients who will obtain more benefit from these drugs.
Control de daños en cirugía general Guerrero Rodríguez, María Elena; Proaño Sánchez, Mónica Elizabeth; Montufar Benítez, Olga Italia ...
RECIAMUC,
01/2023, Letnik:
7, Številka:
1
Journal Article
La cirugía de control de daños (CCD) es un recurso importante en pacientes inestables y potencialmente graves, actualmente esta estrategia quirúrgica es empleada también en determinados pacientes con ...patología quirúrgica urgente de origen séptico no traumático que condiciona una situación crítica de inestabilidad hemodinámica. La metodología utilizada para el presente trabajo de investigación, se enmarca dentro de una revisión bibliográfica de tipo documental. La técnica para la recolección de datos está constituida por materiales electrónicos, estos últimos como Google Académico, PubMed, Science direct, entre otros, apoyándose para ello en el uso de descriptores en ciencias de la salud o terminología MESH. La información aquí obtenida será revisada para su posterior análisis. El beneficio de este procedimiento radica en la realización de laparotomías en un solo acto quirúrgico en lo que respecta a pacientes politraumatizados, con el objetivo de restaurar y mantener las condiciones del paciente altamente traumatizado, con altas probabilidades de éxito y supervivencia, salvo que estos entren en la llamada triada de la muerte.
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