Cryptography is essential for the security of online communication, cars and implanted medical devices. However, many commonly used cryptosystems will be completely broken once large quantum ...computers exist. Post-quantum cryptography is cryptography under the assumption that the attacker has a large quantum computer; post-quantum cryptosystems strive to remain secure even in this scenario. This relatively young research area has seen some successes in identifying mathematical operations for which quantum algorithms offer little advantage in speed, and then building cryptographic systems around those. The central challenge in post-quantum cryptography is to meet demands for cryptographic usability and flexibility without sacrificing confidence.
An abundance of data has provided insight into the mechanisms underlying the development of left ventricular (LV) hypertrophy and its progression to LV failure. In contrast, there is minimal data on ...the adaptation of the right ventricle (RV) to pressure and volume overload and the transition to RV failure. This is a critical clinical question, because the RV is uniquely at risk in many patients with repaired or palliated congenital heart disease and in those with pulmonary hypertension. Standard heart failure therapies have failed to improve function or survival in these patients, suggesting a divergence in the molecular mechanisms of RV versus LV failure. Although, on the cellular level, the remodeling responses of the RV and LV to pressure overload are largely similar, there are several key differencesthe stressed RV is more susceptible to oxidative stress, has a reduced angiogenic response, and is more likely to activate cell death pathways than the stressed LV. Together, these differences could explain the more rapid progression of the RV to failure versus the LV. This review will highlight known molecular differences between the RV and LV responses to hemodynamic stress, the unique stressors on the RV associated with congenital heart disease, and the need to better understand these molecular mechanisms if we are to develop RV-specific heart failure therapeutics.
Participants ranging in age from 3 to 98 years (N = 708; approximately 60% female; 49% Caucasian, 38% Asian; 12% Other ethnicities, 1% Indigenous; modal household income > $80,000) completed a ...battery of tasks involving verbal ability, executive function, and perspective-taking. Wherever possible, all participants completed the same version of a task. The current study tested hindsight bias and false-belief reasoning to determine how these constructs relate to each other across the child-to-adult life span. Participants of all ages showed robust hindsight bias and false-belief reasoning errors. Hindsight bias followed a U-shaped function, wherein preschoolers and older adults showed more hindsight bias than older children and younger adults. False-belief reasoning, conversely, was relatively constant from preschool to older adulthood. Hindsight bias did not correlate with false-belief reasoning. We conclude that hindsight bias and false-belief reasoning errors are robust but unrelated cognitive biases across the life span.
Cryptographic Competitions Bernstein, Daniel J.
Journal of cryptology,
03/2024, Letnik:
37, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Competitions are widely viewed as the safest way to select cryptographic algorithms. This paper surveys procedures that have been used in cryptographic competitions, and analyzes the extent to which ...those procedures reduce security risks.
This paper explains the design and implementation of a high-security elliptic-curve-Diffie-Hellman function achieving record-setting speeds: e.g., 832457 Pentium III cycles (with several side ...benefits: free key compression, free key validation, and state-of-the-art timing-attack protection), more than twice as fast as other authors’ results at the same conjectured security level (with or without the side benefits).
Metacognitive hindsight bias Ackerman, Rakefet; Bernstein, Daniel M.; Kumar, Ragav
Memory & cognition,
07/2020, Letnik:
48, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Hindsight bias (HB) is the tendency to see known information as obvious. We studied metacognitive hindsight bias (MC-HB)—a shift away from one’s original confidence regarding answers provided before ...learning the actual facts. In two experiments, participants answered general-knowledge questions in social scenarios and provided their confidence in each answer. Subsequently, they learned answers to half the questions and then recalled their initial answers and confidence. Finally, they reanswered, as a learning check. We measured confidence accuracy by calibration (over/underconfidence) and resolution (discrimination between incorrect and correct answers), expecting them to improve in hindsight. In both experiments, participants displayed robust HB and MC-HB for resolution despite attempts to recall the initial confidence in one’s answer. In Experiment
2
, promising anonymity to participants eliminated MC-HB, while social scenarios produced MC-HB for both resolution and calibration—indicative of overconfidence. Overall, our findings highlight that in social contexts, recall of confidence in hindsight is more consistent with answers’ accuracy than confidence initially was. Social scenarios differently affect HB and MC-HB, thus dissociating these two biases.
•Stimulus size affected perceptual fluency.•In turn, perceptual fluency increased judgments of learning.•Beliefs about memory cannot account for this size effect.•Fluency is an important factor in ...metacognitive judgments.
Studies have demonstrated that perceptual fluency—the ease of perceiving stimuli—does not contribute to higher predictions of future memory performance (judgments of learning; JOLs) for words presented in a larger font (48pt) than for words presented in a smaller font (18pt). Here, we investigated whether stimulus size can affect JOLs through another mode of perceptual fluency. We presented stimuli that were initially so small as to be entirely unrecognizable but that gradually increased in size. Stimuli were pictures of common objects (Experiment 1), faces (Experiment 2), and words (Experiments 3 and 4). People indicated when they could identify the stimulus and then made a JOL. The time required for participants to identify each stimulus was our measure of perceptual fluency. In Experiments 1 to 3, we manipulated the speed of the clarification process across trials. Results showed that the less time it took to identify the clarifying stimuli, independent of clarification speed, the higher one’s JOLs. Moreover, fast clarification increased JOLs indirectly by decreasing identification time. In Experiment 4, one group of participants (learner group) could base JOLs on both perceptual fluency and beliefs about how stimulus size affects memory performance, while the other group (observer group) could base JOLs only on beliefs. Inverse relations between identification time and JOLs occurred only in the learner group. These results demonstrate that perceptual fluency may produce size effects on JOLs and support the idea that fluency is an important factor in JOLs.
BACKGROUND AND PURPOSE:The diverse causes of right-sided heart failure (RHF) include, among others, primary cardiomyopathies with right ventricular (RV) involvement, RV ischemia and infarction, ...volume loading caused by cardiac lesions associated with congenital heart disease and valvular pathologies, and pressure loading resulting from pulmonic stenosis or pulmonary hypertension from a variety of causes, including left-sided heart disease. Progressive RV dysfunction in these disease states is associated with increased morbidity and mortality. The purpose of this scientific statement is to provide guidance on the assessment and management of RHF.
METHODS:The writing group used systematic literature reviews, published translational and clinical studies, clinical practice guidelines, and expert opinion/statements to summarize existing evidence and to identify areas of inadequacy requiring future research. The panel reviewed the most relevant adult medical literature excluding routine laboratory tests using MEDLINE, EMBASE, and Web of Science through September 2017. The document is organized and classified according to the American Heart Association to provide specific suggestions, considerations, or reference to contemporary clinical practice recommendations.
RESULTS:Chronic RHF is associated with decreased exercise tolerance, poor functional capacity, decreased cardiac output and progressive end-organ damage (caused by a combination of end-organ venous congestion and underperfusion), and cachexia resulting from poor absorption of nutrients, as well as a systemic proinflammatory state. It is the principal cause of death in patients with pulmonary arterial hypertension. Similarly, acute RHF is associated with hemodynamic instability and is the primary cause of death in patients presenting with massive pulmonary embolism, RV myocardial infarction, and postcardiotomy shock associated with cardiac surgery. Functional assessment of the right side of the heart can be hindered by its complex geometry. Multiple hemodynamic and biochemical markers are associated with worsening RHF and can serve to guide clinical assessment and therapeutic decision making. Pharmacological and mechanical interventions targeting isolated acute and chronic RHF have not been well investigated. Specific therapies promoting stabilization and recovery of RV function are lacking.
CONCLUSIONS:RHF is a complex syndrome including diverse causes, pathways, and pathological processes. In this scientific statement, we review the causes and epidemiology of RV dysfunction and the pathophysiology of acute and chronic RHF and provide guidance for the management of the associated conditions leading to and caused by RHF.
This paper presents a fast method to compute algebraic norms of integral elements of smooth-degree cyclotomic fields, and, more generally, smooth-degree Galois number fields with commutative Galois ...groups. The typical scenario arising in
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operation count was already known in two easier special cases: norms from power-of-2 cyclotomic fields via towers of power-of-2 cyclotomic subfields, and norms from multiquadratic fields via towers of multiquadratic subfields. This paper handles more general Abelian fields by identifying tower-compatible integral bases supporting fast multiplication; in particular, there is a synergy between tower-compatible Gauss-period integral bases and a fast-multiplication idea from Rader.
As a baseline, this paper also analyzes various standard norm-computation techniques that apply to arbitrary number fields, concluding that all of these techniques use at least
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Mitochondrial dysfunction is a key contributor to septic cardiomyopathy. Although recent literature implicates dynamin related protein 1 (Drp1) and its mitochondrial adaptor fission 1 (Fis1) in the ...development of pathologic fission and mitochondrial failure in neurodegenerative disease, little is known about the role of Drp1/Fis1 interaction in the context of sepsis-induced cardiomyopathy. Our study tests the hypothesis that Drp1/Fis1 interaction is a major driver of sepsis-mediated pathologic fission, leading to mitochondrial dysfunction in the heart.
H9C2 cardiomyocytes were treated with lipopolysaccharide (LPS) to evaluate changes in mitochondrial membrane potential, oxidative stress, cellular respiration, and mitochondrial morphology. Balb/c mice were treated with LPS, cardiac function was measured by echocardiogaphy, and mitochondrial morphology determined by electron microscopy (EM). Drp1/Fis1 interaction was inhibited by P110 to determine whether limiting mitochondrial fission can reduce LPS-induced oxidative stress and cardiac dysfunction.
LPS-treated H9C2 cardiomyocytes demonstrated a decrease in mitochondrial respiration followed by an increase in mitochondrial oxidative stress and a reduction in membrane potential. Inhibition of Drp1/Fis1 interaction with P110 attenuated LPS-mediated cellular oxidative stress and preserved membrane potential. In vivo, cardiac dysfunction in LPS-treated mice was associated with increased mitochondrial fragmentation. Treatment with P110 reduced cardiac mitochondrial fragmentation, prevented decline in cardiac function, and reduced mortality.
Sepsis decreases cardiac mitochondrial respiration and membrane potential while increasing oxidative stress and inducing pathologic fission. Treatment with P110 was protective in both in vitro and in vivo models of septic cardiomyopathy, suggesting a key role of Drp1/Fis1 interaction, and a potential target to reduce its morbidity and mortality.
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