Background
To evaluate changes in airway dimensions following mandibular setback with conventional orthognathic approach (COA) and surgery-first orthognathic approach (SFOA).
Materials and Methods
...Treatment records of 20 patients who underwent mandibular setback with SFOA/COA were divided into two groups (COA and SFOA, ten patients in each group). Acoustic pharyngometry values were obtained at T0 (01 week prior to surgery), T1 (01-month post-surgery) and T2 (01-year post-surgery). Percentage change in mean volume and area was obtained at T1 (T1–T0) to evaluate airway changes and at T2 (T2–T1) to compare relapse of airway changes in both groups. Changes in airway per mm setback at T1 (T1–T0) and T2 (T2–T1) were also obtained in both groups.
Results
For both parameters, SFOA showed greater reduction at T1 and greater relapse at T2 as compared to COA. The reduction in airway volume at T1 was 0.56 mm/mm setback in COA compared to 1.06 mm/mm setback in SFOA (
P
-value > 0.05). The relapse in airway volume at T2 was 0.15 mm/mm setback in COA compared to 0.25 mm/mm setback in SFOA (
P
-value > 0.05). The reduction in area at T1 was 0.062 mm/mm setback in COA compared to 0.110 mm/mm setback in SFOA (
P
-value > 0.05). The relapse in area at T2 was 0.016 mm/mm setback in COA compared to 0.034/mm setback in SFOA (
P
-value < 0.05).
Conclusion
In setback cases, SFOA has greater airway reduction immediate post-surgically and greater relapse at 01-year follow-up. Predicting these changes at diagnostic and treatment planning stage may prevent potential adverse events on airway.
Background
We report the first evidence of sympatric distribution of Plasmodium ovale curtisi and P. ovale wallikeri from India.
Methods
Fingerprick blood samples were collected from fever cases in ...district Bastar, Chhattisgarh State for malaria screening by microscopy and PCR.
Results
Two cases of mono infection of P. ovale, and a fatal case of cerebral malaria with a mixed infection of P. vivax, P. falciparum and P. ovale were confirmed by PCR. Sequencing analysis revealed the presence of P. ovale curtisi and P. ovale wallikeri.
Conclusions
This study highlights the need of molecular diagnosis of malaria cases in forested areas for treatment and control.
Forensic odontology: The prosthetic ID Prakash, Poonam; Singh, Kirandeep; Bhandari, S
Journal of forensic dental sciences,
09/2019, Letnik:
11, Številka:
3
Journal Article
Recenzirano
Odprti dostop
The term "forensic science" involves forensic (or forensis, in Latin), which means a public discussion or debate. In a more modern context, however, forensic applies to courts or the judicial system. ...Combine that with science, and forensic science means applying scientific methods and processes to solving crimes. People can be identified by their fingerprints, foot creases, and from traces of their DNA from blood, skin, hair, saliva, and semen by DNA analysis. However, in situations where these records are unavailable or unusable due to the nature of the disaster, the dental records and aids prove to be useful for victim identification. This article aims at highlighting the importance of the dental records and the forensic odontology in the accurate and efficient identification of the conflict victims or deceased to serve as an important adjunct to the forensic medicine in a simplified manner.
Atypical hemolytic uremic syndrome (aHUS) is a rare cause of end-stage kidney disease and associated with poor outcomes after kidney transplantation from early disease recurrence. Prophylactic ...eculizumab treatment at the time of transplantation is used in selected patients with aHUS. We report a retrospective case note review describing transplant outcomes in patients with aHUS transplanted between 1978 and 2017, including those patients treated with eculizumab.
The National Renal Complement Therapeutics Centre database identified 118 kidney transplants in 86 recipients who had a confirmed diagnosis of aHUS. Thirty-eight kidney transplants were performed in 38 recipients who received prophylactic eculizumab. The cohort not treated with eculizumab comprised 80 transplants in 60 recipients and was refined to produce a comparable cohort of 33 transplants in 32 medium and high-risk recipients implanted since 2002. Complement pathway genetic screening was performed. Graft survival was censored for graft function at last follow-up or patient death. Graft survival without eculizumab treatment is described by complement defect status and by Kidney Disease: Improving Global Outcomes risk stratification.
Prophylactic eculizumab treatment improved renal allograft survival ( P = 0.006) in medium and high-risk recipients with 1-y survival of 97% versus 64% in untreated patients. Our data supports the risk stratification advised by Kidney Disease: Improving Global Outcomes.
Prophylactic eculizumab treatment dramatically improves graft survival making transplantation a viable therapeutic option in aHUS.
We evaluated the effect of raw potato starch (RPS) on growth performance, postweaning diarrhea, and gastrointestinal microbial populations in weaned piglets. Eighty-four piglets were weaned at 17 ± 2 ...d of age with an average BW of 6.0 ± 0.9 kg. Pigs were blocked by BW and assigned to 1 of 4 diets in a randomized complete block design with 7 replicate pens per diet and 3 pigs per pen. Treatments were 1) a positive control (PC) containing an antibiotic, 2) a negative control (NC) with no RPS and no antibiotic, 3) NC + 7% RPS (7% RPS), and 4) NC + 14% RPS (14% RPS). Diets were corn-wheat-soybean meal-based and formulated to meet NRC (1998) recommendations. The ADG, ADFI, and G:F ratio were determined weekly. Fecal consistency (FC) scoring was determined daily. After wk 3, 1 pig with a BW closest to the pen mean was killed to evaluate ileal and colonic mucosal-attached Escherichia coli and lactic acid bacteria, as well as digesta pH, VFA, and ammonia N concentrations. The DNA was extracted from ileum and colon digesta and used for molecular microbial evaluations using terminal-RFLP analysis of 16S rDNA genes. The ADG for wk 1 was greater (P < 0.01) for the PC diet, but diet had no effect on ADG during wk 3. The ADFI did not differ among treatments during the first 2 wk, and ADFI was least for 7% RPS diet during wk 3. The NC diet had a greater (P < 0.05) FC score during wk 1 than other treatments, but diet had no effect on FC score during wk 2 and 3. Diets had no effect on the colon lactic acid bacterial counts; however, the PC diet had decreased (P < 0.05) colon E. coli counts than other treatments. Ileum and colon digesta pH and total VFA concentrations did not differ among treatments. Pigs fed with 7 and 14% RPS diets had greater (P < 0.05) ileum ammonia N concentration compared with pigs fed with other diets. There was more diarrhea (P < 0.05) in the 14% than the 7% RPS and control treatments at d 21. This difference correlated with a decline (P < 0.05) in microbial diversity in the colon. We concluded that 7% RPS can be used to prevent postweaning diarrhea in weaned piglets, but there are no effects on growth performance.
The rice–wheat cropping system, occupying 24 million hectares of the productive area in South Asia and China, is important for food security. Monitoring long-term changes in crop yields and ...identifying the factors associated with such changes are essential to maintain and/or improve crop productivity. Long-term experiments (LTE) provide these opportunities. We analyzed 33 rice–wheat LTE in the Indo-Gangetic Plains (IGP) of South Asia, non-IGP in India, and China to investigate the extent of yield stagnation or decline and identify possible causes of yield decline. In treatments where recommended rates of N, P and K were applied, yields of rice and wheat stagnated in 72 and 85% of the LTE, respectively, while 22 and 6% of the LTE showed a significant (
P<0.05) declining trend for rice and wheat yields, respectively. In the rice–wheat system, particularly in the IGP, rice yields are declining more rapidly than wheat. The causes of yield decline are mostly location-specific but depletion of soil K seems to be a general cause. In over 90% of the LTE, the fertilizer K rates used were not sufficient to sustain a neutral K input–output balance. Depletion of soil C, N and Zn and reduced availability of P, delays in planting, decreases in solar radiation and increases in minimum temperatures are the other potential causes of yield decline. A more efficient, integrated strategy with detailed data collection is required to identify the specific causes of yield decline. Constant monitoring of LTEs and analysis of the data using improved statistical and simulation tools should be done to unravel the cause–effect relationships of productivity and sustainability of rice–wheat systems.
We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years of age, before the introduction of rotavirus vaccines. We identified 117 ...datasets and fit parametric age distributions to each country dataset and mortality stratum. We calculated the median age and the cumulative proportion of rotavirus gastroenteritis events expected to occur at ages between birth and 5.0 years. The median age of rotavirus-positive hospital admissions was 38 weeks (interquartile range IQR, 25-58 weeks) in countries with very high child mortality and 65 weeks (IQR, 40-107 weeks) in countries with very low or low child mortality. In countries with very high child mortality, 69% of rotavirus-positive admissions in children <5 years of age were in the first year of life, with 3% by 10 weeks, 8% by 15 weeks, and 27% by 26 weeks. This information is critical for assessing the potential benefits of alternative rotavirus vaccination schedules in different countries and for monitoring program impact.
A new convenient method has been developed for the synthesis of quinazolinones from 2-phenyl-1
H
-indole and substituted amines under catalysis by chlorosulfonic acid. The target quinazolinones were ...synthesized through a coupling reaction of 2-phenyl-1
H
-indole and different amines using chlorosulfonic acid and hydrogen peroxide in DMSO on heating at 100°C, as well as under microwave irradiation at 80°C. The microwave-assisted synthesis provided excellent yields in 8 min compared to 4–5 h under conventional heating. The developed method is flexible and economical, and it has major importance in industry and academics.
•Experimental measurement of coolant void reactivity.•Measurement of void reactivity in Thorium-Plutonium fuel based experimental cluster.•Measurement of void reactivity for various partial voiding ...conditions.•Comparison of measured void reactivity with theoretically estimated values from deterministic and Monte Carlo based reactor physics codes.
An Advanced Heavy Water Reactor (AHWR) based on thorium fuel is being designed and developed in India. The design has many inherent safety features; the most important among them is its negative coolant void coefficient. An experimental facility, named AHWR Critical Facility, has been built to validate the physics design parameters. Coolant void worth which is an important safety parameter was measured using differential critical height in a thoria based experimental MOX fuel assembly placed in the center of the core. The voiding effects were experimentally determined with both water and high density polyethylene (HDP) coolant. Different fractional voids were obtained using combinations of HDP block of compatible shape and sizes.
The aim of the experiment was to validate the code systems used in physics design and in particular, to assess their capability of modeling the voiding conditions in thorium based fuel cluster. The validation exercise was performed with both deterministic and stochastic methods. The theoretical estimates of the void worth were found in very good agreement with that of the measurement. The results have enhanced the confidence in the code system used for AHWR physics design.
This phase 1 study (Clinicaltrials.gov: NCT00507442) was conducted to determine the maximum tolerated dose (MTD) of cyclophosphamide in combination with bortezomib, dexamethasone and lenalidomide ...(VDCR) and to assess the safety and efficacy of this combination in untreated multiple myeloma patients. Cohorts of three to six patients received a cyclophosphamide dosage of 100, 200, 300, 400 or 500 mg/m(2) (on days 1 and 8) plus bortezomib 1.3 mg/m(2) (on days 1, 4, 8 and 11), dexamethasone 40 mg (on days 1, 8 and 15) and lenalidomide 15 mg (on days 1-14), for eight 21-day induction cycles, followed by four 42-day maintenance cycles (bortezomib 1.3 mg/m(2), on days 1, 8, 15 and 22). The MTD was the cyclophosphamide dose below which more than one of six patients experienced a dose-limiting toxicity (DLT). Twenty-five patients were treated. Two DLTs were seen, of grade 4 febrile neutropenia (cyclophosphamide 400 mg/m(2)) and grade 4 herpes zoster despite anti-viral prophylaxis (cyclophosphamide 500 mg/m(2)). No cumulative hematological toxicity or thromboembolic episodes were reported. The overall response rate was 96%, including 20% stringent complete response (CR), 40% CR/near-complete response and 68% >or=very good partial response. VDCR is well tolerated and highly active in this population. No MTD was reached; the recommended phase 2 cyclophosphamide dose in VDCR is 500 mg/m(2), which was the highest dose tested.
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