The fundamental unit of protein structure is the domain, defined as a region or regions of a polypeptide that folds independently and possesses a hydrophobic core with a hydrophilic exterior (seeNote ...1). Domains, particularly those with enzymatic activities, may possess functions independently of whether they are present in isolation or are part of a larger multidomain protein. Other domains confer regulatory and specificity properties to multidomain proteins, usually via the provision of binding sites. Because the majority of eukaryotic proteins, and a large number of eubacterial and archaeal proteins, are multidomain in character, the determination of the structures and functions of these proteins requires detailed consideration of their domain architectures.
With the sponsorship of ``Fundacio La Caixa'' we met in Barcelona, November
21st and 22nd, to analyze the reasons why, after the completion of the human
genome sequence, the identification all ...protein coding genes and their variants
remains a distant goal. Here we report on our discussions and summarize some of
the major challenges that need to be overcome in order to complete the human
gene catalog.
With the sponsorship of ``Fundacio La Caixa'' we met in Barcelona, November 21st and 22nd, to analyze the reasons why, after the completion of the human genome sequence, the identification all ...protein coding genes and their variants remains a distant goal. Here we report on our discussions and summarize some of the major challenges that need to be overcome in order to complete the human gene catalog.
Journey to the Genetic Interior Hall, Stephen S.; Scientific American; BIRNEY, EWAN
Scientific American,
10/2012, Letnik:
307, Številka:
4
Magazine Article
Hall interviews "Cat herder in chief" of the ENCODE consortium of 400 geneticists from around the world Ewan Britney. Among other things, Britney talks about the ENCODE project.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NMLJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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