On April 1st, 2019, the Advanced Laser Interferometer Gravitational-Wave Observatory (aLIGO), joined by the Advanced Virgo detector, began the third observing run, a year-long dedicated search for ...gravitational radiation. The LIGO detectors have achieved a higher duty cycle and greater sensitivity to gravitational waves than ever before, with LIGO Hanford achieving angle-averaged sensitivity to binary neutron star coalescences to a distance of 111 Mpc, and LIGO Livingston to 134 Mpc with duty factors of 74.6% and 77.0% respectively. The improvement in sensitivity and stability is a result of several upgrades to the detectors, including doubled intracavity power, the addition of an in-vacuum optical parametric oscillator for squeezed-light injection, replacement of core optics and end reaction masses, and installation of acoustic mode dampers. This paper explores the purposes behind these upgrades, and explains to the best of our knowledge the noise currently limiting the sensitivity of each detector.
The Advanced LIGO detectors have recently completed their second observation run successfully. The run lasted for approximately 10 months and led to multiple new discoveries. The sensitivity to ...gravitational waves was partially limited by laser noise. Here, we utilize auxiliary sensors that witness these correlated noise sources, and use them for noise subtraction in the time domain data. This noise and line removal is particularly significant for the LIGO Hanford Observatory, where the improvement in sensitivity is greater than 20%. Consequently, we were also able to improve the astrophysical estimation for the location, masses, spins, and orbital parameters of the gravitational wave progenitors.
MAXI J1836−194 is a Galactic black hole candidate X-ray binary that was discovered in 2011 when it went into outburst. In this paper, we present the full radio monitoring of this system during its ...‘failed’ outburst, in which the source did not complete a full set of state changes, only transitioning as far as the hard intermediate state. Observations with the Karl G. Jansky Very Large Array (VLA) and Australia Telescope Compact Array (ATCA) show that the jet properties changed significantly during the outburst. The VLA observations detected linearly polarized emission at a level of ∼1 per cent early in the outburst, increasing to ∼3 per cent as the outburst peaked. High-resolution images with the Very Long Baseline Array (VLBA) show an ∼15 mas jet along the position angle −21 ± 2°, in agreement with the electric vector position angle found from our polarization results (−21 ± 4°), implying that the magnetic field is perpendicular to the jet. Astrometric observations suggest that the system required an asymmetric natal kick to explain its observed space velocity. Comparing quasi-simultaneous X-ray monitoring with the 5 GHz VLA observations from the 2011 outburst shows an unusually steep hard-state radio/X-ray correlation of
$L_{\rm R} \propto L_{\rm X}^{1.8\pm 0.2}$
, where L
R and L
X denote the radio and X-ray luminosities, respectively. With ATCA and Swift monitoring of the source during a period of re-brightening in 2012, we show that the system lay on the same steep correlation. Due to the low inclination of this system, we then investigate the possibility that the observed correlation may have been steepened by variable Doppler boosting.
NeuPSIG guidelines on neuropathic pain assessment Haanpää, Maija; Attal, Nadine; Backonja, Miroslav ...
Pain (Amsterdam),
January 2011, 2011-Jan, 2011-01-00, 20110101, 2011, Letnik:
152, Številka:
1
Journal Article
Recenzirano
This is a revision of guidelines, originally published in 2004, for the assessment of patients with neuropathic pain. Neuropathic pain is defined as pain arising as a direct consequence of a lesion ...or disease affecting the somatosensory system either at peripheral or central level.
Screening questionnaires are suitable for identifying potential patients with neuropathic pain, but further validation of them is needed for epidemiological purposes. Clinical examination, including accurate sensory examination, is the basis of neuropathic pain diagnosis. For more accurate sensory profiling, quantitative sensory testing is recommended for selected cases in clinic, including the diagnosis of small fiber neuropathies and for research purposes.
Measurement of trigeminal reflexes mediated by A-beta fibers can be used to differentiate symptomatic trigeminal neuralgia from classical trigeminal neuralgia. Measurement of laser-evoked potentials is useful for assessing function of the A-delta fiber pathways in patients with neuropathic pain. Functional brain imaging is not currently useful for individual patients in clinical practice, but is an interesting research tool. Skin biopsy to measure the intraepidermal nerve fiber density should be performed in patients with clinical signs of small fiber dysfunction.
The intensity of pain and treatment effect (both in clinic and trials) should be assessed with numerical rating scale or visual analog scale. For future neuropathic pain trials, pain relief scales, patient and clinician global impression of change, the proportion of responders (50% and 30% pain relief), validated neuropathic pain quality measures and assessment of sleep, mood, functional capacity and quality of life are recommended.
The role of MerTK, a member of the Tyro3-Axl-MerTK family of receptor tyrosine kinase, in the immune response to radiation therapy (RT) is unclear. We investigated immune-mediated tumor control after ...RT in murine models of colorectal and pancreatic adenocarcinoma using MerTK wild-type and knock-out hosts and whether inhibition of MerTK signaling with warfarin could replicate MerTK knock-out phenotypes.
Wild-type and MerTK
BALB/c mice were grafted in the flanks with CT26 tumors and treated with computed tomography guided RT. The role of macrophages and CD8 T cells in the response to radiation were demonstrated with cell depletion studies. The role of MerTK in priming immune responses after RT alone and with agonist antibodies to the T cell costimulatory molecule OX40 was evaluated in a Panc02-SIY model antigen system. The effect of warfarin therapy on the in-field and abscopal response to RT was demonstrated in murine models of colorectal adenocarcinoma. The association between warfarin and progression-free survival for patients treated with SABR for early-stage non-small cell lung cancer was evaluated in a multi-institutional retrospective study.
MerTK
hosts had better tumor control after RT compared with wild-type mice in a macrophage and CD8 T cell-dependent manner. MerTK
mice showed increased counts of tumor antigen-specific CD8 T cells in the peripheral blood after tumor-directed RT alone and in combination with agonist anti-OX40. Warfarin therapy phenocopied MerTK
for single-flank tumors treated with RT and improved abscopal responses for RT combined with anti-CTLA4. Patients on warfarin therapy when treated with SABR for non-small cell lung cancer had higher progression-free survival rates compared with non-warfarin users.
MerTK inhibits adaptive immune responses after SABR. Because warfarin inhibits MerTK signaling and phenocopies genetic deletion of MerTK in mice, warfarin therapy may have beneficial effects in combination with SABR and immune therapy in patients with cancer.
In 2015 and 2016, the AfriSAR campaign was carried out as a collaborative effort among international space and National Park agencies (ESA, NASA, ONERA, DLR, ANPN and AGEOS) in support of the ...upcoming ESA BIOMASS, NASA-ISRO Synthetic Aperture Radar (NISAR) and NASA Global Ecosystem Dynamics Initiative (GEDI) missions. The NASA contribution to the campaign was conducted in 2016 with the NASA LVIS (Land Vegetation and Ice Sensor) Lidar, the NASA L-band UAVSAR (Uninhabited Aerial Vehicle Synthetic Aperture Radar). A central motivation for the AfriSAR deployment was the common AGBD estimation requirement for the three future spaceborne missions, the lack of sufficient airborne and ground calibration data covering the full range of ABGD in tropical forest systems, and the intercomparison and fusion of the technologies.
During the campaign, over 7000 km2 of waveform Lidar data from LVIS and 30,000 km2 of UAVSAR data were collected over 10 key sites and transects. In addition, field measurements of forest structure and biomass were collected in sixteen 1-hectare sized plots. The campaign produced gridded Lidar canopy structure products, gridded aboveground biomass and associated uncertainties, Lidar based vegetation canopy cover profile products, Polarimetric Interferometric SAR and Tomographic SAR products and field measurements. Our results showcase the types of data products and scientific results expected from the spaceborne Lidar and SAR missions; we also expect that the AfriSAR campaign data will facilitate further analysis and use of waveform lidar and multiple baseline polarimetric SAR datasets for carbon cycle, biodiversity, water resources and more applications by the greater scientific community.
•In 2016, the international collaborative air and field campaign AfriSAR took place•The data provides calibration and validation for NASA GEDI, NISAR and ESA BIOMASS•NASA collected coincident L-band SAR (UAVSAR) and waveform Lidar (LVIS) data•We produced SAR- and Lidar derived canopy height, biomass and vertical profile datasets•We provide an overview of the airborne mission, data products and applications
Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes ...neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and depolarize at lower calcium loads than do mitochondria from controls. We found a similar defect in brain mitochondria from transgenic mice expressing full-length mutant huntingtin, and this defect preceded the onset of pathological or behavioral abnormalities by months. By electron microscopy, we identified N-terminal mutant huntingtin on neuronal mitochondrial membranes, and by incubating normal mitochondria with a fusion protein containing an abnormally long polyglutamine repeat, we reproduced the mitochondrial calcium defect seen in human patients and transgenic animals. Thus, mitochondrial calcium abnormalities occur early in HD pathogenesis and may be a direct effect of mutant huntingtin on the organelle.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Devic’s disease is often considered as a variant of multiple sclerosis (MS). However, evidence suggests that Devic’s disease may be distinct from MS. Devic’s disease can coexist with connective ...tissue diseases, particularly Sjögren’s disease, but this association is rare with MS. Diagnosis of Sjögren’s disease in patients with neurological symptoms is often difficult. During early stages of Sjögren’s disease, patients may not fulfill all criteria for Sjögren’s disease. A high percentage of patients with Sjögren’s disease have inflammatory infiltrates in minor salivary glands, and this may be a reliable indicator of early or subclinical disease. We show high prevalence (80%) of salivary gland inflammation in Devic’s disease and longitudinally extensive transverse myelitis (LETM). We diagnosed 16 patients with Devic’s disease, and 2 of these satisfied criteria for Sjögren’s disease as did 2 of 9 patients with LETM. Anti-SSA/B titers were infrequently elevated. Although most did not satisfy criteria for Sjögren’s disease. 9 of 12 Devic’s disease patients and 7 of 8 LETM patients had severe salivary gland inflammation. Thus: (1) patients with Devic’s disease or with LETM who have positive labial biopsies but do not satisfy criteria for Sjögren’s disease could have subclinical Sjögren’s diseases. Alternatively, (2) as patients with Devic’s disease have elevated titers of several autoantibodies, so there may exist a set of antibodies that react with antigens in minor salivary glands and cause inflammation. Minor salivary gland biopsy is more sensitive than anti-SSA/B serology in providing histological evidence for possible Sjögren’s disease with CNS lesions.
This study characterized the AIDS epidemic among urban men who have sex with men (MSM).
A probability sample of MSM was obtained in 1997 (n = 2881; 18 years and older) from New York, Los Angeles, ...Chicago, and San Francisco, and HIV status was determined through self-report and biological measures.
HIV prevalence was 17% (95% confidence interval = 15%, 19%) overall, with extremely high levels in African Americans (29%), MSM who used injection drugs (40%), "ultraheavy" noninjection drug users (32%), and less educated men (< high school, 37%). City-level HIV differences were non-significant once these other factors were controlled for. In comparing the present findings with historical data based on public records and modeling, HIV prevalence appears to have declined as a result of high mortality (69%) and stable, but high, incidence rates (1%-2%).
Although the findings suggest that HIV prevalence has declined significantly from the mid-1980s, current levels among urban MSM in the United States approximate those of sub-Saharan countries (e.g., 14%-25%) and are extremely high in many population subsegments. Despite years of progress, the AIDS epidemic continues unabated among subsegments of the MSM community.
Relatively little is known of the nutritional requirements of sea urchins, especially at the juvenile stages. One of the costly restrictions on feed formulation for marine fish species is the ...requirement for fish oils to supply the essential n-3 highly unsaturated fatty acids (HUFA). This study investigated the effects of different dietary lipid sources on the fatty acid composition and metabolism of juvenile green sea urchins (
Strongylocentrotus droebachiensis). Kelp (
Laminaria longicruris) served as a reference diet. Experimental diets contained 5% of: corn oil (high in 18:2n-6), linseed oil (high in 18:3n-3), menhaden oil (high in n-3 HUFAs 20:5n-3 and 22:6n-3), or 1:1 mixtures of corn oil and linseed oil, or corn oil and menhaden oil or linseed oil and menhaden oil. Unlike marine fish, the sea urchins exhibited ample ability for elongation and desaturation of shorter chain (18 carbon) polyunsaturated fatty acids (PUFA) to longer chain (20 carbon) n-3 and n-6 HUFA. Thus 18:2n-6 from corn oil in the diet resulted in high levels of 20:4n-6 in the sea urchin and similarly 18:3n-3 in the diet resulted in high levels of 20:5n-3. Even when fed kelp or diets with menhaden oil, the sea urchins did not incorporate high levels of 22:6n-3 into their lipids. In addition to the effects of dietary lipid sources on fatty acid composition of the lipids of total soft tissues of sea urchin, there were great differences in fatty acid composition among different tissues and among lipid classes of these tissues. For example, the test (shell) and associated tissue membranes, which are in constant contact with the seawater, incorporated much higher proportions of 20:4n-6 than the gonad or gut tissues. This may reflect an important role of 20:4n-6 in ion transport and osmoregulation. The sea urchins also synthesized a number of 20 and 22 carbon non-methylene-interrupted dienes (NMID) and the concentration of the major NMID was directly related to the tissue levels of 18:2n-6 and inversely proportional to the dietary and tissue levels of n-3 PUFA and HUFA. The significance of these and other interesting aspects of fatty acid metabolism in sea urchins are discussed.
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