The present study investigates the effects of some quinolone carboxylic acid derivatives on GABAA receptor-mediated excitatory responses in gastrointestinal preparations in vivo and in vitro. In ...stomach-perfused rats, norfloxacin, nalidixic and pipemidic acid dose dependently antagonized acid hypersecretion induced by muscimol. Under the same conditions, the quinolone derivatives failed to modify acid hypersecretion evoked by 2-deoxy-D-glucose. In the isolated guinea-pig ileum, norfloxacin, nalidixic and pipemidic acid antagonized muscimol-elicited contractions in a non-competitive manner. In contrast, these drugs did not influence ileal cholinergic contractions evoked by transmural electrical stimulation or by exogenous acetylcholine. Taken together, these results suggest that the quinolone derivatives tested act as antagonists at both central and peripheral GABAA receptors. In addition, GABAA-mediated gastrointestinal responses might represent a simple and reliable method to assay the GABAA receptor antagonist properties of new quinolone derivatives.
727p index ISBN 9780691149547 cloth, $99.50; ISBN 9780691149554 pbk, $29.95; ISBN 9781400885381 ebook, contact publisher for price This book significantly differs from other volumes of the "Princeton ...Lifesaver Study Guides" series.The work offers chapters on the tools utilized with probability theory; there are two chapters on enumerative combinatorics, one chapter on advanced combinatorics, a section on set theory review, and four appendixes that cover proof techniques and results from real and complex analysis.
413p bibl index ISBN 9783319564326 cloth, $129.00; ISBN 9783319564333 ebook, $99.00 Dynamical Systems in Population Biology focuses on the applications of non-autonomous semiflows to population ...dynamics. The remaining 11 chapters are various applications of the preceding theory to a wide array of models, such as chemostat models, almost periodic competitive systems, and predator-prey models.
408p bibi Index ISBN 9781498777681 cloth, $119.95; ISBN 9781315181592 ebook, $83.97 This is a "rigorous" introduction to real analysis for more advanced undergraduate students of mathematics. The ...removal of advanced material enables the author to discuss the fundamental parts of the subject in more detail and to include more exercises (about ten per section, appearing in increasing order of difficulty).
