The role of individual and sociocultural factors contributing to drowning risk for young adults is complex and poorly understood. This study examined the relationship between behaviour in and around ...waterways and: 1) alcohol consumption; 2) resistance to peer influence; 3) sensation-seeking; 4) perception of risk among people aged 15–24 in Western Australia. A cross-sectional online survey was conducted at three time-points with a convenience sample. Predictor variables included: Alcohol Use Disorder Identification Test Consumption (AUDIT_C); Resistance to Peer Influence; Brief Sensation Seeking scale; Benthin’s Perception of risk. Pearson chi-squared tests determined the association between demographic and predictor variables. Logistic regression explored influence of potential predictor variables on behaviour in and around water. The final sample (n = 730) participants, consisted of females (n = 537, 74.5%), metropolitan dwelling (n = 616, 84.4%), and attended university (n = 410, 56.9%). Significant associations were found for those who swum after drinking alcohol compared with those that had not by age, gender, education. For every 1-unit increase in AUDIT-C participants were 60% more likely to swim after drinking (OR 95% CI 1.60 1.44–1.78). Participants who considered an adverse event serious were 15% less likely to have swum after drinking alcohol (OR 0.85 95% CI 0.73–0.99). The complex relationship between social participation in activities in and around waterways, higher drowning rates, propensity for risk, and the meaning young adults attach to risk locations and practices present unique challenges for drowning prevention research. Findings should be used to improve the awareness and education components of future youth water safety strategies in high-income settings.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A MW 6.3 earthquake struck on April 6, 2009 the Abruzzi region (central Italy) producing vast damage in the L'Aquila town and surroundings. In this paper we present the location and geometry of the ...fault system as obtained by the analysis of main shock and aftershocks recorded by permanent and temporary networks. The distribution of aftershocks, 712 selected events with ML ≥ 2.3 and 20 with ML ≥ 4.0, defines a complex, 40 km long, NW trending extensional structure. The main shock fault segment extends for 15–18 km and dips at 45° to the SW, between 10 and 2 km depth. The extent of aftershocks coincides with the surface trace of the Paganica fault, a poorly known normal fault that, after the event, has been quoted to accommodate the extension of the area. We observe a migration of seismicity to the north on an echelon fault that can rupture in future large earthquakes.
Centaurea amanosensis M. Bona, a new species of Asteraceae from Hatay province of Turkey is described and illustrated. It is morphologically similar to C. cheirolopha (Fenzl) Wagenitz, C. lycopifolia ...Boiss. & Kotschy ex Boiss. & Kotschy, and C. stevenii Bieb. (Section Pseudoseridia), but it differs mainly in life form, general habit, leaves and achene characters. The IUCN conservation status of Critically Endangered (CR) should be applied to C. amanosensis.
Aliment Pharmacol Ther 31, 1104–1111
Summary
Background Intestinal‐type gastric cancer (GC) still ranks among the high‐incidence, highly lethal malignancies. Atrophic gastritis is the cancerization ...field in which GC develops. The current histological reporting formats for gastritis do not include any (atrophy‐based) ranking of GC risk.
Aim To test the gastritis OLGA‐staging (Operative Link for Gastritis Assessment) in prognosticating neoplastic progression.
Methods Ninety‐three Italian patients were followed up for more than 12 years (range: 144–204 months). Clinical examinations, pepsinogen serology, endoscopy and histology (also assessing Helicobacter pylori status) were performed both at enrolment (T1) and at the end of the follow‐up (T2).
Results All invasive or intra‐epithelial gastric neoplasia were consistently associated with high‐risk (III/IV) OLGA stages. There was a significant inverse correlation between the mean pepsinogen ratio and the OLGA stage (test for trend; P < 0.001). OLGA‐staging at T1 predicted both the OLGA stage (Kaplan–Maier log‐rank test, P = 0.001) and the neoplasia at T2 (Kaplan–Maier log‐rank test, P = 0.001).
Conclusions This long‐term follow‐up study provides the first evidence that gastritis OLGA‐staging conveys relevant information on the clinico‐pathological outcome of gastritis and therefore for patient management. According to OLGA‐staging and H. pylori‐status, gastritis patients could be confidently stratified and managed according to their different cancer risks.
Denervation-induced muscle atrophy is a frequent cause of skeletal muscle diseases. However, the role of the most important muscle growth factor, insulin-like growth factor (IGF-1), in this process ...is poorly understood. IGF-1 activity is controlled by six IGF-1 binding proteins (IGFBPs). In skeletal muscle, IGFBP-5 seems to have an important role in atrophic processes. Furthermore, pappalysins (PAPP-A) modulate muscle growth by increasing IGF-1 bioavailability through IGFBP cleavage. We aimed to study the time-dependent changes in the IGF1-IGFBP5-PAPP system and its regulators in gastrocnemius muscle after sciatic denervation. Gastrocnemius atrophy and overexpression of IGF-1 was observed from day 3 post-denervation. The proteolytic factors measured were elevated from day 1 post-denervation onwards. Expression of both IGFBP-5 and pappalysins were increased on days 1 and 3. Subsequently, on days 7 to 14 pappalysins returned to control levels while IGFBP-5 remained elevated. The ratio IGFBP-5/PAPP-A was correlated with the main proteolytic markers. All data suggest that the initial increase of pappalysins could facilitate the IGF-1 action on muscle growth, whereas their subsequent decrease could lead to further muscle wasting.
An extensive study was carried out in coal samples coming from several origins trying to establish a relationship between nine coal properties (moisture (%), ash (%), volatile matter (%), fixed ...carbon (%), heating value (kcal/kg), carbon (%), hydrogen (%), nitrogen (%) and sulphur (%)) and the corresponding near-infrared spectral data. This research was developed by applying both quantitative (partial least squares regression, PLS) and qualitative multivariate analysis techniques (hierarchical cluster analysis, HCA; linear discriminant analysis, LDA), to determine a methodology able to estimate property values for a new coal sample. For that, it was necessary to define homogeneous clusters, whose calibration equations could be obtained with accuracy and precision levels comparable to those provided by commercial online analysers and, study the discrimination level between these groups of samples attending only to the instrumental variables. These two steps were performed in three different situations depending on the variables used for the pattern recognition: property values, spectral data (principal component analysis, PCA) or a combination of both. The results indicated that it was the last situation what offered the best results in both two steps previously described, with the added benefit of outlier detection and removal.
We update the constraints on new-physics contributions to ΔF = 2 processes from the generalized unitarity triangle analysis, including the most recent experimental developments. Based on these ...constraints, we derive upper bounds on the coefficients of the most general ΔF = 2 effective Hamiltonian. These upper bounds can be translated into lower bounds on the scale of new physics that contributes to these low-energy effective interactions. We point out that, due to the enhancement in the renormalization group evolution and in the matrix elements, the coefficients of non-standard operators are much more constrained than the coefficient of the operator present in the Standard Model. Therefore, the scale of new physics in models that generate new ΔF = 2 operators, such as next-to-minimal flavour violation, has to be much higher than the scale of minimal flavour violation, and it most probably lies beyond the reach of direct searches at the LHC.
Permeability is an important parameter of oceanic crust: it controls hydrothermal circulation and influences the exchange of heat and chemicals between seawater and the crust. Using the most complete ...section of intact, in situ normal oceanic crust, this paper presents the first permeability measurements of samples from Integrated Ocean Drilling Program (IODP) Hole 1256D in a relatively undisturbed section through lavas, dikes, and into gabbros. At in situ pressures, saturated gabbro from Hole 1256D is about half as permeable as basalt (2.4 × 10−20 m2 and 4.0 × 10−20 m2, respectively). Although fresh basalt samples have higher permeabilities, the basalts at Hole 1256D contain saponite, an alteration mineral which drastically reduces permeability. These measurements represent an opportunity for comparison to models that predict permeability at IODP Hole 1256D. Similar to model predictions, sample permeability generally decreases with depth. However, even after applying the scaling rule, models predict higher permeabilities than exhibited by the samples, suggesting large‐scale cracks still control permeability in the 15 My old crust at Hole 1256D.
Key Points
This paper presents the first direct permeability measurements of samples from IODP Hole 1256D
Saturated basalt and gabbro samples have permeability ∼10−20 m2 at in situ pressures
Permeability decreases with depth and gabbro permeability is more pressure‐dependent than basalt
The status of the unitary triangle beyond the standard model including the most recent results on Deltams on dilepton asymmetries and on width differences is presented. Even allowing for general new ...physics loop contributions the unitarity triangle must be very close to the standard model result. With the new measurements from the Fermilab Tevatron, we obtain for the first time a significant constraint on new physics in the Bs sector. We present the allowed ranges of new physics contributions to DeltaF=2 processes and of the time-dependent CP asymmetry in Bs-->J/psivarphi decays.
The permeability structure of oceanic crust controls both the spatial and temporal extent of hydrothermal circulation, but the detailed geometry of fractures in seafloor rocks is not well known. We ...apply an equivalent channel model to veins, joints, faults, and breccias preserved in recovered cores from ODP‐IODP Hole 1256D to calculate paleo‐permeability. In the ~250‐m transition between dikes and lavas, paleo‐permeability is 10−13~10−14 m2 with narrow zones of >10−9 m2 that presumably act as conduits for the largest volume of fluids. Most of these high‐permeability zones are oriented vertically as a result of diking events into a significant thickness of lavas outside of the neovolcanic zone. After an increase in permeability due to off‐axis diking events, fluid temperatures drop, pathways are sealed, and the permeability of the upper oceanic crust drops significantly.
Key Points
Vertical fractures dominate the permeability structure of the transition between dikes and lavas at IODP Hole 1256D
Diking opens new vertical pathways for hydrothermal circulation outside the neovolcanic zone
Crustal permeability is reduced by 1–2 orders of magnitude by vein filling
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