Abstract
As current therapies for cardiovascular disease (CVD), predominantly based on lipid lowering, still face an unacceptable residual risk, novel treatment strategies are being explored. Besides ...lipids, inflammatory processes play a major role in the pathogenesis of atherosclerosis, the underlying cause of the majority of CVD. The first clinical trials targeting the interleukin-1β-inflammasome axis have shown that targeting this pathway is successful in reducing cardiovascular events but did not decrease overall CVD mortality. Hence, novel and improved immunotherapeutics to treat CVD are being awaited.
A prolonged preclinical phase of more than two decades before the onset of dementia suggested that initial brain changes of Alzheimer’s disease (AD) and the symptoms of advanced AD may represent a ...unique continuum. Given the very limited therapeutic value of drugs currently used in the treatment of AD and dementia, preventing or postponing the onset of AD and delaying or slowing its progression are becoming mandatory. Among possible reversible risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors were associated with the development of dementia and late-life cognitive disorders, opening new avenues for the prevention of these diseases. Among diet-associated factors, coffee is regularly consumed by millions of people around the world and owing to its caffeine content, it is the best known psychoactive stimulant resulting in heightened alertness and arousal and improvement of cognitive performance. Besides its short-term effect, some case-control and cross-sectional and longitudinal population-based studies evaluated the long-term effects on brain function and provided some evidence that coffee, tea, and caffeine consumption or higher plasma caffeine levels may be protective against cognitive impairment/decline and dementia. In particular, several cross-sectional and longitudinal population-based studies suggested a protective effect of coffee, tea, and caffeine use against late-life cognitive impairment/decline, although the association was not found in all cognitive domains investigated and there was a lack of a distinct dose-response association, with a stronger effect among women than men. The findings on the association of coffee, tea, and caffeine consumption or plasma caffeine levels with incident mild cognitive impairment and its progression to dementia were too limited to draw any conclusion. Furthermore, for dementia and AD prevention, some studies with baseline examination in midlife pointed to a lack of association, although other case-control and longitudinal population-based studies with briefer follow-up periods supported favourable effects of coffee, tea, and caffeine consumption against AD. Larger studies with longer follow-up periods should be encouraged, addressing other potential bias and confounding sources, so hopefully opening new ways for diet-related prevention of dementia and AD.
Introduction
Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in ...young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS).
Design
NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14.
Setting/participants
98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD.
Intervention
The intervention strategy was the assignment of a LGIMD or a control diet.
Outcome measures
The main outcome measure was NAFLD score, defined by LUS.
Results
After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (-4.14, 95% CI -6.78,-1.49) was observed, and became more evident at the sixth month (-4.43, 95%CI -7.15, -1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed.
Conclusions
LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.
The corona virus disease 2019 (COVID-19) pandemic forced most of the Italian population into lockdown from 11 March to 18 May 2020. A nationwide survey of Italian Clinical Nutrition and Dietetic ...Services (Obesity Centers or OCs) was carried out to assess the impact of lockdown restrictions on the physical and mental wellbeing of patients with obesity (PWO) who had follow-up appointments postponed due to lockdown restrictions and to compare determinants of weight gain before and after the pandemic.
We designed a structured 77-item questionnaire covering employment status, diet, physical activity and psychological aspects, that was disseminated through follow-up calls and online between 2 May and 25 June 2020. Data were analyzed by multiple correspondence analysis (MCA) and multiple linear regression.
A total of 1,232 PWO from 26 OCs completed the questionnaires (72% female, mean age 50.2 ± 14.2 years; mean BMI 34.7 ± 7.6 kg/m
; 41% obesity class II to III). During the lockdown, 48.8% gained, 27.1% lost, while the remainder (24.1%) maintained their weight. The mean weight change was +2.3 ± 4.8 kg (in weight gainers: +4.0 ± 2.4 kg; +4.2% ± 5.4%). Approximately 37% of participants experienced increased emotional difficulties, mostly fear and dissatisfaction. Sixty-one percent reduced their physical activity (PA) and 55% experienced a change in sleep quality/quantity. The lack of online contact (37.5%) with the OC during lockdown strongly correlated with weight gain (p < 0.001). Using MCA, two main clusters were identified: those with unchanged or even improved lifestyles during lockdown (Cluster 1) and those with worse lifestyles during the same time (Cluster 2). The latter includes unemployed people experiencing depression, boredom, dissatisfaction and increased food contemplation and weight gain. Within Cluster 2, homemakers reported gaining weight and experiencing anger due to home confinement.
Among Italian PWO, work status, emotional dysregulation, and lack of online communication with OCs were determinants of weight gain during the lockdown period.
A promising solution in the field of passive two-phase heat transfer devices is represented by Pulsating Heat Pipes (PHPs). They are undoubtedly appealing due to the high heat transfer capability, ...efficient thermal control, adaptability and low cost. In the last years they are raising concern for space applications that are characterised by extreme environmental conditions, strictly constrains in terms of compactness, reliability and the need to dissipate efficiently heat in microgravity conditions. In this study, the thermal performance of oscillating heat pipes that consists of extra-thin metallic pipes are investigated: the adoption of metallic pipes with an inner diameter less than 0.4 mm permits to couple flexibility and compactness with high heat transfer performance. HFC-134a is used as working fluid. Many authors have investigated the pulsating behaviour of this type of heat transfer devices only considering the average temperature of the evaporator and condenser. In this work, to deeply investigate the oscillating behaviour of the proposed PHP, it is adopted an approach based on the study of the local temperature distributions on the wall of the PHP, acquired with a high-speed and high-resolution infrared camera. The local analysis of the temperature trends is of fundamental importance in the understanding of the complex phenomena that govern the pulsating field.
Nowadays global warming has increased consciousness of the dangers of energy wastefulness: in the last 50 years the temperature of the Earth's surface rose by approximately 1 °C. The building sector ...is responsible for a very high percentage of world carbon emissions and with the increasing of the request for comfort, heating, ventilation and air conditioning, buildings energy consumption is rapidly growing. Consequently, it appears fundamental the role played by the improvement of buildings energy performance within global policies of emissions reduction. In this context an increasing attention is given to the energy waste reduction in tertiary sector: bars, offices, restaurants, meetings, shops, school buildings, gyms and in general in the buildings in which the minimization of the energy dissipation is requested. The present study is part of the NANOFANCOIL project (POR-FESR 2014-2020): one of the objectives was the design and implementation of a modulating test plant to assess the performance of innovative cross-flow heat recovery units for air conditioning system. This experimental setup was mainly composed by two climatic chambers that enabled to simulate the environmental conditions of interest. The temperature could vary from -20°C to 0°C and from 10°C to 30°C for the cold and the hot chamber, respectively (i.e. the outdoor and the indoor environment). Moreover, the climatic chamber that simulates the indoor environment could be controlled also in terms of humidity thanks to a steam humidifier that guaranteed 5 kg/h of vapour. Preliminary results about the heat transfer behaviour of a cross-flow heat recovery unit (air-to-air) for controlled mechanical ventilation systems that employs mini-channels in order to increase performance and reduce size and costs are presented here.
We aimed to investigate the association of the clinical variables of the metabolic syndrome (MS) and psychological parameters on health-related quality of life (HRQL) in obesity. In particular, our ...aim was to investigate the relative impact of physical symptoms, somatic diseases and psychological distress on both the physical and the mental domains of HRQL.
Cross-sectional study.
A cohort of 1822 obese outpatients seeking treatment in medical centers.
HRQL was measured by the standardized summary scores for physical (PCS) and mental (MCS) components of the Short Form 36 Health Survey (SF-36). Patients were grouped according to tertiles of PCS and MCS. Metabolic and psychological profiles of PCS and MCS tertiles were compared by discriminant analysis.
The profile of metabolic and psychological variables was tertile-specific in 62.4 and 68.3% of patients in the lowest and highest tertiles of PCS, respectively, while concordance was low in the mid-tertile (32.8%). Concordance was very high in the lowest (74.4%) and in the highest (75.5%) tertiles of MCS, and was fair in the mid-tertile (53.2%). The main correlates of PCS were obesity-specific and general psychological well-being, BMI, body uneasiness, binge eating, gender and psychiatric distress. Only hypertension and hyperglycemia qualified as correlates among the components of MS. The components of MS did not define MCS.
Psychological well-being is the most important correlate of HRQL in obesity, both in the physical and in the mental domains, whereas the features of MS correlate only to some extent with the physical domain of HRQL.
Introduction The prevalence of Anxiety Disorders (ADs) among the elderly (65 plus) varies across studies, because of differences in diagnostic criteria's definition and the heterogeneity of clinical ...presentation. Furthermore the comorbidity of anxiety with affective disorders is controversial. Objectives Estimate the prevalence of ADs in 65 years plus subjects in a random sampling of the general population and provide current estimates of comorbidity with affective disorders. Methods The sample was collected in the Great Age study, a population-based study conducted in a random sampling of the elderly residents in Castellana, South-East Italy. It includes 719 participants (56,33% males). Through the SCID-IVTR interview performed by a psychiatrist, ADs diagnosis and classification in subtypes (phobia, generalized anxiety disorder, OCD, panic disorder, post-traumatic stress disorder, adjustment disorder and AD nos) were assessed. Results The 30,25% of females and 15,30% of males were positive for any DSM-VI disorder. The ADs prevalence was 10,43% (14,97% of women; 6,91% of men; mean age at interview 72 years). Rates prevalence in 65-74 age stratum was 11,78%; 8,1% in 75-84 and 10,26% in the oldest age. The ADs were classified as phobia (1,49%), GAD (2,22%), OCD (0,28%), panic disorder (0,7%), PTSD (0,55%), adjustment disorder (1,67%) and AD nos (3,75%). 21,33% of the ADs had apparently new-onset (Late OnsetADs). Affective disorders occur in 25,33% of ADs. Conclusions The prevalence rates of ADs in late life tend to decline, but remain the most common psychiatric disorders, especially in women. Anxiety co-occurs with affective disorders in similar rate to Late OnsetADs. Founding: PRIN2009E4RM4Z
Introduction Depression is a common disorder in late-life. Structured clinical interviews may be less efficient compared to self-administered questionnaires, but provide more accurate findings in ...terms of diagnosis. No population-based studies with both these depression assessment instruments have been ever performed. Objectives To estimate the GDS-30 accuracy for depression assessment against the gold standard Semi-structured Clinical Diagnostic Interview for DSM-IV-TR Axis I Disorders (SCID) in subjects 65+ years in a random sampling of the general population. Methods The sample was collected in a population-based study (GreatAGE) conducted among elderly residents in Castellana, Southeast Italy. It includes 597 participants (57.62% males, mean age 73 years). Depression was assessed through the GDS-30 and the SCID, both double-blinded administered respectively by a trained neuropsychologist and psychiatrist. The GDS-30 screening performances were analyzed using ROC curves. Results According to the gold standard SCID, the rate of depressive disorder was 10.22% (15.81% of women; 6.1% of men) while with GDS-30 instrument 12.06% of the residents met the depression cutoff. Only 36.1% of GDS cases were true positive. At the optimal cutoff score (> 5), GDS had 62% sensitivity and 81% specificity. Using a more conservative cutoff (> 9), the GDS-30 specificity reached 91% while sensitivity dropped to 43%. Conclusions These preliminary results from the first population-based study that compares GDS-30 and SCID showed that the GDS-30 identified adequate levels of screening accuracy (AUC 0.76) compatible with scores established in community settings. Funding PRIN2009E4RM4Z.
Soil bacteria (rhizobia) of the genus Bradyrhizobium form symbiotic relationships with peanut root cells and fix atmospheric nitrogen by converting it to nitrogenous compounds. Inoculation of peanut ...with rhizobia can enhance the plant’s ability to fix nitrogen from the air and thereby reduce the requirement for nitrogen fertiliser. We evaluated three Bradyrhizobium sp. strains for effect on root nodulation and on pod yield of peanut in Argentina soils, using laboratory and field experiments. Of these, strain C‐145 was the most effective in laboratory studies. In‐furrow inoculation with this strain produced increased nodule number, relative to seed inoculation. However, pod yield was not increased significantly by either type of inoculation. In view of the inconsistent response of peanut to inoculation, we examined the effect of indigenous strains of bradyrhizobia. The high degree of nodulation and nitrogen fixation produced by indigenous rhizobia were sufficient for maximal yield under the field and inoculation conditions used in this study. The data are important for future investigation of alternative inoculant strains and conditions for improving peanut production.
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